Chicago White Sox vs. New York Yankees Picks and Prediction for Thursday, September 25, 2025
It’s the final game of a three-game series between American League foes on the diamond in the Bronx as the Chicago White Sox travel to face the New York Yankees Thursday night and we have you covered with our White Sox vs. Yankees prediction. In the opening game of the series Tuesday night, the Yankees drew first blood as they earned a 3-2 triumph to draw first blood. Can the Bronx Bombers maintain momentum or will the White Sox play spoiler? This article was published prior to the conclusion of the middle game of the series at Yankee Stadium on Wednesday night. Read more about this Astros vs. Yankees prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
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Chicago Trying to Throw Wrench in Yankees’ Playoff Plan
Chicago dropped their third straight and their ninth in the last 10 games as they were downed in the opening game of this set Tuesday night. The White Sox entered Wednesday 58-99 and sat in the basement of the AL Central, 27 games behind the Tigers and Guardians for the top spot. They have been eliminated from the AL playoff picture. Against New York, Chicago finished with seven hits as no player had more than one in the contest. Colson Montgomery (his 19th) went deep in the contest for the White Sox in the contest. Shane Smith threw five innings, allowing one run on five hits with four walks and eight strikeouts, but didn’t factor in the decision. Brandon Eisert (3-7) took the loss in relief as he allowed two runs on two hits with two walks and no strikeouts over two-thirds of an inning.
Davis Martin gets the ball for the White Sox as he makes his 26th appearance, 25th start, of the season in this contest. He is 7-10 with a 4.03 ERA, a 1.272 WHIP, 46 walks and 99 strikeouts over 138.1 innings of work this season, Martin earned the win in his last start, which came against the Padres at home Friday night. He threw six innings, allowing three runs on six hits with one walk and four strikeouts in a game the White Sox won 4-3. In his last three starts, Martin is 1-1 with a 3.86 ERA, a 1.102 WHIP, five walks and 10 strikeouts over 16.1 innings of work. Martin makes his third career start against the Yankees in this contest. He has no record with a 3.86 ERA, a 1.50 WHIP, six walks and 10 strikeouts over 8.1 innings of work against them. Martin, in his 51st career major league appearance, 44th start, pitches at Yankee Stadium for the first time here.
Yankees Chasing AL East Lead
New York won their third straight game as they rallied to take the opening game of this set Tuesday night. The Yankees entered Wednesday night 89-68 and stand second in the AL East, one game behind the Blue Jays for the top spot. They have clinched a playoff spot and stand three games ahead of Boston for home-field advantage in the wild-card round. Against Chicago on Tuesday, New York finished with 11 hits as Ben Rice and Jazz Chisholm Jr. (run) each had three to lead the way. The Yankees were three of nine with runners in scoring position and left 11 men on base. Luis Gil threw six innings, allowing two runs on four hits with two walks and three strikeouts, but didn’t factor in the decision. Luke Weaver (4-4) earned the win in relief with 1.1 scoreless innings of work, allowing one hit with no walks and one strikeout.
Carlos Rodon takes the mound in the series finale as he makes his 33rd start of the season for the Yankees. He is 17-9 with a 3.04 ERA, a 1.056 WHIP, 72 walks and 198 strikeouts over 189.1 innings of work on the year. Rodon earned the win in his last start, which came against the Orioles on the road Saturday. He threw seven innings, allowing one run on four hits with one walk and eight strikeouts in a 6-1 Yankees win. In his last three starts, Rodon is 1-2 with a 2.37 ERA, a 0.947 WHIP, three walks and 18 strikeouts over 19 innings of work. Rodon makes his third career start against the White Sox in this contest. He is 2-0 with a 2.25 ERA, a 1.25 WHIP, four walks and 11 strikeouts over 12 innings of work against them. Rodon is 22-10 with a 3.37 ERA, a 1.034 WHIP, 81 walks and 228 strikeouts over 224.1 innings in 39 career starts at Yankee Stadium. 
White Sox vs. Yankees Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Ricky Tran | +4,144.00 |
| 2 |  Nick Parsons | +4,004.00 |
| 3 |  Mark Ruelle | +3,809.00 |
| 4 |  David Delano | +3,245.00 |
| 5 |  The Gold Sheet | +2,352.00 |
Run Line Pick for White Sox vs. Yankees
- Yankees -1.5 (-136) (4 units)
Chicago has struggled through another disappointing campaign as they entered Wednesday on the doorstep of 100 losses on the year. The White Sox are a dismal 25 -51 on the road entering Wednesday and with a lot of youth on their side, it’s tough to expect much from them down the stretch here. Meanwhile, the Yankees are breathing down the necks of the Blue Jays for the top spot in the AL East and that means taking care of business against mediocre teams. New York is 45-31 at home entering Wednesday and with Rodon on the bump, you have to think Aaron Judge and the Bronx Bombers break the bats out in a one-sided beatdown.
Over/Under Pick for White Sox vs. Yankees
- Under 8.5 (4 units)
Chicago went into Wednesday night having seen the under post a 77-72-8 mark in their first 157 games of the season. The White Sox are 28th in the majors in runs per game as they average 3.95 runs per contest. They have an average total of 8.50 runs per game on the season. On the road this season, Chicago is 28th in the big leagues with 3.91 runs per contest and an average total of 8.50 runs per contest. New York has seen the under hit in 78 of their 157 games, with five pushes, this season entering Wednesday. The Yankees are third in the majors by averaging 5.22 runs per game, though they allow 4.29 runs per game, giving them an average of 9.51 runs per game. New York puts up 4.99 runs per game at home, while allowing 4.12 runs per game, giving them an average total of 9.11 runs per contest. We saw five runs in the opener and with the White Sox struggling on the road to score runs, take the under here.
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