Los Angeles Dodgers vs. San Francisco Giants, Picks and Prediction, Friday, September 12, 2025
Use Code WWWC Los Angeles (82-64) will be going for the series lead when they visit Oracle Park on Friday night to face San Francisco (74-72) in the first game of their three-game weekend series at 10:15 PM. ET. Read on to find out which team picks up the win in this Dodgers vs. Giants prediction. Don’t go down on strikes! Get our top MLB Predictions and increase your bankroll!
Yoshinobu Yamamoto, 11-8, 2.72 ERA, will get the start for the Dodgers. The Giants will counter with Justin Verlander, 3-10, 4.09 ERA.
Los Angeles is 7-3 in its last 10 games against San Francisco.
Los Angeles Going For Fifth Consecutive Win
The Dodgers bounced back from their five-game losing streak with four straight wins. They are on top of the NL West standings, three games ahead of San Diego and eight games ahead of San Francisco. They will try to pick up their fifth straight win and increase their division lead with a win on Friday.
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Los Angeles averages 5.05 runs per game, which is second in the league. Their .252 batting average is seventh in the league. Their .328 on base percentage is sixth, while their .437 slugging percentage is second.
Freddie Freeman leads Los Angeles with a .292 batting average, while Shohei Ohtani leads the team with 48 home runs and 92 RBI.
Los Angeles is giving up 4.29 runs per game, which is 15th in the league. Opponents have a .237 batting average against the Dodgers, which is eighth in the league. Their 4.03 ERA is 18th, while their 1.27 WHIP is 15th.
In his last start, Yamamoto gave up one hit and one run in 8.2 innings, leading to a 4-3 loss to Baltimore. He is 0-1 with a 4.67 ERA in three games against San Francisco.
San Francisco Trying To Bounce Back From Loss
The Giants had their two-game winning streak snapped by the Diamondbacks in their last game, which prevented them from sweeping the series. They will try to bounce back from the loss and pick up their third win in their last four games when they play on Friday.
San Francisco averages 4.36 runs per game, which is 15th in the league. Their .239 batting average is 24th in the league. Their .314 on base percentage is 19th, as is their .392 slugging percentage.
Jung Hoo Lee leads San Francisco with a .269 batting average, while Willy Adames leads the team with 28 home runs and 81 RBI.
San Francisco is giving up 4.14 runs per game, which is 10th in the league. Opponents have a .247 batting average against the Giants, which is 20th in the league. Their 3.76 ERA is sixth, while their 1.29 WHIP is 16th.
In his last start, Verlander gave up three hits and no runs in six innings, leading to a 3-2 loss to St. Louis. He is 3-1 with a 3.38 ERA in four games against the Dodgers.
Los Angeles Dodgers vs. San Francisco Giants Pick
Money Line Pick for Los Angeles Dodgers vs. San Francisco Giants
- San Francisco Giants ML (4 Units)
The Giants have won eight of their last 10 home games, while the Dodgers have lost seven of their last 10 road games. San Francisco has the edge here because they’ve had a lot of success batting against right-handers, and they’re going up against Yamamoto, who struggled in three starts against them, giving up nine runs. With Los Angeles’ bullpen also struggling on the road, they will have a hard time slowing down the Giants.
Los Angeles won't be as successful offensively because they didn’t hit the ball well in recent road games, and they’re going up against Verlander, who was dominant in recent starts, giving up only two runs in his last three starts. He didn’t give up a run in two of his last three home starts, so expect him to keep Los Angeles’ offense in check. Take San Francisco on the money line.
Over/Under Pick for Los Angeles Dodgers vs. San Francisco Giants
- Under (4 Units)
The Dodgers played under the total in four of their last six games, while the Giants played under the total in three of their last five games. Los Angeles averages 5.05 runs per game and 4.49 runs per game on the road. They’re batting .251 against right-handers, and they’re facing a starter who gave up two runs in his last three home starts. The Giants average 4.36 runs per game and 4.07 runs per game at home. They’re batting .248 against right-handers, and they’re facing a starter who gave up four runs in his last three starts. Don’t expect these teams to score enough runs to push the score over the total. The Dodgers and Giants played under the total in their last two meetings.
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