Chicago Cubs vs Milwaukee Brewers Picks and Prediction, Game 3, for Wednesday, October 8, 2025

On Wednesday, the Milwaukee Brewers can clinch the National League Division Series with a victory on the road against the Chicago Cubs in Game 3. Milwaukee leads the series 2-0 after defeating Chicago 7-3 on Monday night. The Brewers have outscored the Cubs 16-6 through the first two games of the series. Milwaukee will play without seven pitchers as well as position players Garrett Mitchell, Dylan O’Rae, and Ramon Rodriguez. Chicago will play without four pitchers and catcher Miguel Amaya. Make sure to read this in-depth Milwaukee Brewers vs Chicago Cubs prediction. Baseball excitement starts here! Dive into our MLB picks for the Milwaukee Brewers vs. the Chicago Cubs prediction.

Milwaukee is performing well both at the plate and on the mound

The Milwaukee Brewers have a team batting average of .343 through two games of the postseason, posting a .529 slugging percentage and a .939 OPS. On the mound, the Brewers are also performing well with a 3.00 ERA and 0.94 WHIP. Milwaukee pitching has allowed just 10 hits and six earned runs in 18 innings, with 23 strikeouts and seven walks.

Jackson Chourio has returned from a late-season injury to perform well in the postseason. Chourio has a .714 batting average in limited plate appearances, with five hits in seven official at-bats. The center fielder has a team-best six RBI and is one of three players for the Brewers with one home run through two postseason games. Andrew Vaughn has 3 RBI, which is second for the Brewers.

Probable starter: Quinn Priester. The right-hander will make his postseason debut. During the regular season, Priester was 13-3 with a 3.32 ERA, 1.24 WHIP, and 132 strikeouts. Milwaukee won two out of three games in which Priester was on the mound this season versus Chicago.

Chicago's back is against the wall as they must win or go home

The Chicago Cubs are struggling both at the plate and on the mound in the postseason. The Cubs are batting just .216 with a .386 slugging percentage and .657 OPS. Chicago's performance on the mound was strong in the wild card series, but the Cubs have struggled through the first two games of the NLDS.

Michael Busch and Seiya Suzuki both have two home runs to lead Chicago during the postseason, while Suzuki has a team-best 4 RBI. Two other players have two RBI each, as Chicago has scored just 12 runs in five postseason games. The Cubs have not scored more than three runs in any of the five playoff games and have been shut out once. Pete Crow-Armstrong is batting just .222 during the postseason, while Ian Happ is batting .105 and Dansby Swanson is batting .176.

Probable Starter: Jameson Taillon. In one postseason appearance, the right-hander gave up just two hits and no runs in 4.0 innings, resulting in a 3-1 victory over San Diego on October 2. Chicago won two of three games against Milwaukee when Tallion was on the mound during the regular season.

Chicago Cubs vs. Milwaukee Brewers Pick

Spread Pick for Cubs vs. Brewers

• Milwaukee Brewers  (4 units)

Milwaukee has produced well at the plate during its first two games in the postseason, as the Brewers are batting .343 with a .539 slugging percentage. Milwaukee has scored 16 runs, while holding Chicago to six runs through the first two games and just 12 runs in 5 postseason games. Dating back to the regular season, Milwaukee has won four of its last six games and 10 of the last 15 games against a team from the National League Central. Chicago has lost three of its last four games, all of which have been played in the postseason. Milwaukee Brewers starting pitcher Quinn Priester faced Chicago three times during the regular season, allowing 10 runs in 14.1 Innings, but seven of the 10 runs were in his first appearance versus Chicago in early May, while the other three runs were spread across two starts and 10.0 innings. Chicago starter Jameson Taillon faced the Brewers three times during the regular season, allowing eight runs in 16 innings.

Over/Under Pick for Cubs vs. Brewers

• Over (4 units)

Both starting pitchers gave up plenty of runs in their three starts during the regular season when the teams played head-to-head. The two games of this series finished over with 12 runs scored in the first and 10 runs in the second. The total has finished over in eight of the last 11 games played between Chicago and Milwaukee