Chicago White Sox vs. New York Yankees Picks and Prediction, Tuesday, September 23, 2025
Use Code WWWC It’s an American League battle in the last week of the regular season starting on Tuesday, Sept. 23. Read our Chicago White Sox vs New York Yankees prediction along with our other MLB Predictions to beat the sportsbooks! The poor season for the White Sox is finally coming to a close. They have a 58-98 record as they are in last place in the AL. The Yankees have the top spot in the wild card race and are still fighting for the division crown. The White Sox are set to start Shane Smith while Luis Gil gets the nod for the Yankees. These two teams will meet with first pitch set for 7:05 P.M. EST.
White Sox poor season finally coming to a close
Chicago is 58-98 overall this season. They are in last place in the American League Central division while they also own the worst record in the AL. The White Sox have a 25-50 road record. They have lost eight of their last nine games coming into Tuesday. They have a 1-3 record when facing the Yankees this season.
Chicago is set to start Shane Smith against the Yankees. The right-handed pitcher is 6-8 with a 4.06 ERA in 27 starts. His last start saw him throw 4.1 innings against the Orioles on Sept. 16. He allowed six runs and nine hits in an 8-7 loss on Sept. 16. The White Sox are 8-19 when Smith has started this season. He has a 4.59 ERA in 13 games pitched on the road. Smith has a 3.70 ERA since the All-Star break while he’s also thrown 6.1 innings against the Yankees this season. He allowed two runs and three hits during that outing.
The White Sox are hitting .232 this season, which ranks fourth-worst in the league. They have scored the fifth fewest runs, while they also rank fourth worst in hits. Chicago has hit the eighth fewest home runs, too. They are hitting .234 during road games and .251 since the All-Star break. Chicago has a .226 in September and a .214 batting average in four games against the Yankees.
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Yankees still pushing for divisional title
New York is 88-68 overall this season. They are in second place in the American League East division. The Yankees are two games back of the Blue Jays for the divisional lead. New York holds the top spot in the wild card race as they have a four-game lead over the field. The Yankees have a 44-31 record at home and they have won five of their last six games. The Yankees have also won eight of their last 11 games.
On Tuesday, the Yankees are set to start Luis Gil against the White Sox. He has a 4-1 record and an ERA of 3.33 this year in nine starts. His last start saw him throw 4.2 innings against the Twins on Sept. 17. He allowed four runs and nine hits in a 10-5 win. New York is 6-3 when Gil has started; they also have a 3-1 record when he starts at home. Gil has a 2.11 in four home starts while also owning a 2.70 ERA in three starts in September.
New York is hitting .250 this season, which ranks 13th in the league. They have scored the most runs in the league while they also rank 11th in hits. The Yankees have hit the most home runs while they have also struck out the third most times. They are hitting .241 at home and .240 since the All-Star break. New York is hitting .249 in September and .220 against the White Sox in four games.
White Sox vs Yankees Picks
Chicago White Sox vs New York Yankees Spread Pick
- New York Yankees -1.5 (5 units)
Two teams on two different paths clash for a mid-week series on the final few days of the regular season. The White Sox and their American League-worst record will be the visitors as they have a .214 batting average versus New York this season. They are also hitting .234 on the road as they start Shane Smith, who has a 4.59 ERA this year. The Yankees' offense will hit off of him rather well as they have a .249 batting average this month, and they rank first in runs scored. The Yankees are starting Luis Gil, who has a 2.70 ERA in three starts in September.
Take the Yankees to cover.
White Sox vs Yankees Over/Under Pick
- Over 8.5 runs (5 units)
The offense will lead the way in this game as it should be a high-scoring one in the Bronx. The Yankees have the most runs scored in the league and they are hitting .249 this month. They are facing Shane Smith and his 4.59 ERA on the road. The White Sox are also hitting .251 since the All-Star break as they will have some chances in this one, too.
Take the over on Tuesday.
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