Baltimore Orioles vs. Chicago White Sox Prediction and Picks - September 16, 2025
Use Code WWWC Tuesday evening, Major League Baseball action, and we have a Baltimore Orioles vs Chicago White Sox prediction locked and loaded. The Orioles enter this contest at 70-80 on the year, while the White Sox have the 2nd worst record in the league at 57-94. Continue reading to see our Orioles vs White Sox prediction.
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Orioles Looking To Build Momentum For Next Year
Baltimore snapped a three-game skid with Monday’s 4–1 win, powered by Colton Cowser’s three-run homer and a strong outing from Kyle Bradish. The Orioles held Chicago to just four hits and zero runs after the first inning, improving to 6–4 over their last 10. Cowser now has 14 homers on the season, while Jackson Holliday and Jeremiah Jackson each added key hits. Baltimore’s offense has been streaky, but they’ve hit 176 home runs this year—14th in MLB—and rank 15th in slugging (.399).
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Dean Kremer (9–10, 4.43 ERA) gets the Game 2 start and has quietly closed the season strong, posting a 2.25 ERA over his last four September outings. He’s held opponents to a .196 average on the road and threw three scoreless innings in his most recent start against the Dodgers before exiting with forearm soreness. Kremer has completed six or more innings in 10 of his 24 starts and owns a 1.26 WHIP with 132 strikeouts in 139.2 innings. If healthy, he’s a solid matchup play against a struggling White Sox lineup.
Baltimore’s bullpen has converted 63% of save chances and ranks fourth in holds (98), while the defense has committed just 83 errors all season. With Kremer back and trending upward, the Orioles are well-positioned to clinch the series and keep building late-season momentum.
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Better Luck Next Year, Chicago
Chicago dropped its fourth straight on Monday, falling 4–1 despite an early RBI single from Curtis Mead. The Sox managed just four hits and went 0-for-4 with runners in scoring position, continuing a season-long struggle to generate offense. They’ve now scored just 600 runs this year—26th in MLB—and rank 27th in batting average (.234), 28th in slugging (.375), and 29th in OBP (.303). Lenyn Sosa leads the team with 20 homers and 68 RBIs, but the lineup lacks depth and consistency.
Shane Smith (6–7, 3.78 ERA) takes the mound Tuesday and has been solid, allowing a .212 opponent batting average and striking out 122 in 131.2 innings. He’s gone five-plus innings in seven straight starts and hasn’t allowed an earned run in three of his last seven outings. Smith will need to be sharp against a Baltimore lineup that’s heating up and ranks top 10 in home runs per game. If he can keep the ball in the park and avoid early traffic, Chicago has a chance to stay competitive.
The White Sox bullpen has been a liability, converting just 52.3% of save chances and allowing 32.1% of inherited runners to score. They’ve committed 95 errors and rank 28th in fielding percentage, with defensive lapses often compounding late-inning struggles. With playoff hopes long gone, Chicago is playing for pride and development—but they’ll need a clean outing from Smith and timely hitting to avoid a fifth straight loss.
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Baltimore Orioles vs Chicago White Sox Pick
Orioles vs White Sox Moneyline Pick
- White Sox -126 (4 Units)
Backing the White Sox in Game 2 has merit, especially with Shane Smith on the mound. He’s coming off 5.2 scoreless innings against Tampa and enters with a 3.78 ERA, .212 opponent batting average, and 122 strikeouts in 131.2 innings. Smith has quietly delivered quality starts in three of his last five outings and faces a Baltimore lineup that, while powerful, has been inconsistent on the road. The Orioles are just 9–15 in their last 24 away games and have hit .238 over that stretch. If Smith can keep the ball in the yard and avoid early traffic, Chicago has a path to control tempo and lean on its defense.
Offensively, the White Sox have shown flashes despite their record. Curtis Mead and Lenyn Sosa continue to produce in the middle of the order, and Andrew Benintendi has chipped in 19 homers while slugging .426 over the last month. Baltimore starter Dean Kremer is returning from forearm soreness and may be on a pitch count, which could expose a shaky Orioles bullpen that ranks 22nd in ERA since September 1. With home-field advantage, a rested starter, and a chance to salvage the series, Chicago offers value as a short favorite.
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Orioles vs White Sox Over/Under Pick
- Over 7.5 (4 Units)
The Over 7.5 is in play Tuesday with both starters carrying volatility and each bullpen showing cracks. Dean Kremer returns from forearm soreness and, while sharp in September, has allowed 23 home runs this season and may be on a pitch count. Shane Smith has been solid but faces a Baltimore lineup that’s hit 176 homers and ranks top 15 in slugging. Chicago’s bullpen owns a 4.22 ERA and has converted just 52% of save chances, while both teams have hit the over in more than 40% of their games this season. With warm conditions and defensive lapses on both sides, 5–4 or 6–3 feels well within reach.
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