Athletics vs. San Diego Padres, Picks and Prediction, Saturday, May 23, 2026

By: Bosun Akinpelu Published 05/23/2026, 04:20 AM ET
Athletics vs. Padres prediction
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The Athletics (26-24) will be trying to increase their lead in the AL West when they visit Petco Park on Saturday night to face San Diego (29-20) in the second game of their three-game interleague series at 9:40 PM. ET. Read on to find out which team picks up the win in this Athletics vs. Padres prediction. Need some winners this baseball season? Check out our Free MLB Picks.

J.T. Ginn, 2-2, 2.98 ERA, will get the start for the Athletics. The Padres will counter with Lucas Giolito, 1-0, 5.40 ERA.

The Padres are 8-2 in their last 10 games against the Athletics.

**This preview was written before Friday’s game was played.**

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Athletics Going For Second Consecutive Series Win

The Athletics snapped their two-series losing streak with a series win over the Angels. They are on top of the AL West standings, 1.5 games ahead of Texas, and will try to increase their division lead when they play the Padres.

The Athletics average 4.48 runs per game, which is 11th in the league. Their .249 batting average is fifth in the league. Their .329 on base percentage is seventh, while their .397 slugging percentage is eighth.

Shea Langeliers leads the Athletics with a .321 batting average and 12 home runs, while Nick Kurtz leads the team with 36 RBI.

The Athletics are giving up 4.56 runs per game, which is 18th in the league. Opponents have a .252 batting average against the Athletics, which is 24th in the league. Their 4.26 ERA is 20th, while their 1.41 WHIP is 24th.

In his last start, Ginn gave up two hits and two runs in eight innings, striking out 10 batters in a 2-1 loss to the Angels.

Padres Trying To Bounce Back From Series Loss

The Padres followed up their series win over Seattle with a series loss to the Dodgers, knocking them into second place in the NL West, 1.5 games behind their rivals. They will try to bounce back from the series loss and pick up their second series win in their last three when they play the Athletics.

San Diego averages 4.08 runs per game, which is 22nd in the league. Their .221 batting average is 30th in the league. Their .292 on base percentage is 29th, while their .366 slugging percentage is 27th.

Xander Bogaerts leads the Padres with a .247 batting average and 23 RBI, while Gavin Sheets leads the team with nine home runs.

San Diego is giving up 4.02 runs per game, which is 10th in the league. Opponents have a .234 batting average against the Padres, which is 11th in the league. Their 3.93 ERA is 13th, while their 1.25 WHIP is 11th.

In his last start, Giolito gave up one hit and three runs in five innings, leading to an 8-3 win over Seattle. He is 1-1 with a 5.01 ERA in four games against the Athletics.

Athletics vs. Padres Picks

Money Line Pick for Athletics vs. Padres

  • Athletics ML (4 Units)

The Athletics have the edge in this game because they’ve been on a roll offensively, and scored 23 runs in their last three road games. They’ve had a lot of success batting against right-handers, and they’re going up against Giolito, who struggled in his first start of the season, and in previous starts against them, giving up nine runs in his last three starts against them. With San Diego’s bullpen also struggling, they will have a hard time slowing down the Athletics.

The Padres will have a hard time keeping up offensively because they’re one of the worst offensive teams in the league, and they’re struggling at the moment, scoring only five runs in their last three games. They’ve struggled against right-handers, and they’re going up against Ginn, who had been solid in recent starts, giving up four runs in his last three starts. He’e been better on the road, giving up only three runs in his last three road starts, so expect him to keep San Diego’s struggling offense in check. Take the Athletics on the money line.

Over/Under Pick for Athletics vs. Padres

  • Under (4 Units)

The Athletics average 4.48 runs per game. They’re batting .252 against right-handers, and they’re facing a starter who gave up 10 runs in his last three home starts against them. The Padres average 4.08 runs per game. They’re batting .222 against right-handers, and they’re facing a starter who gave up three runs in his last three road starts. Don’t expect these teams to score enough runs to push the score over the total.

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