Baltimore Orioles vs. New York Yankees Picks and Prediction, Friday, September 26, 2025

By: Liam Keating Published 09/26/2025, 10:22 AM ET
Athletics vs Yankees prediction
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It’s an American League East division series to end the regular season on Friday, Sept. 26. Read our Baltimore Orioles vs New York Yankees prediction along with our other MLB Predictions to beat the sportsbooks! The Orioles will miss the postseason with their 74-85 record as they are in last place in the division. The Yankees are still pushing for the divisional title with the Blue Jays struggling down the stretch. The Orioles are set to start ace Trevor Rogers in this outing. These two teams will see it with the first pitch set for 7:05 P.M. EST.

Baltimore will miss postseason action

Baltimore is 74-85 overall this season. They are in last place in the American League East division. They are in last place in the American League East division as they have been out of the playoff race for quite some time. They are below .500 when playing on the road, and they have a 4-6 record when playing the Yankees this season.

Trevor Rogers gets the start for the Orioles in this game. The left-handed pitcher is 9-2 with a 1.35 ERA in 17 starts. His last start saw him throw six innings against the Yankees on Sept. 19. He allowed zero runs and one hit in a 4-2 loss on Sept. 19. The Orioles are 13-4 when Rogers has started this season. He has a 1.66 ERA in 10 starts when pitching on the road. In three starts, he has allowed two runs and 12 hits in 16.1 innings pitched.

The Orioles are hitting .236 this season, which is seventh worst. They have scored the eighth fewest runs, while they rank seventh fewest hits in the sport. They have hit the 14th most home runs while they have struck out the fourth most times. They are hitting 231 on the road and .232 since the All-Star break. They hit .202 in September and .182 in 10 games versus the Yankees.

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Yankees hanging around for AL East crown

New York is 91-68 overall this season. They are tied for first place with Toronto with just three games left on the schedule for the top spot in the AL East. The Yankees have already clinched a playoff spot at the bare minimum, but they will look to push for the division title. The Yankees are 47-31 when playing at home. They have won five straight games. The Yankees have also won eight of their last nine games, along with 11 of their last 14 outings. In their last game, they defeated Chicago White Sox 5-3 to sweep them on Thursday, Sept. 25.

On Friday, Will Warren gets the start for the Yankees. The right-handed pitcher is 8-8 with an ERA of 4.35 in 32 starts. His last game saw him throw 5.1 innings against the Orioles on Sept. 19. He allowed one run and four hits while striking out four batters in a 4-2 loss. The Yankees have lost four straight games when Warren has started. The Yankees are 8-7 when Warren has pitched at home. He has an ERA of 3.28 when pitching at home and an ERA of 3.92 since the All-Star break. He has three starts against Baltimore as he holds a 4.20 ERA against them.

The Yankees are hitting .251 this seaso,n which ranks 11th in the league. They have scored the most runs and the most home runs this year. New York has the 10th most hits, while they have struck out the third most times. New York is hitting .243 at home and .243 since the All-Star break. They have a .255 batting average in September which is their second-best month this season. They are hitting .285 against the Orioles in 10 meetings this season.

Orioles vs Yankees Picks

Money Line Pick for Orioles vs Yankees

  • New York Yankees -1.5 (5 units)

The Yankees are on a heater at the moment, winning five straight games while also winning eight of their last nine games. The rare facing stiff competition in Trevor Rogers, who has a 1.66 road ERA. But, New York’s great lineup should have the offensive firepower at home to steal a few runs. In a low-scoring game, the Yankees will only need a few runs to win and with the division on the line, their clutchness will help them get the victory. The Orioles' offense will be poor in this game as they are hitting just .202 this month and less than .200 against the Yankees this year.

Take the Yankees to cover.Β 

Orioles vs Yankees Over/Under Pick

  • Under 8.5 runs (5 units)

A low-scoring game is expected when the Yankees host the Orioles on Friday night. New York is hitting just .243 at home, while starting pitcher Will Warren has been great inside his own ballpark. He has a home ERA of 3.28 this season. He is facing Baltimore’s Trevor Rogers, who has been great. He has a 1.66 ERA in 10 starts on the road. The Orioles are also hitting just .202 in September.

Take the under on Friday.Β 

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