Arizona Diamondbacks vs. San Francisco Giants Picks and Prediction, Tuesday, September 9, 2025
It’s the continuation of a series on the diamond between a pair of NL West foes as the Arizona Diamondbacks play the middle game of a three-game set with the San Francisco Giants Tuesday night and we break it down for you with our Diamondbacks vs. Giants prediction. Arizona fell 7-4 at home against Boston on Sunday to miss a chance at sweeping the three-game interleague series. San Francisco played the rubber game of a three-game series on the road Sunday, falling 4-3. This article was posted prior to the conclusion of the opening game of the set at Oracle Park on Monday night. Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks! Read more about this Diamondbacks vs. Giants prediction!
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Arizona Looking to Earn Road Victory
Arizona missed a chance to sweep Boston at home as they dropped the finale of their set Sunday afternoon. The Diamondbacks entered Monday 72-72 on the year and stood fourth in the NL West, 7.5 games behind the Dodgers for the top spot. They were 4.5 games behind the Mets for the final wild card spot in the National League playoff picture. Against Boston Sunday, Arizona finished with six hits as Gabriel Moreno (run, RBI) was the lone player with two. Ryne Nelson threw six innings, allowing one run on three hits with three walks and three strikeouts, but didn’t factor in the decision. Taylor Rashi (0-1) took the loss in relief as he allowed three runs on two hits with one walk and two strikeouts over 1.2 innings of relief.
Zac Gallen is on the bump for his 30th start of the season for the Diamondbacks in this contest. He is 11-13 with a 4.77 ERA, a 1.28 WHIP, 57 walks and 154 strikeouts over 168 innings of work this season. Gallen earned the win in his last start, which came against the Rangers at home on Wednesday. He threw six innings, allowing no runs on four hits with one walk and five strikeouts in a game the Diamondbacks won 2-0. In his last three starts, Gallen is 2-0 with a 0.50 ERA, a 0.83 WHIP, five walks and 20 strikeouts over 18 innings of work. Gallen makes his 18th career start against the Giants in this contest. He is 7-5 with a 3.75 ERA, a 1.135 WHIP, 31 walks and 111 strikeouts over 96 innings of work against them. Gallen is 2-3 with a 4.26 ERA, a 1.164 WHIP, 16 walks and 59 strikeouts over 50.2 innings in nine career starts at Oracle Park.
Giants Hoping to Gain Ground in NL Wild Card Chase
San Francisco dropped the rubber game of their three-game series with the Cardinals on the road Sunday afternoon. The Giants entered Sunday 72-71 on the year and stood third in the NL West, seven games behind the Dodgers for the top spot. They were four games behind the Mets for the final wild card spot in the National League. Against the Cardinals on Sunday, San Francisco finished with five hits with no player recording more than one. The Giants were three of eight with runners in scoring position and left six runners on base in the game. Kai-Wei Teng (2-4) took the loss as he threw four innings, allowing four runs on three hits with five walks and eight strikeouts.
Robbie Ray takes the hill for the Giants as he makes his 30th start of the season in this contest. He is 10-6 with a 3.31 ERA, a 1.18 WHIP, 65 walks and 171 strikeouts over 168.2 innings of work this season. Ray didn’t factor in the decision in his last start, which came against the Rockies on the road Wednesday. He threw 4.2 innings, allowing five runs (four earned) on seven hits with one walk and eight strikeouts in a game the Giants won 10-8. In his last three starts, Ray has no record with an 8.36 ERA, a 1.93 WHIP, eight walks and 13 strikeouts over 14 innings of work. Ray makes his third career start against the Diamondbacks in this contest. He is 2-0 with a 3.00 ERA, a 0.933 WHIP, four walks and 16 strikeouts over 15 innings of work against them. Ray is 9-8 with a 3.72 ERA, a 1.338 WHIP, 63 walks and 165 strikeouts over 145 innings in 26 career starts at Oracle Park.
Diamondbacks vs. Giants Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,778.00 |
| 2 |  Ross Benjamin | +1,716.00 |
| 3 |  David Hess | +1,326.00 |
| 4 |  Earle Sports Bets | +1,323.00 |
| 5 |  Dan Kaiser | +1,071.00 |
Moneyline Pick for Diamondbacks vs. Giants
- Giants (4 units)
Both teams entered Monday’s opener with losses on the ledger as the Diamondbacks fell to Boston while the Giants dropped back-to-back tilts to the Cardinals. While San Francisco entered Monday a pedestrian 35-34 at Oracle Park on the year, that is better than Arizona’s 34-38 road mark on the season. Ray is 4-3 with a 3.33 ERA, a 1.22 WHIP, 31 walks and 82 strikeouts over 83.2 innings of work at home on the year. The Diamondbacks’ relief corps has been weakened by injuries and we saw it burn them in Sunday’s game. Take San Francisco at home in this contest as Ray beats one of his former squads.
Over/Under Pick for Diamondbacks vs. Giants
- Over (4 units)
Arizona entered Monday having seen the over go 68-67-9 in their opening 144 games of the season. The Diamondbacks are fifth in the league in runs per game with 4.94, a number that slides down slightly to 4.71 runs per game on the road on the year. Arizona has an average total of 9.70 runs per game and that number slides down to 9.52 runs per game away from Chase Field. San Francisco entered Monday having stayed under the total in 70 of their 143 games, with six pushes, on the season. The Giants are 17th in the majors with 4.32 runs per game, a number that falls to 3.97 runs per game at home. San Francisco has an average total of 8.46 runs per game and that number tumbles to 8.10 runs per game at home this season. With Gallen a middle-of-the-road arm on the road and Ray struggling of late, this game goes over the total.
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