West Virginia Mountaineers vs. Kansas Jayhawks Prediction and Picks – September 20, 2025

By: David Delano Published 09/18/2025, 06:50 PM ET
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The Kansas Jayhawks (2-1) are hosting the West Virginia Mountaineers (2-1) on Saturday in a Big 12 battle. Last season, the Jayhawks finished 9-4, while West Virginia went 7-6 and reached a bowl game. Kansas has won two of the last three in this series, and this meeting could play a key role in shaping the early Big 12 standings.

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Mountaineers looking to grind out another upset

West Virginia enters this matchup off an emotional 31-24 overtime win against Pitt, improving to 2-1 on the season. The Mountaineers lean heavily on their ground game, averaging 213.0 rushing yards per contest, which ranks in the national top 35. Running back Tye Edwards has led the way with 141 yards and three touchdowns, while Jahiem White brings change-of-pace speed.

Quarterback Nicco Marchiol has been steady under center, throwing for 594 yards and two touchdowns with a 66 percent completion rate. His connection with receiver Cam Vaughn, who already has 204 yards, gives the passing game some needed balance. WVU also plays opportunistic defense, led by safety Darrian Lewis, who has contributed 21 tackles and two interceptions.

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Still, turnovers have plagued the Mountaineers (seven through three games), and facing a Kansas team that thrives on capitalizing on mistakes, limiting giveaways will be the biggest factor if they hope to pull off a road upset. .

Jayhawks aiming to control tempo at home

Kansas enters at 2-1 following a high-scoring road loss to Missouri, but its offense has been excellent through three weeks. Veteran quarterback Jalon Daniels is off to a standout start, throwing for 679 yards and nine touchdowns with just two picks while completing 72 percent of passes. Daniels’ accuracy and decision-making have elevated the Jayhawks into the top 50 nationally in scoring at 36.0 points per game.

Supporting him in the backfield is Daniel Hishaw Jr., who has rushed for 169 yards, and freshman receiver Emmanuel Henderson Jr., who leads the team with 183 receiving yards. This balance has kept defenses off guard.

On defense, Kansas allows a manageable 318 yards per game, with linebacker Trey Lathan racking up 25 tackles early in the year. The group has shown strengths at limiting rushing efficiency, a key matchup factor with West Virginia relying so heavily on its ground attack. At home, the Jayhawks will aim to dictate tempo and force WVU away from its comfort zone.

West Virginia vs Kansas Picks

Spread Pick for West Virginia vs. Kansas

  • ATS Prediction: Kansas -12.5 (4 units)

Kansas has the more balanced and explosive offense in this matchup, driven by Jalon Daniels’ efficient quarterback play. West Virginia’s ground game can keep them competitive, but their turnover issues and lack of passing explosiveness hurt their upset chances. The Jayhawks should find enough offensive rhythm to cover comfortably at home.

Over/Under Pick for West Virginia vs. Syracuse

  • Total Prediction: Under 55.5 (4 units)

West Virginia will try to slow the game down by leaning on the run game, while Kansas’ defense is strong against the ground attack. Even though the Jayhawks can score quickly, the Mountaineers’ style will shorten the game and reduce possessions. With WVU averaging under 29 points per game and Kansas capable of controlling the pace, the under looks like the best play.

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