Chicago White Sox at Minnesota Twins Picks and Prediction, Thursday, September 4, 2025
In this White Sox at Twins prediction, the White Sox and Twins wrap up their AL Central four-game set on Thursday in Minnesota. The White Sox are in last place in the division and hoping to avoid a second straight 100-loss season. The Twins are in fourth place in the division, just ahead of the White Sox, and on the verge of their first losing season since 2022. The pitching matchup on Thursday will be White Sox righty Shane Smith (4-7, 3.81) taking on the Twins’ righty Taj Bradley (6-7, 4.82). The first pitch is scheduled for 7:40 PM EST. Read on for more in this White Sox/Twins prediction, and grab our top MLB predictions to increase your bankroll!
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Chicago fighting to finish
The Chicago White Sox are just over ten games from losing 100 games for the second straight season, but they have been fighting over the past month. The White Sox went 12-13 in July, their best month of the season. They followed that up with a 9-19 mark in August. They are 2-0 in September, heading into Wednesday night's game against the Twins. The ChiSox have won each of the first two games of the series in Minnesota, including a 12-3 win on Tuesday night, the team's third straight win overall. Andrew Benintendi led the offensive attack with a 4-for-5 performance, including two home runs and five RBI. The White Sox had 13 hits in the one-sided win.
*This article was written before the completion of Wednesday night’s White Sox/Twins game.
The White Sox come into Wednesday night’s contest with 88 losses on the season but three straight wins. They will turn the ball over to righty Shane Smith in the series finale against the Twins on Thursday. Smith is 4-7 on the season in 26 starts, including six quality starts. He’s allowed 95 hits in 120.1 innings of work. Smith has an ERA of 3.81 and a WHIP of 1.20, and has given up 15 home runs. The White Sox have lost four of Smith’s last five starts. He is 2-4 on the road this season with an ERA of 4.37 in 12 starts.
Key Injuries: 3B Miguel Vargas is out.
Twins sinking after roster overhaul
The Minnesota Twins essentially pulled the plug on the 2025 season after trading away their starting shortstop, center fielder, and three key relievers at the trade deadline. Since then, the team has sunk below .500 and is on the verge of its first losing season in three years. The Twins lost their second straight game and third in fourth on Tuesday night in a 12-3 defeat at the hands of the White Sox. The Twins’ depleted bullpen allowed 11 hits and nine runs over the final four innings to put the game out of reach. Trevor Larnach was the offensive standout for the Twins, going 2-for-4 with an RBI in a losing effort.
*This article was written before the completion of Wednesday night’s White Sox/Twins game.
The Twins now have 76 losses heading into Wednesday night’s contest. They are just 22-32 since the end of June, falling out of the AL Central Division race. They’ll go with recently acquired Taj Bradley in the series finale with the White Sox. Bradley is 6-7 in 23 starts between the Rays and Twins, including 11 quality starts. He has allowed 109 hits in 121.1 innings of work. Bradley has coughed up 15 home runs this year and has an ERA of 4.82 and a WHIP of 1.29. He has walked 48 and struck out 102. The Twins have lost both of Bradley's starts this season, and Bradley has gone 4-3 with an ERA of 5.14 in 12 home starts combined with the Rays and Twins.
Key Injuries: C Christian Vazquez, RP Anthony Misiewicz, SP Pablo Lopez, RP Daniel Duarte, and SP Cory Lewis are out.
Twins ML (4 units)
Bradley has been a hard-luck loser for both the Rays and Twins this season. He has lost both of his starts with the Twins since being acquired in July. The White Sox have won three straight heading into Wednesday, but are just 21-46 on the road this season. Despite their struggles, the Twins are a game over .500 at home this season. White Sox starter Smith has an ERA one run higher on the road than at home. The Twins will take advantage on Thursday and grab a series-closing win over the ChiSox.
Take the Rays with the money line.
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Over (4 units)
Both teams are well out of the race, and each is clearly swinging freely in recent games. The White Sox have gone over the total in four of their last five games. The Twins have been even more prolific offensively, going over the number in each of their last five games. Starter Bradley has gone over the total in three of his last five games overall, and each of his two games with the Twins. Expect more free-swinging from these two lineups on Thursday in Minnesota.
Take the under.
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