Chicago Cubs vs. St. Louis Cardinals, Picks and Prediction, Sunday, May 31, 2026
Chicago (31-27) will be trying to make up some ground in the NL Central when they visit Busch Stadium on Sunday night to face St. Louis (30-25) in the final game of their three-game series at 7:20 PM. ET. Read on to find out which team picks up the win in this Cubs vs. Cardinals prediction. When it comes to MLB picks, our MLB Predictions are stellar.
Jordan Wicks, 0-1, 16.62 ERA, will get the start for the Cubs. The Cardinals will counter with Matthew Liberatore, 2-3, 4.76 ERA.
Chicago is 6-4 in its last 10 games against St. Louis.
**This preview was written before Saturday’s game was played.**
Cubs Going For Second Consecutive Series Win
The Cubs followed up their 10-game losing streak with two wins in their last three games. They will try to keep the momentum going and pick up their second straight series win when they face the Cardinals.
Chicago averages 4.78 runs per game, which is seventh in the league. Their .239 batting average is 16th in the league. Their .336 on base percentage is second, while their .388 slugging percentage is 15th.
Alex Bregman leads the Cubs with a .260 batting average. Ian Happ leads the team with 13 home runs, while Michael Busch leads the team with 33 RBI.
Chicago is giving up 4.47 runs per game, which is 17th in the league. Opponents have a .239 batting average against the Cubs, which is 14th in the league. Their 4.23 ERA is 17th, while their 1.24 WHIP is eighth.
In his last start, Wicks gave up nine hits and eight runs in 4.1 innings, leading to a 12-1 loss to Pittsburgh.
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Cardinals Trying To End Slump
The Cardinals snapped their four-game losing streak with a win over the Cubs on Friday, which was their second win in their last eight games. They are second in the NL Central standings, with a half-game lead over the Cubs, and will try to increase their lead with a win on Sunday.
St. Louis averages 4.38 runs per game, which is 15th in the league. Their .239 batting average is 17th in the league. Their .318 on base percentage is 14th, while their .388 slugging percentage is 16th.
Jordan Walker has been the most consistent batter for the Cardinals. He leads the team with a .296 batting average, 15 home runs, and 42 RBI.
St. Louis is giving up 4.55 runs per game, which is 19th in the league. Opponents have a .255 batting average against the Cardinals, which is 26th in the league. Their 4.23 ERA is 18th, while their 1.37 WHIP is 22nd.
In his last start, Liberatore gave up seven hits and three runs in five innings, leading to a 5-1 loss to the Brewers. He is 1-1 with a 3.70 ERA in 10 games against the Cubs.
Cubs vs. Cardinals Picks
Money Line Pick for Cubs vs. Cardinals
- St. Louis Cardinals ML (4 Units)
The Cardinals have the edge in this game because they’re playing well offensively at home, and they’ve scored 17 runs in their last four home games. They’ve had success against left-handers, and they’re facing Wicks, who looked terrible on the mound in his first start, giving up eight runs in less than five innings. With Chicago’s bullpen also struggling at the moment, they will have a hard time slowing down the Cardinals.
The Cubs will have a hard time keeping up offensively because they’ve been inconsistent offensively in recent games, and they’re facing Leberatore, who did a decent job on the mound in recent starts, giving up 12 runs in his last four starts. He gave up four runs in his last two starts against the Cubs and will keep their offense in check. Take St. Louis on the money line.
Over/Under Pick for Cubs vs. Cardinals
- Over (4 Units)
The Cubs average 4.78 runs per game. They’re batting .251 against right-handers, and they’re facing a starter who gave up 11 runs in his last three home starts. The Cardinals average 4.38 runs per game. They’re batting .235 against left-handers, and they’re facing a starter who gave up eight runs in his first start. Expect these teams to score enough runs to push the score over the total. The Cardinals and Cubs played over the total in three of their last four meetings.
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