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Washington vs UCLA Predictions, Picks, Odds and Trends for November 22 2025

By: Josh Collacchi Published 11/22/2025, 06:04 AM ET
UCLA QB Nico Iamaleava

Washington vs UCLA prediction with line movement history, matchup notes, side and total selections, and a projected final score. For more college football breakdowns, take a look at our college football picks by game.

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Quick Picks and Prediction: Washington vs UCLA

  • Side: Washington Huskies -10.5
  • Total: Over 51.5
  • Projected Final Score: Washington Huskies 35, UCLA Bruins 24
  • Confidence (0–3): Side 1.5 / Total 1.5

Odds and Line Movement: WASH vs UCLA

FanDuel has installed Washington as a double digit road favorite, with the total settling in the low 50s after multiple adjustments on both the side and the number.

Line Movement - Spread

Hottest Cappers L30 Days
# Handicapper Profit
1 Earle Sports Bets Earle Sports Bets +2,298.00
2 Ross Benjamin Ross Benjamin +1,840.00
3 Rob Vincilleti Rob Vincilleti +1,757.00
4 David Hess David Hess +1,745.00
5 Dan Kaiser Dan Kaiser +987.00
Date Time Washington UCLA Public ($, #)
11/18 06:38:40am -10½ (-110) +10½ (-110)
11/17 05:05:36am -10½ (-110) +10½ (-110)
11/16 07:39:21am -10½ (-122) +10½ (+100)
11/16 07:02:41am -9½ (-122) +9½ (+100)

Line Movement - Total

Date Time Over Under Public ($, #)
11/18 07:13:17am 51½ o(-110) 51½ u(-110)
11/18 06:38:40am 51½ o(-110) 51½ u(-110)
11/18 05:05:36am 52 o(-110) 52 u(-110)
11/16 05:21:09pm 52½ o(-110) 52½ u(-110)
11/16 07:02:41am 51½ o(-105) 51½ u(-115)

Key Matchups and Handicap: Washington vs UCLA

Washington earned a 31-19 home win over the Bruins last season, and six of the last seven meetings between these programs have gone over the total. The Huskies have alternated wins and losses over their last five games, and they have failed to cover the spread in each of their last three road contests, creating some uncertainty when laying a sizeable number away from home.

On the UCLA side, starting quarterback Nico Iamaleava is questionable after missing last week’s game against Ohio State. He suffered a concussion the previous week against Nebraska and was still dealing with lingering symptoms. The Bruins bring a three game losing streak into this matchup, and all three of those defeats have gone over the total, pointing to defensive issues and game scripts that have required chasing from behind.

Washington has been a difficult team to trust this season, especially against the number on the road, but the combination of series history, recent offensive production, and quarterback concerns for UCLA nudges the handicap toward the Huskies. If Iamaleava is less than full strength or limited, the Bruins may again need to lean on a defense that has not been able to keep games under control during their current skid.

  • Washington beat UCLA 31-19 at home last season.
  • Six of the last seven meetings between Washington and UCLA have gone over the total.
  • Washington has alternated wins and losses over its last five games.
  • The Huskies have failed to cover the spread in their last three road games.
  • UCLA has lost three straight games, and all three have gone over the total.

Key Injuries and Notes: Washington vs UCLA

  • UCLA quarterback Nico Iamaleava is questionable after missing the Ohio State game due to concussion symptoms suffered against Nebraska.

ATS and Total Picks: WASH vs UCLA

Series history and the Bruins recent form make it difficult to step in front of Washington despite its inconsistent against the spread record. With overs dominating both in the head to head series and in UCLA’s latest results, the total also leans toward a higher scoring outcome.

Spread Pick — Huskies vs Bruins

  • Pick: Washington Huskies -10.5
  • Why: Washington has controlled recent matchups, and UCLA comes in on a three game slide with uncertainty at quarterback, creating an opportunity for the Huskies to separate over four quarters.

Total Pick — Washington vs UCLA

  • Pick: Over 51.5
  • Why: Six of the last seven meetings have gone over the total, and all three recent UCLA losses have landed over as well, suggesting another matchup with enough scoring to clear the low 50s.

Final Score Prediction: Washington vs UCLA

Washington Huskies 35, UCLA Bruins 24

How to Bet: Huskies vs Bruins

Bettors backing Washington should look for spreads of -10.5 or better, while UCLA supporters will want as many points as possible in the underdog role, ideally above the key number of ten. For the total, Over players should aim to secure 51.5 before any move higher, and Under players would prefer a number closer to 53.

Track how the market responds to updates on Nico Iamaleava’s status and any late action on the side or total so you can lock in the best available number before kickoff. If you are looking to find some further value, you can take advantage of sportsbook promos and get a welcome offer that may help you get a bankroll boost.

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