Chicago White Sox vs Cleveland Guardians Picks and Prediction for Sunday, September 14, 2025
Use Code WWWC The Chicago White Sox (57-91, 5th AL Central) play the final game of a three-game series on the road Sunday against the Cleveland Guardians (76-71, 2nd AL Central). Chicago lost to Cleveland in the first game of the series, 4-0 Friday. The White Sox had a short two-game winning streak snapped by the loss. Chicago has been eliminated from playoff contention. With its four-run shutout victory over Chicago on Friday, Cleveland has won two straight and seven of the last eight. The Guardians trail first-place Detroit by 7.5 games in the American League Central and are 3.5 games behind the third and final AL wild card place. Chicago will play without 10 pitchers as well as position players Nick McLain and Luis Robert Jr. Cleveland will play without seven pitchers as well as position players Lane Thomas and Will Brennan. Make sure to read this in-depth Chicago White Sox vs Cleveland Guardians prediction.
This article was written before these two played on Saturday.
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Chicago performs poorly both at the plate and on the mound
The Chicago White Sox are 26th in runs scored with 597, 27th in both batting average at .235 and on-base percentage at .304, while 28th in slugging percentage at .376. Lenya Sosa leads Chicago in home runs (20), RBI (67), hits (124), and batting average (.263). Andrew Benintendi is second in both home runs (19 ) and RBI (60). Chicago has only four active players with 52 or more RBI. The White Sox have hit 228 doubles, 10 triples, and 150 home runs for 388 extra base hits in 148 games.
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On the mound, Chicago is 20th in ERA at 4.22, 21st in batting average against at .247, 25th in WHIP at 1.36, and 26th in Quality Starts with 39. Shane Smith leads Chicago in wins with six and strikeouts with 122. On Sunday, Chicago will hand the ball to Yoendrys Gomez. This season, the right-hander is 3-2 with a 5.05 ERA, 1.51 WHIP, and 45 strikeouts.
Cleveland struggles at the plate but is much better on the mound
The Cleveland Guardians are battling for a playoff spot, trailing the last of three American League wild card places by just 3.5 games with 15 games remaining on the regular season schedule. The Guardians are 27th in runs scored with 574, 29th in both slugging percentage at .370 and on-base percentage at .296, while 30th in batting average at .225. Jose Ramirez leads Cleveland in home runs (28) and RBI (77). Kyle Manzardo is second in home runs (26) and RBI (67). Cleveland has six players with 42 or more RBI. The Guardians have hit 214 doubles, 15 triples, and 151 home runs for 380 extra base hits in 147 games.
On the mound, Cleveland is 8th in ERA at 3.83, 14th in batting average against at .243, 18th in WHIP at 1.29, and 19th in Quality Starts with 49. Tanner Bibee leads Cleveland in wins with 10, while Gavin Williams leads in strikeouts with 152 and ERA for starters at 3.16. On Sunday, Cleveland will hand the ball to Slade Cecconi. This season, the right-hander is 6-6 with a 4.45 ERA, 1.25 WHIP, and 94 strikeouts.
Chicago White Sox vs. Cleveland Guardians Pick
Spread Pick for Chicago White Sox vs. Cleveland Guardians
- Cleveland Guardians -1.5 (5 units)
Chicago has lost 13 of the last 15 versus Cleveland, and the White Sox have lost each of the last five played on the road against the Guardians. Chicago starter Yoendrys Gomez has been hit hard in two of the last three outings, allowing 14 hits and 9 runs in 14 innings over the three starts, while giving up eight of the nine runs in two starts, including the most recent when losing to Tampa Bay 5-4 last Tuesday after allowing five hits and four runs in five innings including serving up a pair of home runs. Cleveland starter Slade Cecconi is coming off a strong outing in which the right-hander threw 8.0 shutout innings, allowing just one hit last Monday when defeating Kansas City 10-2. Chicago has nothing more than pride to play for in this matchup as the White Sox have been eliminated from postseason contention, while Cleveland has far more incentive as the Guardians battle for a wild-card berth in the American League.
Over/Under Pick for Chicago White Sox vs. Cleveland Guardians
- Under (4 units)
The total has finished under in six of Cleveland's last seven games, four of Cleveland's last five games played at home, and four of Cleveland's last five games against a team from the American League. The total has finished over in each of Chicago's last two games, including the first game of this series, when just four runs were scored on a closing line of 7.5.
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