Athletics vs. St. Louis Cardinals Picks and Prediction, Wednesday, September 3, 2025
In this Athletics at Cardinals prediction, the Athletics and Cardinals wrap up their three-game interleague series on Wednesday in St.Louis. The Cardinals and Athletics are both out of the playoff hunt with less than a month to go in the season. The pitching matchup on Wednesday will be Athletics’ lefty Jeffrey Springs (10-9, 4.17) taking on Cardinals’ righty Matthew Liberatore (6-11, 4.32). The first pitch is scheduled for 7:45 PM EST. Read on for more in this Athletics/Cardinals prediction, and grab our top MLB predictions to increase your bankroll!
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Athletics fade fest in the West
The Athletics are nearly done with their first season away from Oakland, spending the entire season at the team’s minor league complex in Sacramento. Not surprisingly, the Athletics have been below-average at home this season. On the road, the Athletics have been decent with a .500 mark heading into Tuesday night’s matchup. The Athletics evened their road mark at 35-35 thanks to an 11-3 win on Monday afternoon. JJ Bleday blasted two home runs, and Zack Gelof had three hits and a home run of his own in the easy win.
*This article was written before the conclusion of Tuesday night’s Athletics/Cardinals game.
The Athletics will try to pick up another road win on Wednesday to close out the series, with lefty Jeffrey Springs on the hill. Springs is 10-9 on the season in 28 games, including 13 quality starts. He has allowed 132 hits in 151 innings pitched, one year removed from Tommy John surgery. Springs has an ERA of 4.17 and a WHIP of 1.19 and allowed 26 home runs. He’s walked 34 and struck out 102 batters. The Rays have lost four of Springs’ last five starts. He is 5-4 on the road in 13 starts, with an ERA of 4.73.
Key Injuries: 3B Max Muncy, CF Denzel Clarke, and RP Jack Perkins are out.
Cardinals fade in summer heat
The Cardinals have faded down the standings as the heat of the summer wore on. They’re now in fourth place in the NL Central Division, only ahead of the floundering Pirates. The Cardinals lost their second straight game on Monday afternoon, 11-3, to the Athletics. Starting pitcher Sonny Gray was tagged for 10 hits and seven runs in six innings of work, falling to 12-8 on the season. Ivan Herrera homered for the Cards in a losing effort.
*This article was written before the conclusion of Tuesday night’s Athletics/Cardinals game.
The Cardinals are on track to finish out of the playoffs for the third straight season. They’ll hope to avoid an outright losing season with a strong finish. Righty Matthew Liberatore takes the hill on Wednesday. He has a record of 6-11 on the season in 25 starts, including 10 quality starts. Liberatore has an ERA of 4.32 and a WHIP of 1.32. He has given up 139 hits in 131.1 innings of work, including 16 home runs. Liberatore has walked 48 and struck out 122. The Cardinals have won three of Liberatore’s last five starts. He is 4-5 at home with an ERA of 4.55 in 11 starts.
Key Injuries: RP Riley O’Brien, C Yohel Pozo, 1B Alec Burleson, 2B Brendan Donovan, and RP John King are out.
Cardinals ML (4 units)
The Cardinals have won three of Liberatore’s last five starts. They still are in a position to finish with a winning record this season and should be motivated to make it two straight winning seasons. They are 37-33 at home this season heading into Tuesday’s contest. The Athletics have lost four of Spring’s last five starts. The Athletics have lost three of four games heading into Tuesday’s game. The Cardinals, despite two straight losses, have won three of five games heading into Tuesday. They’ll get it done behind Liberatore and close out the series with a win.
Take the Cardinals with the money line.
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vinciletti | +1,570.00 |
| 2 |  Dan Kaiser | +1,223.00 |
| 3 |  Ross Benjamin | +1,000.00 |
| 4 |  Earle Sports Bets | +916.00 |
| 5 |  David Hess | +706.00 |
Over (5 units)
The Athletics have gone over the total in three straight games heading into Tuesday night’s matchup. Starter Springs has an ERA of 4.17 overall, and it jumps to 4.73 on the road. The Cardinals have gone over the number in three of four games. They have also gone over the number in three of Liberatore’s last five starts.
Take the over.
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