Boston Red Sox vs. St. Louis Cardinals, Picks and Prediction, Saturday, April 11, 2026
Use Code WWWC Boston (4-8) will be trying to pick up their second consecutive series win when they visit Busch Stadium on Saturday night to face St. Louis (7-5) in the second game of their three-game interleague series at 7:15 PM. ET. Read on to find out which team picks up the win in this Red Sox vs. Cardinals prediction. Don’t go down on strikes! Get our top MLB Betting Picks and increase your bankroll! Â
Ranger Suarez, 0-1, 8.64 ERA, will get the start for the Red Sox. The Cardinals will counter with Kyle Leahy, 1-1, 5.40 ERA.
Boston and St. Louis split their last 10 meetings.
**This preview was written before Friday’s game was played.**
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Red Sox Looking For First Road Series Win
The Red Sox followed up their three-game losing streak with two straight wins over the Brewers to pick up their first series win of the season. They lost their first two road series and will try to put an end to the streak with a win over the Cardinals.
Boston averages 3.67 runs per game, which is 21st in the league. Their .226 batting average is 18th in the league. Their .310 on base percentage is 17th, as is their .356 slugging percentage.
Wilyer Abreu has been the most consistent batter for Boston. He leads the team with a .383 batting average, three home runs, and nine RBI.
Boston is giving up 4.58 runs per game, which is 21st in the league. Opponents have a .239 batting average against the Red Sox, which is 17th in the league. Their 4.19 ERA is 20th, while their 1.35 WHIP is 19th.
In his last start, Suarez gave up six hits and four runs in four innings, leading to an 8-6 loss to San Diego. He is 1-0 with a 1.13 ERA in two games against the Cardinals.
Cardinals Going For Second Consecutive Series Win
The Cardinals bounced back from their first series loss of the season with a series win over the Nationals. They will try to keep the momentum going and pick up their second straight series win when they play the Red Sox.
St. Louis averages 4.92 runs per game, which is seventh in the league. Their .226 batting average is 20th in the league. Their .324 on base percentage is 11th, while their .361 slugging percentage is 16th.
Jordan Walker has been the big bat for the Cardinals. He leads the team with a .295 batting average, five home runs, and 12 RBI.
St. Louis is giving up 5.17 runs per game, which is 25th in the league. Opponents have a .268 batting average against the Cardinals, which is 29th in the league. Their 4.95 ERA is 26th, while their 1.52 WHIP is 27th.
In his last start, Leahy gave up five hits and two runs in five innings, leading to a 5-3 win over Detroit. He is 0-0 with a 0.00 ERA in two games against Boston.
Red Sox vs. Cardinals Picks
Money Line Pick for Red Sox vs. Cardinals
- St. Louis Cardinals ML (4 Units)
The Cardinals have the edge here because they’re playing well offensively, averaging more than six runs per game in their last three games. They’ve done well batting against left-handers, and they’re going up against Suarez, who hasn’t looked good on the mound so far, giving up eight runs in his two starts. With Boston’s bullpen also struggling, they will have a hard time slowing down the Cardinals.
Boston will have a hard time keeping up offensively because they haven’t played well on the road, averaging less than three runs per game in their six road games. They’ve also struggled against right-handers, and they’re going up against Leahy, who has done a better job on the mound, giving up six runs in his two starts, so expect him to keep Boston’s offense in check. Take St. Louis on the money line.
Over/Under Pick for Red Sox vs. Cardinals
- Over (4 Units)
The Red Sox average 3.67 runs per game. They’re batting .219 against right-handers, and they’re facing a starter who gave up six runs in two starts, and a team that is giving up 5.17 runs per game. The Cardinals average 4.92 runs per game. They’re batting .271 against left-handers, and they’re facing a starter who gave up eight runs in two starts, and a team that is giving up 4.58 runs per game. Expect these teams to score enough runs to push the score over the total. The Cardinals and Red Sox played over the total in five of their last six meetings.
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