Western Kentucky vs LSU, Picks and Prediction for Saturday, November 22, 2025
The Western Kentucky Hilltoppers (8-2, 6-1, CUSA) step away from conference play on Saturday for a game on the road in Baton Rouge against the LSU Tigers (6-4, 3-4 SEC). Western Kentucky defeated Middle Tennessee 42-26 last Saturday. Western Kentucky has won three straight and six of the last seven. The Hilltoppers are second in Conference USA, a half-game behind Jacksonville State with one conference game remaining. LSU defeated Arkansas 23-22 last time out, snapping a three-game losing streak, but it is well off the pace in the SEC. Make sure to read this in-depth Western Kentucky Hilltoppers vs LSU Tigers prediction. Buckle up! Dive into our top NCAAF picks for Western Kentucky Hilltoppers at LSU Tigers prediction and dominate your wagers.
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Western Kentucky is scoring well and playing well on defense
The Western Kentucky Hilltoppers score an average of 31.3 points (46th) per game, and allow an average of 23.1 points (51st) per game. Western Kentucky is 11th in passing yards and 93rd in rushing yards per game. The Hilltoppers average 432.9 yards of total offense, which is 30th. Western Kentucky's defense is 75th in passing yards and 105th in rushing yards allowed per game. The Hilltoppers allow an average of 398.8 yards per game, which is 94th.
Western Kentucky starting quarterback Maverick McIvor is listed as questionable and missed the Hilltoppers' game this past Saturday. McIvor has 1,863 yards passing with 12 touchdowns and 5 interceptions. Backup quarterback Rodney Tisdale Jr has thrown for 1,059 yards with nine touchdowns and three interceptions. Last Saturday versus Middle Tennessee, Tisdale threw for 371 yards, with 3 TDs, and 1 INT. Marvin Parrish is the leading rusher for Western Kentucky with 427 yards, while La’Vell Wright has 327 yards and eight touchdowns. Matthew Henry leads all receivers with 703 yards and six touchdown receptions. Linebacker Jaylen Wester is the leading tackler with 64. Western Kentucky has made 12 quarterback sacks and intercepted seven passes.
Injuries: Western Kentucky’s QB Maverick McIvor is questionable
LSU needs more scoring, but its defense is solid
The LSU Tigers score an average of 23.6 points (100th) per game and allow an average of 19.3 points (19th) per game. LSU is 62nd in passing yards and 124th in rushing yards per game. The Tigers average 346.6 yards of total offense per game, which is 101st. The LSU defense is 40th in passing yards and 42nd in rushing yards allowed per game. The Tigers’ defense allows an average of 329.1 yards per game, which is 35th.
| # | Handicapper | Profit |
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| 1 |  Earle Sports Bets | +1,154.00 |
| 2 |  David Hess | +808.00 |
| 3 |  Stephen Nover | +644.00 |
| 4 |  Dan Kaiser | +547.00 |
| 5 |  Rob Vincilleti | +500.00 |
LSU starting quarterback Garrett Nussmeier missed the Tigers’ one-point victory over Arkansas last week and, as of early this week, was listed as questionable (no doubtful), and his status remains unknown. Nussmeier has 1,927 yards passing with 12 touchdowns and 5 interceptions. Backup Michael Van Buren Jr, who played last week versus Arkansas, has 445 yards passing with three touchdown passes. Running back Caden Durham leads all rushers with 447 yards and three touchdowns, while wide receiver Barion Brown has a team-high 449 yards and one touchdown reception. Safety A.J. Haulcy is the leading tackler with 73. The LSU defense has made 22 quarterback sacks and intercepted 12 passes.
Key Injuries for LSU:
LSU will play without RB JT Lindsey, while three others are questionable, and QB Garrett Nussmeier is doubtful.
| # | Handicapper | Profit |
|---|---|---|
| 1 | Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 | Rob Vincilleti | +1,757.00 |
| 4 | David Hess | +1,745.00 |
| 5 | Dan Kaiser | +987.00 |
Western Kentucky Hilltoppers vs. LSU Tigers Pick
Spread Pick for Western Kentucky vs. LSU
- Western Kentucky Hilltoppers +22.5 ( units)
Both starting quarterbacks missed their team's most recent game, and both are listed as questionable. Western Kentucky received a very strong game from its backup QB last time out as Rodney Tisdale Jr threw for 371 yards with three touchdowns and one interception. Western Kentucky has a big hill to climb to win this game outright, but the Hilltoppers, with their offensive production and solid defense, will play well enough to cover the number. Western Kentucky has covered the spread in six of its last seven. LSU will have a drop off if starting quarterback Garrett Nussmeier is unable to play, as last week, when they played without their starting QB, the Tigers won by just one point over Arkansas. LSU has covered the spread in just one of its last seven games and continues to play under an interim coach after Brian Kelly was fired.
Over/Under Pick for Western Kentucky vs. LSU
- Under 49.5 ( units)
The defenses are both strong in this matchup, and both teams may play without their starting quarterbacks. Although the backup quarterbacks are adequate, they do not have the same experience as the starters and could commit more mistakes, throw fewer completions, and overall cause more drives to stall. The total has finished under in five of Western Kentucky's last seven games and in 14 of LSU's last 20 games. LSU is 19th in points allowed at 19.3 points per game, and Western Kentucky is 51st at 23.1 points per game.
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