Arizona Diamondbacks vs. San Diego Padres Picks and Prediction for Sunday, September 28, 2025
Use Code WWWC It’s the conclusion of a three-game series between NL West rivals on the diamond in southern California as the Arizona Diamondbacks travel to face the San Diego Padres in the final game of a three-game set Sunday afternoon and we have you covered with our Diamondbacks vs. Padres prediction. In the opening game of the series Friday night, it was the Padres picking up a 7-4 win to draw first blood. Will Arizona head into the offseason with a win or can San Diego take the series by prevailing here? This article was published prior to the conclusion of the middle game of the series at Petco Park Saturday night. Read more about this Diamondbacks vs. Padres prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Arizona Looking to Close Season With Victory
Arizona suffered a third straight loss as they were dropped in the opening game of this series on Friday night. The Diamondbacks entered Saturday 80-80 on the year and stood fourth in the NL West, 11 games behind the Dodgers for the top spot. They were eliminated from playoff contention for the final wild card spot in the National League playoff picture with the loss. Against San Diego on Friday, Arizona totaled eight hits as Geraldo Perdomo and Ildemaro Vargas (RBI) each had two. Ketel Marte (his 27th) and Jake McCarthy (his fourth) each went deep in the contest for the Diamondbacks. Zac Gallen (13-15) took the loss as he allowed six runs (five earned) on seven hits with three walks and three strikeouts over 4.1 innings of work.
Brandon Pfaadt takes the mound for the Diamondbacks in the final game of this set as he logs his 33rd start of the season. He is 13-8 with a 5.00 ERA, a 1.326 WHIP, 37 walks and 142 strikeouts over 172.2 innings of work on the year. Pfaadt didn’t factor in the decision in his last start, which came at home against the Diamondbacks Tuesday night. He gave up three runs on four hits with two walks and four strikeouts over six innings in a game the Diamondbacks won 5-4. In his last three starts, Pfaadt has no record with a 3.66 ERA, a 0.92 WHIP, four walks and 13 strikeouts over 19.2 innings of work. Pfaadt makes his ninth career start against the Padres in this contest. He has a 3-2 record with a 3.23 ERA, a 1.225 WHIP, 10 walks and 45 strikeouts over 47.1 innings of work against them. Pfaadt is 1-1 with a 2.92 ERA, a 1.014 WHIP, four walks and 20 strikeouts over 24.2 innings in four career starts at Petco Park.
Padres Readying for Postseason
San Diego got back in the win column as they took the opening game of this series Friday night at home. The Padres entered Saturday 88-72 on the season and stood second in the NL West, three games behind the Dodgers for the top spot. They have clinched at least a wild card spot and trailed the Cubs by two games for the top wild card spot. Against the Diamondbacks on Friday, San Diego finished with 12 hits, with Luis Arraez (run) led the team with four in the game. Fernando Tatis Jr. (his 24th, a grand slam) went deep for the Padres in this contest. Yu Darvish (5-5) earned the win as he threw five innings, allowing two runs on six hits with two walks and four strikeouts, before departing. Mason Miller threw 1.1 scoreless innings, allowing no hits with one walk and three strikeouts, for his 22nd save.
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The Padres have not announced a starter for this one as it could change direction depending on whether they have a chance to earn home-field advantage in the wild-card round or not. This is Nick Pivetta’s turn in the rotation for the Padres as he would make his 32nd start of the year in this contest. He comes in 13-8 with a 2.87 ERA, a 0.985 WHIP, 50 walks, and 190 strikeouts over 181.2 innings of work this season. Pivetta didn’t factor in the decision in his last start, which came against the Brewers at home Monday night. He threw 5.2 innings, allowing three runs on four hits with five walks and five strikeouts in a 5-4, 11-inning, Padres victory. In his last three starts, Pivetta has no record with a 3.12 ERA, a 1.71 WHIP, six walks and 18 strikeouts over 17.1 innings of work. Pivetta makes his sixth career appearance, fifth start, against the Diamondbacks in this contest. He is 2-1 with a 2.96 ERA, a 1.151 WHIP, 10 walks and 28 strikeouts over 24.1 innings of work. Pivetta is 8-2 with a 2.53 ERA, a 0.897 WHIP, 30 walks and 127 strikeouts over 110.1 innings in 19 career appearances, 18 starts, at Petco Park.
Diamondbacks vs. Padres Pick
Moneyline Pick for Diamondbacks vs. Padres
- Diamondbacks (4 units)
This is a lean banking on the fact that a Cubs win or Padres loss Saturday would send San Diego on the road for the wild card round and leave the Padres with nothing to play for here. That would allow the Padres to potentially send someone else to the mound and save Pivetta for Game 1 of their set Tuesday night. Arizona was in the mix for the playoffs until losing Friday night, which eliminated them from playoff contention. Pfaadt has been solid of late and the Diamondbacks are going to go down swinging. Give the advantage to the Diamondbacks as they come up with the victory to head into the offseason.
Over/Under Pick for Diamondbacks vs. Padres
- Under (4 units)
Arizona entered Saturday having seen the over go 77-73-10 in their opening 160 games of the season. The Diamondbacks are fourth in the league in runs per game with 4.91, a number that slides down slightly to 4.75 runs per game on the road on the year. Arizona has an average total of 9.71 runs per game and that number slides down to 9.65 runs per game away from Chase Field. San Diego entered Tuesday night 19th in the majors with 4.28 runs per game while they allow an average of 3.85 runs per contest. That gives the Padres an average total of 8.13 runs a contest. They average 4.39 runs per game at home while allowing an average of 3.42 runs per game, giving them an average total of 7.81 runs per game at Petco Park. San Diego has seen the under post an 86-68-6 mark in their 157 games on the year. Look for runs to come a little harder than normal here and this game winds up under the total.
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