Los Angeles Angels vs. Milwaukee Brewers, Picks and Prediction, Tuesday, September 16, 2025
Use Code WWWC Los Angeles (69-81) will be going for the series lead when they visit American Family Field on Tuesday night to face Milwaukee (91-59) in the first game of their three-game interleague series at 7:40 PM. ET. Read on to find out which team picks up the win in this Angels vs. Brewers prediction. Don’t go down on strikes! Get our top MLB Predictions and increase your bankroll!
Caden Dana, 0-1, 6.32 ERA, will get the start for the Angels. The Brewers will counter with Freddy Peralta, 16-6, 2.69 ERA.
Los Angeles is 6-4 in its last 10 games against Milwaukee.
Los Angeles Trying To Snap Four-Game Losing Streak
The Angels followed up their series win over Minnesota with a four-game sweep at the hands of the Mariners. They will try to put an end to their losing streak and take the series lead with a win on Tuesday.
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Los Angeles averages 4.26 runs per game, which is 23rd in the league. Their .228 batting average is 29th in the league. Their .302 on base percentage is 28th, while their .399 slugging percentage is 15th.
Nolan Schanuel leads Los Angeles with a .266 batting average. Jo Adell leads the team with 36 home runs, while Taylor Ward leads the team with 98 RBI.
Los Angeles is giving up 5.13 runs per game, which is 28th in the league. Opponents have a .260 batting average against the Angels, which is 27th in the league. Their 4.83 ERA is 28th, while their 1.44 WHIP is 29th.
In his last start, Dana gave up five hits and five runs in 4.2 innings, leading to a 12-3 loss to Minnesota.
Milwaukee Trying To Bounce Back From Loss
The Brewers had their two-game winning streak snapped by the Cardinals in the last game of their series, preventing them from getting the sweep. They lead the NL Central, with a 5.5-game edge over the Cubs, and will try to increase their division lead with a win on Tuesday.
Milwaukee averages 5.08 runs per game, which is third in the league. Their .260 batting average is third in the league. Their .333 on base percentage is second, while their .408 slugging percentage is 12th.
Sal Frelick leads Milwaukee with a .295 batting average, while Christian Yellich leads the team with 28 home runs and 96 RBI.
Milwaukee is giving up 3.93 runs per game, which is third in the league. Opponents have a .231 batting average against the Brewers, which is third in the league. Their 3.63 ERA is second, while their 1.24 WHIP is seventh.
In his last start, Peralta gave up six hits and five runs in five innings, leading to a 6-3 loss to Texas. He is 1-0 with a 6.75 ERA in two games against Los Angeles.
Los Angeles Angels vs. Milwaukee Brewers Pick
Run Line Pick for Angels vs. Brewers
- Milwaukee Brewers -1.5 (4 Units)
The Brewers have won two of their last three games, while the Angels have lost four straight games. Milwaukee has the edge here because they’ve done a great job against right-handers, and they’re going up against Dana, who struggled in recent starts, giving up seven runs in his last two starts. With Los Angeles’ bullpen also struggling, they will have a hard time slowing down the Brewers.
Los Angeles won’t be as successful offensively because they’ve struggled against right-handers, and they’re going up against Peralta, who gave up only one run in his last four home starts. Take Milwaukee on the run line.
Over/Under Pick for Angels vs. Brewers
- Under (4 Units)
The Angels average 4.26 runs per game and averaged two runs per game in their last three games. They’re batting .227 against right-handers, and they’re facing a starter who hasn’t given up a run in three straight home starts. The Brewers average 5.08 runs per game and 4.67 runs per game at home. They’re batting .257 against right-handers, and they’re facing a starter who gave up seven runs in two starts. Don’t expect these teams to score enough runs to push the score over the total. The Angels and Brewers played under the total in three of their last four meetings.
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