Baltimore Orioles vs Chicago White Sox Picks and Prediction for Wednesday, September 17, 2025
Use Code WWWC On Wednesday, the Baltimore Orioles (70-80, 5th AL East) play the final game of a three-game series on the road against the Chicago White Sox (57-94, 5th AL Central). Baltimore won the opening game of the series 4-1 on Monday, snapping a three-game losing streak. Baltimore is last in the American League East and on the verge of being eliminated from postseason contention. Chicago lost its 4th straight when falling to Baltimore on Monday and has been eliminated from postseason contention. Baltimore will play without 11 pitchers as well as Adley Rutschman and Gary Sanchez. Chicago will play without 10 pitchers as well as position players Nick McLain and Luis Robert Jr. Make sure to read this in-depth Baltimore Orioles versus Chicago White Sox prediction. From first pitch to final inning, our MLB picks for the Baltimore Orioles at the Chicago White Sox prediction keep you covered.
This article was written before these two played on Tuesday.
Baltimore's problems begin but don't end at the plate
The Baltimore Orioles are on the verge of being eliminated from postseason contention for several different reasons, as the Orioles have struggled all season both at the plate and on the mound. The Orioles are 17th in slugging percentage, while 23rd in runs scored, batting average, and on-base percentage. Gunnar Henderson has been Baltimore's most productive hitter this season with 32 (1st) doubles, 5 (1st) triples, 16 (2nd) home runs, and 62 (1st) RBI. Jackson Holliday has also had a productive season, leading the Orioles in home runs with 17 while second in RBI with 55, and doubles with 21. Baltimore has hit 238 doubles, 17 triples, and 177 home runs for 432 extra base hits in 150 games.
On the mound, Baltimore has also struggled this season as the Orioles are 17th in Quality Starts, 25th in ERA, 27th in WHIP, and 28th in batting average against. Tomoyuki Sugano leads Baltimore in wins with 10, while Dean Kremer is the leader in strikeouts with 132. On Wednesday, Baltimore will hand the ball to right-hander Tyler Wells, who this season is 1-0 with a 2.31 ERA, 0.60 WHIP, and 10 strikeouts in limited innings.
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Chicago is performing poorly at the plate and on the mound
The Chicago White Sox have been eliminated from postseason contention, sitting 28.5 games behind first place in the American League Central and have the second-worst record in all of baseball. Chicago is 26th in runs scored, 27th in both on-base percentage and batting average, while 28th in slugging percentage. Chicago's most productive hitter this season has been Lenya Sosa, who leads the White Sox in batting average (.260), home runs (20), RBI (68), and hits (126). Miguel Vargas has also had a productive season with 31 doubles, which leads the club, as well as two triples, 14 home runs, and 53 RBIs. The White Sox have hit 231 doubles, 10 triples, and 151 home runs for 392 extra base hits in 151 games.
On the mound, Chicago is only slightly better than at the plate. The White Sox are 19th in batting average against, 20th in ERA, 25th in WHIP, and 26th in Quality Starts. Davis Martin leads the White Sox in wins with six, and Shane Smith leads in strikeouts with 122. On Wednesday, the White Sox will hand the ball to left-hander Martin Perez, who is 1-5 with a 3.27 ERA, 1.05 WHIP, and 42 strikeouts.
Chicago White Sox vs. Baltimore Orioles Pick
Pick for White Sox vs. Orioles
- Baltimore Orioles (5 units)
With Chicago eliminated from postseason contention and Baltimore on the verge of being eliminated, this matchup is difficult to handicap as several prospects have been called up from the minor leagues to play for both teams, and the focus for both could be on the offseason rather than the moment. However, Baltimore has the advantage due to its starting pitcher performing much better in two outings than Chicago's starter. Baltimore starting pitcher Tyler Wells has made just two appearances this season after spending most of the year on the injured list. The right-hander has pitched just 11.2 innings, giving up six hits and three runs with one win and one no-decision, but Baltimore won both games. Chicago starter Martin Perez has been hit hard in each of his last two outings. The left-hander, across 10.2 innings, allowed nine runs and nine hits with losses to Detroit and Cleveland. Perez had control issues in those two games, walking a total of five hitters, while in the regular season, he has walked a total of just 20.
Over/Under Pick for White Sox vs. Orioles
- Under (4 units)
Both Baltimore and Chicago have performed poorly at the plate this season. The total has finished under in eight of Baltimore's last 10 games. The total has finished under in five of Chicago's last six games, including in Monday’s series opener, when a total of just five runs were scored. Both starting pictures have low WHIPs, which means they walk few hitters and have relatively low ERAs, as Chicago's Perez has a 3.27 ERA and Baltimore’s Wells has a 2.31 ERA.
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