Chicago White Sox vs Baltimore Orioles: Picks, Predictions and Props - 6/29/2026

By: Devin Erickson-Sheehy Published 06/29/2026, 10:22 AM ET
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An intriguing American League battle is set to unfold at Camden Yards on June 29, 2026, as the Baltimore Orioles host the Chicago White Sox. This comprehensive preview breaks down the pitching matchups, key player props, and the best betting angles to help you find the edge.

Best Available Odds for White Sox vs Orioles

  • Best Moneyline Odds: Baltimore Orioles -125, Chicago White Sox 125
  • Best Spread Odds: Chicago White Sox +1.5 (-156), Baltimore Orioles -1.5 (+155)
  • Best Total Odds: Under 9.0 (-107), Over 9.5 (+110)

Game Info

  • Date: June 29, 2026
  • Time: 6:35 PM EDT
  • Location: Oriole Park at Camden Yards

Chicago White Sox vs Baltimore Orioles Preview

The Baltimore Orioles look to defend their home turf against the visiting Chicago White Sox in what promises to be a tightly contested matchup. With both teams sending capable right-handers to the mound, this game will likely come down to which lineup can capitalize on key situational opportunities. Baltimore will rely on its home-field advantage to edge out a victory, while Chicago's resilient lineup aims to keep the pressure on from start to finish.

Starting Pitchers and Pitching Matchup

The Chicago White Sox will send right-hander Sean Burke to the mound. Burke has been highly effective against the current Baltimore roster in his career, holding them to a collective .154 batting average and a .247 wOBA over 46 plate appearances. Among individual matchups, Taylor Ward has found the most success against Burke, going 4-for-9 (.444 BA) with a .477 wOBA. Gunnar Henderson has a .200 batting average (1-for-5) but has shown excellent discipline with a 28.6% walk rate. Meanwhile, key Orioles hitters like Jackson Holliday (0-for-5), Tyler O'Neill (0-for-5), and Coby Mayo (0-for-4) have struggled to solve Burke in past meetings.

The Orioles counter with right-hander Shane Baz. White Sox hitters have had limited but highly successful looks at Baz in their careers, batting .467 with a .564 wOBA over 18 plate appearances. Miguel Vargas has hit him hard, going 1-for-3 with a home run, while Chase Meidroth is 2-for-3 (.667 BA). Luisangel Acuña (1-for-3), Andrew Benintendi (1-for-3), and Colson Montgomery (1-for-2) have also recorded hits against Baz, suggesting the Chicago lineup could find early opportunities to put runners on base.

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We expect a highly competitive, low-scoring affair where the Baltimore Orioles utilize their home-field advantage to secure a narrow, one-run victory. Both starting pitchers have shown the ability to suppress opposing bats, which should keep the offenses in check and lead to a tight game flow where the White Sox keep the score within the run line.

Moneyline Pick: Baltimore Orioles (-125)

The Orioles hold the upper hand at home, where they have consistently performed well. While Sean Burke has historically pitched well against Baltimore's hitters, the Orioles' depth and bullpen advantage should allow them to secure a close victory in the later innings. At -125, the moneyline offers solid value for the home favorites to get the job done.

Best Bet - Spread Pick: Chicago White Sox +1.5 (-156)

With the expectation of a tight, low-scoring game, taking the White Sox on the run line at +1.5 is the strongest play on the board. Chicago's hitters have historically fared very well against Shane Baz, which should help them generate enough offense to stay competitive. Expect a one-run game where the White Sox comfortably cover the +1.5 spread.

Total Pick: Under 9.0 (-107)

Both starting pitchers possess the tools to limit explosive innings. Sean Burke's career dominance over the Orioles' roster (.154 opponent batting average) and Baz's ability to navigate tough situations point toward a lower-scoring game. Consistent with our thesis of a tight, defensive battle, the under is the preferred play here.

Top Player Prop Picks for White Sox vs Orioles

Chase Meidroth Over 0.5 Hits (-182): Meidroth has been highly efficient at the plate with a .276 batting average this season and has historically found success against Shane Baz, going 2-for-3 in their career matchups. As the White Sox look to keep this game close, expect Meidroth to jumpstart the offense with at least one hit.

Taylor Ward Over 0.5 Hits (-177): Ward has been a bright spot against Sean Burke, boasting a career .444 batting average (4-for-9) and a .477 wOBA against the right-hander. In a game projected to be a low-scoring battle, Ward's familiarity with Burke makes him a prime candidate to record a hit.

Pete Alonso Over 0.5 Hits (-230): Alonso remains a critical anchor in the Orioles' lineup, hitting this over in 60% of his last 10 games and maintaining a solid .252 batting average this season. He will be vital in helping Baltimore manufacture the few runs needed to secure a narrow home victory.

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