Chicago White Sox vs New York Yankees Picks and Prediction for Wednesday, September 24, 2025
Use Code WWWC The Chicago White Sox (58-98, 5th AL Central) play the middle game of a three-game series on the road Wednesday in the Bronx against the New York Yankees (88-68, 2nd AL East). Chicago lost to the San Diego Padres 3-2 on Sunday, dropping two of three to San Diego. The White Sox have lost eight of the last nine and have been eliminated from postseason contention. New York defeated the Baltimore Orioles 7-1 on Sunday, winning three out of four in that series. New York trails first-place Toronto by two games in the American League East and currently holds the first of three AL wild cards. Chicago will play without nine pitchers as well as position players Luis Robert and Nick McLain. New York will play without nine pitchers as well as third baseman Oswaldo Cabrera. Make sure to read this in-depth Chicago White Sox vs New York Yankees prediction. From first pitch to final inningโour MLB picks for the Chicago White Sox at New York Yankees prediction keep you covered.
This article was written before these two played on Tuesday
Chicago must find help at the plate and on the mound during the offseason
The Chicago White Sox are 26th in runs scored, 27th in both batting average and on-base percentage, and 29th in slugging percentage. Lenya Sosa has been Chicago's most productive hitter this season, leading the White Sox in home runs (21), RBI (71), hits (129), and batting average (.259). Andrew Benintendi is a close second in homers with 20, and is also second in RBI was 63. Chicago has just three active players with 57 or more RBI. The White Sox have hit 234 doubles, 10 triples, and 156 home runs for 400 extra base hits in 156 games.
Chicago's struggles continue on the mound, as the White Sox are 19th in ERA, 20th in batting average against, 25th in WHIP, and 26th in Quality Starts. Davis Martin leads Chicago in wins with 7, and Shane Smith leads the White Sox in strikeouts with 129. As of the time this article was written, the Chicago White Sox had not yet announced their starting pitcher for Wednesday's second game of a three-game series with the New York Yankees at Yankee Stadium.
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New York is performing well both at the plate and on the mound
The New York Yankees lead baseball in runs scored and slugging percentage, while 3rd in on-base percentage and 13th in batting average. Aaron Judge has carried the Yankees all season, leading the club in home runs (49), RBI (105), hits (170), on-base percentage (.451), and batting average (.326). Trent Grisham is second in home runs with 33, and Cody Bellinger is second in RBI with 97. New York has three players with 31 or more home runs and five players with 72 or more RBI. New York has hit 249 doubles, 19 triples, and 263 home runs for 550 extra base hits in 156 games.
On the mound, New York is 4th in batting average allowed, 13th in both WHIP and Quality Starts, and 15th in ERA. Max Fried, who will start on the mound Wednesday for New York, leads the Yankees in wins with 18 and in ERA for starters with 2.91. Carlos Rodon is the leader in strikeouts with 198. Fried is 18-5 with a 1.11 WHIP and 182 strikeouts.
Chicago White Sox vs. New York Yankees Pick
Spread Pick for White Sox vs. Yankees
- New York Yankees -1.5 (5 units)
Chicago has lost eight of its last nine, four of its last five on the road, five of its last six overall versus New York, and four of its last five on the road against the Yankees. New York has plenty of incentive to win as the Yankees are battling for first place in the American League East, trailing by two games with six games to play. The Yankees have won five of their last six and seven of their last 10 played at home. New York has the best slugging percentage and has scored the most runs in baseball, and will pound the ball against whoever the White Sox send to the mound on Wednesday. New York has scored between 6 and 10 runs in its five wins over the last six games. New York Yankees starting pitcher Max Fried has had an excellent season with a 2.92 ERA, 1.11 WHIP, and 182 strikeouts, resulting in an 18-5 record. The left-hander has had two consecutive strong outings and four solid outings out of the last five appearances. In his most recent two starts, Fried gave up 12 hits and two runs in 12.1 innings. New York has won each of the left-handerโs last five starts.
Over/Under Pick for White Sox vs. Yankees
- Underย (5 units)
The New York Yankees are scoring plenty of runs, but of late, the pitching staff for New York has stepped up and quieted opponentsโ bats. The total has finished under in four of New York's last five games and in five of the last seven games that New York played against a team from the American League. The total has also finished under in eight of Chicago's last 10 games, and the White Sox have had trouble scoring runs, averaging just 3.96 runs per game this season, which is 26th.
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