Chicago White Sox vs. Milwaukee Brewers, Picks and Prediction, Saturday, March 28, 2026
Use Code WWWC Chicago (0-1) will be trying to avoid losing their first series of the season when they visit American Family Field on Saturday night to face Milwaukee (1-0) in the second game of their three-game interleague series at 7:10 PM. ET. Read on to find out which team picks up the win in this White Sox vs. Brewers prediction. When it comes to MLB picks, our MLB Predictions are stellar.
Sean Burke will get the start for the White Sox. He was 4-11 with a 4.29 ERA last season. The Brewers will counter with Chad Patrick, who was 3-8 with a 3.53 ERA last season.
Milwaukee is 9-1 in its last 10 games against Chicago.
White Sox Looking For First Win
The White Sox didn’t get their season off to a good start after getting routed by the Brewers in their first game. They will try to bounce back from the loss and pick up their first win of the season when they play on Saturday.
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Chicago scored two runs in their first game. They finished the game with a .129 batting average, a .250 on base percentage, and a .323 slugging percentage.
Munetaka Murakami led the White Sox with a .500 batting average, one home run, and one RBI.
Chicago gave up 14 runs in their first game. They will need a significantly better performance from their pitching staff if they want to win this game.
In his last start, Burke gave up two hits and two runs in 4.1 innings, leading to a 6-5 loss to Washington.
Brewers Going For Second Consecutive Win
The Brewers kicked off their season with a dominant win over the White Sox in their first game. They will try to keep the momentum going and pick up their first series win of the season when they play on Saturday.
Milwaukee scored `14 runs in their first game. They finished the game with a .364 batting average, a .512 on base percentage, and a .606 slugging percentage.
Christian Yellich led the Brewers with a .500 batting average, while Jake Bauers had one home run and three RBI.
The Brewers gave up two runs in their first game. They will need a similar effort if they want to get the win.
In his last start, Patrick gave up one hit and one run in four innings, leading to a 5-1 loss to the Dodgers.
White Sox vs. Brewers Picks
Run Line Pick for White Sox vs. Brewers
- Milwaukee Brewers -1.5 (4 Units)
The Brewers have the edge here because they looked very good offensively in their first game, making solid contact en route to scoring 14 runs in the win. They hit the ball well against right-handers last season, and they’re going up against Burke, who gave up eight runs in his last three road starts. With their bullpen also struggling in their first game, expect them to have a hard time slowing down the Brewers.
Chicago won’t be as successful offensively because they struggled against right-handers last season and picked up where they left off in their first game, batting under .200 in the loss. They’re going up against Patrick, who did a good job on the mound last season and gave up one run in his last two games, so expect their offensive struggles to continue. Take Milwaukee on the run line.
Over/Under Pick for White Sox vs. Brewers
- Over (4 Units)
The White Sox averaged 3.99 runs per game last season. They had a .228 batting average against right-handers, and they’re facing a starter who gave up one run in his last two games, and a team that gave up 3.89 runs per game last season. The Brewers averaged 4.87 runs per game last season. They had a .254 batting average against right-handers, and they’re facing a starter who gave up six runs in his last three starts, and a team that gave up 4.58 runs per game. Expect these teams to score enough runs to push the score over the total. The Brewers and White Sox played over the total in their last five meetings.
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