Chicago White Sox vs. Minnesota Twins Picks and Prediction for Wednesday, September 3, 2025
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Chicago White Sox (50-88) vs. Minnesota Twins (62-75)
The MLB betting action goes on Wednesday, September 3, 2025, with the Chicago White Sox taking on the Minnesota Twins in the AL Central showdown at Target Field in Minneapolis, Minnesota, so we’ve prepared the White Sox vs. Twins prediction to get you covered.
Chicago and Minnesota continue a four-game series at Target Field. The White Sox outlasted the Twins 6-5 in the opener, while the second game has been excluded from this preview. It is their final set of the season, and the teams split their first 10 encounters in 2025. Chicago was looking for its fourth straight win over Minnesota on Tuesday night.
Let’s look closer at this White Sox vs. Twins prediction, one of our MLB picks for Wednesday’s card. The first pitch at Target Field is set at 7:40 PM ET, and the Twins open as -170 moneyline favorites with a total of 8.5 runs.
The White Sox beat the Twins on a bullpen day
The Chicago White Sox outhit the Twins 12-8 in the opening game of this series last Monday and fully deserved to win. Chicago used seven pitchers to get through the game, while Brooks Baldwin and Mike Tauchman hit consecutive run-scoring doubles in the top of the eighth to lift the White Sox over the Twins.
It was Chicago’s second win on the spin and the fifth victory in 10 games. During that 10-game stretch, the White Sox have scored 45 runs on a .261/.303/.410 triple-slash, while their bullpen has amassed a pedestrian 6.00 ERA, 1.64 WHIP, and a .287 batting average against.
Yoendrys Gomez is projected to take the mound at Target Field on Wednesday night. The 25-year-old right-hander carries a 3-2 record with a troublesome 5.20 ERA and 1.54 WHIP in four starts and 12 relief appearances (36.1 innings pitched) with the Yankees, Dodgers, and White Sox in 2025.
Gomez will face the Twins for the second time in his career. Just 10 days ago, Gomez threw 4.2 scoreless innings in an 8-0 blanking of Minnesota. He gave up just two hits and three walks while punching out six. 
The Twins’ shaky for continues
The Minnesota Twins were -185 favorites to beat the White Sox this past Monday. However, Bailey Ober yielded four earned runs through five innings of work, and Justin Topa allowed two more in relief to pick up a loss.
It was Minnesota’s sixth defeat in 10 games. During that stretch, the Twins have scored 53 runs on a .245/.334/.428 slash line, while their bullpen has compiled an ugly 6.87 ERA, 1.88 WHIP, and a .314 batting average against. The Twins are having an awful second half of the season and will miss the playoffs for the second straight year. They were just two games under .500 at the All-Star break.
Zebby Matthews is expected to toe the slab on Wednesday night. The 25-year-old righty is 4-4 with an underwhelming 5.06 ERA and 1.48 WHIP in 12 starts (58.2 IP) this season. He went 2-1 in August, posting a 4.26 ERA and 4.55 FIP in five starts and 25.1 innings of work.
Matthews met the White Sox for the first time in his career 12 days ago. He threw 4.2 innings in a 9-7 victory at Rate Field in Chicago, allowing four earned runs on eight hits and three walks.
Chicago White Sox +1.5 -138 (5 units)
The Twins are favorites for a reason. Their lineup is arguably better than the White Sox’s, but I can’t take Minnesota at -170. Also, I don’t feel comfortable with the runline simply because the Twins’ pitching staff doesn’t breed confidence. Zebby Matthews has registered a 4.87 ERA and 5.34 FIP over his last four starts, and I mentioned how bad the Twins bullpen has been in the last 10 days.
Hereof, I’m backing the White Sox to keep it close. Their bullpen has struggled, too, but Yoendrys Gomez dominated the Twins just 10 days ago.
Over 8.5 Runs -115 (5 units)
These two lineups haven’t impressed against the right-handed pitchers in the last 10 days (Chicago .678 OPS and 87 wRC+, Minnesota .644 OPS and 79 wRC+). However, they could easily get things going in this game. Zebby Matthews has allowed at least three runs in four of his previous six starts, while Yoendrys Gomez will have a tall task to shut the Twins down once more.
I expect the Twins to score a run or two off Gomez this time around. Gomez yielded five runs (four earned) on two hits and six walks through four innings in a 10-2 loss to the Yankees this past Friday. When I add a couple of shaky bullpens to the equation, the over looks like a way to go in this matchup.
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