Baltimore Orioles vs. Toronto Blue Jays Picks and Prediction, Sunday, September 14, 2025 

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On Sunday, the Baltimore Orioles will play the Toronto Blue Jays at Rogers Centre, and we have you ready to go with our Orioles vs. Blue Jays prediction. First pitch is at 1:37 p.m. ET.

The series is tied 5-5 in the last ten matchups between these AL East foes. The over was 7-3 in those ten games. If you want the Orioles vs. Blue Jays prediction, read on and check out our MLB Predictions to beat the sportsbooks!

*Article published before the conclusion of Saturday's game.

Baltimore isn't going down quietly

Baltimore (69-78 SU, 73-74 RL, and 61-79-7 O/U) swept Pittsburgh in its previous series. The Orioles are 8-2 in their last ten games (the under was 7-2-1).

The O's haven't named a probable starter for tomorrow's game against the Blue Jays. Baltimore is expected to use an opener in a bullpen game, per beat reporter Jake Rill. The Orioles' bullpen has a 4.46 ERA and 1.41 WHIP this season.

Baltimore hoped to advance much further this postseason after squandering a terrific regular season with a quick exit in the playoffs, but the first half didn't go as planned (43-52 record). The Orioles' pitching staff has taken a step back with Corbin Burnes gone and Grayson Rodriguez on the IL, posting a 4.59 ERA. The O's lineup is talented, but has only produced 4.3 runs per game (19th). Can they turn it around next season?

Baltimore Orioles Baseball Injury Report: No new injuries to report for Sunday's game against Toronto.

Blue Jays are in a tight division race

Toronto (85-62 SU, 84-63 RL, and 79-63-5 O/U) won two of three games against Houston in its previous series. The Blue Jays are 6-4 in their last ten games (the under went 7-3).

Canada's team will start right-hander Shane Bieber on Sunday against the Orioles. In his last outing, the 30-year-old surrendered three runs on nine hits in 5.2 innings against the Astros. He is 2-1 with a 4.30 ERA and 1.04 WHIP in four starts (23.0 IP) this season, his first with the Blue Jays after spending his first seven seasons with Cleveland.

Toronto wasn't initially viewed as a serious contender in 2025, but it has taken the AL East by storm, taking a three-game lead. The Blue Jays are 54-34 since the start of June, including 29-21 in the second half of the season. They have been especially dominant at home (47-25) and at night (54-30). Can they continue to hold off New York and Boston?

Toronto Blue Jays Baseball Injury Report: No new injuries to report for tomorrow's game against Baltimore.

Orioles vs. Blue Jays Pick

Run Line Pick for Orioles vs. Blue Jays

• Toronto Covers Run Line -1.5 (4 Units)

The Blue Jays have one of the top run line winning percentages as a home favorite, and they are 24-16 RL against AL East opponents. They should have a significant pitching edge in tomorrow's game, as the O's will be going with a bullpen game. Bieber is an experienced pitcher who has held current Baltimore hitters to a .185 BA in the past (29 combined plate appearances). Considering how much Toronto needs to win with New York and Boston right on its tail, I see value in a wager on the home team to cover the run line on Sunday.

Over/Under Pick for Orioles vs. Blue Jays

• Under (4 Units)

Betting Trend: The under is 35-23-3 when the Orioles are road underdogs this season.

Baltimore is 8-2 this month, as its pitching has done the heavy lifting (2.63 ERA). Their lineup is hitting just .209 BA and scoring 3.4 runs per game. Toronto has a high-scoring lineup, but bullpen games can be tricky, as it's challenging to get in quality ABs against several different pitchers. I lean towards the under in Sunday afternoon's game between these AL East rivals.

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