Athletics vs. Boston Red Sox Prediction and Picks - September 16, 2025

By: Dean Whitaker Published 09/16/2025, 07:00 AM ET
Trevor Story looks to lead the Red Sox over the Athletics
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Major League Baseball action on Tuesday evening, and we have an Athletics vs Red Sox prediction ready to roll. The Athletics are out of playoff contention with a 70-80 record, while Boston currently owns the 2nd American League Wildcard slot with an 82-68 mark. The Red Sox lead the season series 2-1. Continue reading to see our Athletics vs Red Sox prediction.

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The A's Have Won 4 In A Row

The Athletics extended their win streak to four straight with a 7–4 victory over Cincinnati on Sunday, powered by four home runs and a 10-hit effort. Colby Thomas went 3-for-4 with a solo shot and two runs scored, while Nick Kurtz and Brent Rooker each launched multi-run homers to break the game open. Luis Morales earned the win, allowing three earned runs over five innings, and Michael Kelly closed it out with a clean ninth for his first save. The club has now won six of its last ten and continues to climb in offensive metrics, ranking 12th in MLB in runs scored and fourth in slugging.

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Brent Rooker leads the team with 29 home runs and 40 doubles, batting .269 and carrying a four-game hit streak into Tuesday. Tyler Soderstrom has driven in 88 runs and ranks top 25 in MLB in RBIs, while Nick Kurtz leads the team with 32 homers and a .510 slugging percentage. Shea Langeliers adds 30 home runs and a .264 average, rounding out a lineup that ranks fourth in slugging (.438), fourth in home runs (211), and fourth in batting average (.255). This group can score in bunches, especially against left-handed pitching, and they’ve hit 13 homers over their last six games.

Jeffrey Springs (10–11, 4.28 ERA) gets the start Tuesday, looking to bounce back after allowing five earned runs to Boston last week. He’s posted 14 quality starts this season and owns a 1.20 WHIP with a .236 opponent batting average. Springs has gone at least five innings in four straight outings and averages 5.4 frames per start, relying on a changeup-heavy arsenal that’s effective against right-handed hitters. He’ll need to keep the ball in the yard and avoid early traffic against a Sox lineup that ranks sixth in MLB in runs and fifth in OBP. If Springs can settle in early, the Athletics have the power to keep pace.

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The Red Sox Closing in On A Wildcard Berth

Boston enters Tuesday’s opener riding a bit of momentum after a 6–4 win over the Yankees on Sunday, where Romy Gonzalez went 2-for-4 with a double and an RBI, and Garrett Crochet struck out 12 over six innings. The Sox have now won three of their last five and sit just one game behind New York in the AL Wild Card race. They’ve hit the under in seven of their last ten and are 4–6 against the spread in that span, with the bullpen posting a 3.12 ERA over the last week. With playoff urgency rising, every game at Fenway carries weight.

Offensively, Boston remains one of the most balanced lineups in the league. Trevor Story leads the team with 24 home runs and 91 RBIs, ranking top 50 in MLB in both categories, while Alex Bregman is riding a six-game hit streak and has 27 doubles, 17 homers, and 43 walks. Jarren Duran continues to set the tone at the top of the order, slashing .333/.449 with 148 hits and ranking 36th in RBI. The Sox rank fifth in batting average (.254), sixth in runs scored (736), and ninth in slugging (.425), with five players posting double-digit home run totals and a team OBP of .324.

Connelly Early (1–0, 0.00 ERA) makes his second career start after a dazzling debut last week—five scoreless innings with 11 strikeouts and just one walk. He held this same opponent to a .250 average and a 1.20 WHIP, mixing a mid-90s fastball with a sharp slider and a deceptive changeup. Early’s 19.8 K/9 rate leads all rookie starters, and his poise on the mound has drawn early comparisons to top-tier lefties. With Boston’s bullpen rested and the lineup trending upward, Early has a chance to solidify his spot in the rotation and deliver another statement outing.

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Athletics vs Boston Red Sox Pick

Athletics vs Red Sox Moneyline Pick

  • Boston -155 (5 Units)

Boston enters Tuesday’s matchup with a clear edge in both form and matchup dynamics. Connelly Early gets the start after blanking this same lineup in his MLB debut—five scoreless innings with 11 strikeouts and just five hits allowed. Backed by a rested bullpen and a lineup that ranks top six in MLB in runs, batting average, and OBP, Early has the tools and support to repeat that success. The Red Sox are 21–14 when favored by -149 or shorter and have won 60% of those games this season. With playoff urgency rising and home-field advantage in play, Boston should control the tempo early.

Offensively, the Sox are built to punish mistakes. Trevor Story leads the team with 24 homers and 91 RBIs, while Alex Bregman enters on a six-game hit streak and Jarren Duran continues to pace the top of the order with a .333 OBP and 148 hits. They’ve hit 173 homers this season and rank eighth in slugging, while striking out less than almost any team in the league. Against Jeffrey Springs, who gave up five earned runs to Boston last week and owns a 4.28 ERA, the matchup leans heavily toward the Sox. If Early delivers another efficient outing and the bats stay hot, Boston should take care of business.

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Athletics vs Red Sox Over/Under Pick

  • Under 9 (4 Units)

Under 9 is a strong play for Tuesday’s matchup, with both pitchers capable of suppressing damage and recent trends pointing toward a lower-scoring outcome. Connelly Early blanked this lineup in his debut, striking out 11 over five innings, and he’ll be backed by a Boston bullpen that’s posted a 3.12 ERA over the past week. Jeffrey Springs, despite giving up five earned runs last time out, still holds opponents to a .236 average and has logged 14 quality starts this season. The Red Sox have hit the under in seven of their last ten games, and the Athletics are 4–6 to the under in that same stretch. With playoff pressure tightening execution and both teams showing streaky run production, this matchup sets up for a 4–3 or 5–2 finish that stays comfortably below the number.

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