Chicago Cubs vs Milwaukee Brewers, Game 5, Picks and Prediction for Saturday, October 11, 2025
Use Code WWWC The Chicago Cubs visit the Milwaukee Brewers on Saturday to play the 5th and deciding game of their best-of-five National League Division Series. The series is tied 2-2 after Chicago defeated Milwaukee 6-0 on Thursday in Game 4. Milwaukee won each of the first two games of this series played at home, while Chicago held serve at home by winning Games 3 & 4. Chicago will play without four pitchers and catcher Miguel Amaya. Milwaukee will play without seven pitchers as well as position players Garrett Mitchell, Dylan O’Rae, and Ramon Rodriguez. Make sure to read this in-depth Chicago Cubs vs Milwaukee Brewers prediction. Step up to the plate! Check out our free MLB picks for the Chicago Cubs vs. Milwaukee Brewers prediction and swing for the fences.
Chicago must find a way to win on the road
The Chicago Cubs won each of the two games of this NLDS series at home but lost each of the two played in Milwaukee. Chicago's pitching was the big reason the Cubs extended this series to a deciding Game 5, holding Milwaukee to just three hits on Thursday. Matthew Boyd threw 4.2 Innings of shutout baseball, bouncing back from a poor effort in Game 1. The Cubs received three RBIs from Ian Happ, who had a three-run homer in the first inning. Kyle Tucker and Michael Busch also homered for the Cubs.
Michael Busch leads Chicago in home runs during the postseason with four in just seven games played. Busch is tied with two others for the lead in RBI with four and leads in total bases with 19. Nico Hoerner has a team-best 12 hits in seven games, averaging .429. Chicago's pitching staff has performed well during the postseason with a 2.95 ERA and 1.16 ERA. As of the time this article was written, Chicago had not yet announced its starting pitcher for the fifth and final game of the series on Saturday.
Milwaukee must bounce back at home or be eliminated
The Milwaukee Brewers opened their 2025 MLB postseason with two consecutive victories over Chicago, but have since lost two straight and must win at home to move on to the National League Championship Series or be eliminated. Milwaukee was handcuffed at the plate in Game 4 on Thursday with just three hits, which included one double by Sal Frelick and singles by Andrew Vaughn and Jackson Chourio. On the mound, ace Freddy Peralta suffered the loss, allowing three runs on three hits in 4.0 innings pitched.
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During the postseason, Milwaukee has four players who have each hit one home run. Jackson Chourio has been the most productive hitter with two doubles, one home run, and a team-best 6 RBI for a team-high 12 total bases. Chourio is batting .467 to lead the Brewers. As a team, Milwaukee is batting .260 with a .405 slugging percentage in four playoff games. The Milwaukee pitching staff has a 3.97 ERA and 1.32 in this series, while struggling with control, with 17 walks in just 34 innings. As of the time this article was written, Milwaukee had not yet released the name of its starting pitcher for Saturday’s Game 5.
Milwaukee Brewers vs. Chicago Cubs Pick
Spread Pick for Milwaukee Brewers vs. Chicago Cubs
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Milwaukee Brewers -130 (5 units)
The Milwaukee Brewers won each of the first two games of this series at home and return to Milwaukee for Game 5, which will result in a win. The Brewers were 52-29 at home during the regular season and are 2-0 in the postseason. Chicago was 42-39 on the road during the regular season and is 0-2 on the road in the playoffs. Milwaukee is batting .260 during the postseason with a .405 slugging percentage and .738 OPS. Chicago is averaging only .234 at the plate with a .413 slugging percentage and .716 OPS. Dating back to the regular season, Chicago is 0-6 in its last six played on the road, while Milwaukee has won six of its last eight played at home. In all likelihood, Shota Imanaga will start on the mound for Chicago, and the left-hander lasted just 2.2 innings in Game 2 when the Cubs lost 7-3. Milwaukee used its bullpen in Game 2 when beating the Cubs at home, with Aaron Ashby starting. If the same holds on Saturday, the left-hander pitched 1.1 innings, allowing no earned runs before giving way to the bullpen, with the relievers holding the Cubs to 3 runs.
Over/Under Pick for Milwaukee Brewers vs. Chicago Cubs
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Over 7 (4 units)
The over/under through the first four games of this series is 3-1, with both games played in Milwaukee finishing over. The total has finished over in 4 of the last 6 games overall between the two. The Brewers have scored 19 runs in four games of the postseason, averaging 4.75 per game, while Chicago is averaging 3.14,
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