Athletics vs. Pittsburgh Pirates, Picks and Prediction, Sunday, September 21, 2025
Use Code WWWC The Athletics (73-81) will be going for the series win when they visit PNC Park on Sunday afternoon to face Pittsburgh (65-89) in the final game of their three-game interleague series at 1:35 PM. ET. Read on to find out which team picks up the win in this Athletics vs. Pirates prediction. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
Jeffrey Springs, 10-11, 4.17 ERA, will get the start for the Athletics. The Pirates will counter with Mike Burrows, 2-4, 4.10 ERA.
The Athletics are 7-3 in their last 10 games against the Pirates.
**This preview was written before Saturday’s game was played.**
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Athletics Going For Fourth Consecutive Series Win
The Athletics played well over the past week, and they’ve won seven of their last eight games. They took the first game of this series and will try to pick up their fourth consecutive series win when they play on Sunday.
The Athletics average 4.60 runs per game, which is 12th in the league. Their .254 batting average is fourth in the league. Their .320 on-base percentage is 12th, while their .435 slugging percentage is third.
Jacob Wilson leads the team with a .317 batting average. Nick Kurtz leads the team with 33 home runs, while Tyler Soderstrom leads the team with 90 RBI.
The Athletics are giving up 5.04 runs per game, which is 27th in the league. Opponents have a .252 batting average against the Athletics, which is 24th in the league. Their 4.69 ERA is 27th, while their 1.36 WHIP is 26th.
In his last start, Springs gave up five hits and one run in four innings, leading to a 2-1 win over Boston.
Pittsburgh Trying To End Slump
The Pirates haven’t played well over the past couple of weeks, and they’ve lost 12 of their last 13 games. With less than 10 games left in the season, they will try to turn things around and close out their season on a positive note, starting with a win on Sunday.
Pittsburgh averages 3.56 runs per game, which is 30th in the league. Their .230 batting average is 28th in the league. Their .305 on-base percentage is 26th, while their .347 slugging percentage is 30th.
Bryan Reynolds leads Pittsburgh with a .243 batting average and 72 RBI, while Oneil Cruz leads the team with 19 home runs.
Pittsburgh is giving up 4.09 runs per game, which is ninth in the league. Opponents have a .237 batting average against the Pirates, which is ninth in the league. Their 3.88 ERA is 12th, while their 1.23 WHIP is sixth.
In his last start, Burrows gave up five hits and three runs in 4.1 innings, leading to a 4-3 loss to Washington.
Athletics vs. Pirates Pick
Money Line Pick for Athletics vs. Pirates
- Athletics ML (4 Units)
The Athletics have won three of their last four road games, while the Pirates have lost seven of their last eight home games. The Athletics have the edge here because they’ve had a lot of success batting against right-handers, and they’re going up against Burrows, who gave up four runs in the last 8.1 innings he pitched.
Pittsburgh won’t be as successful offensively because they’ve struggled against left-handers, and they’re going up against Springs, who gave up four runs in his last three road starts. Take the Athletics to cover the money line.
Over/Under Pick for Athletics vs. Pirates
- Under (4 Units)
The Athletics played under the total in three of their last four games, while the Pirates played under the total in five of their last six games. The Athletics average 4.60 runs per game and averaged 4.33 runs per game in their last three games. They’re batting .253 against right-handers, and they’re facing a starter who gave up four runs in his last three starts. The Pirates average 3.56 runs per game and averaged 2.67 runs per game in their last three games. They’re batting .220 against left-handers, and they’re facing a starter who gave up four runs in his last three road starts. Don’t expect these teams to score enough runs to push the score over the total. The Athletics and Pirates played under the total in three of their last four meetings.
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