Chicago White Sox vs. Washington Nationals, Picks and Prediction, Sunday, September 28, 2025
Use Code WWWC Chicago (59-101) will be trying to close out their season with a win when they visit Nationals Park on Sunday afternoon to face Washington (65-95) in the final game of their three-game series at 3:05 PM. ET. Read on to find out which team picks up the win in this White Sox vs. Nationals prediction. Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
Shane Smith, 6-8, 3.98 ERA, will get the start for the White Sox. The Nationals have not announced their starter for the game.
Chicago and Washington split their last 10 meetings.
**This preview was written before Saturday’s game was played.**
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Chicago Going For Series Win
The White Sox snapped their five-game losing streak with a win over the Nationals in the first game of the series. Even though they're going to finish the season with the second-worst record in the league, they will try to end it on a positive note with a win on Sunday.
Chicago averages 3.96 runs per game, which is 27th in the league. Their .232 batting average is 27th in the league. Their .301 on-base percentage is also 27th, while their .371 slugging percentage is 29th.
Lenyn Sosa has been the big bat for Chicago. He leads the team with a .263 batting average, 22 home runs, and 75 RBI.
Chicago is giving up 4.60 runs per game, which is 21st in the league. Opponents have a .249 batting average against the White Sox, which is 20th in the league. Their 4.28 ERA is 21st, while their 1.37 WHIP is 27th.
In his last start, Smith gave up five hits and one run in five innings, leading to a 3-2 loss to the Yankees.
Washington Going For Fourth Win In Seven Games
The Nationals followed up their win over the Braves in their series finale with a loss to the White Sox in the first game of this series, giving them three wins in their last six games. They will try to bounce back from the loss and pick up their fourth win in their last six games when they play on Sunday.
Washington averages 4.26 runs per game, which is 20th in the league. Their .243 batting average is 21st in the league. Their .305 on base percentage is 24th, while their .390 slugging percentage is 22nd.
CJ Abrams leads Washington with a .260 batting average, while James Wood leads the team with 30 home runs and 92 RBI.
Washington is giving up 5.54 runs per game, which is 29th in the league. Opponents have a .268 batting average against the Nationals, which is 29th in the league. Their 5.33 ERA is also 29th, as is their 1.45 WHIP.
White Sox vs. Nationals Pick
Money Line Pick For White Sox vs. Nationals
- Chicago White Sox ML (4 Units)
These were two of the worst teams this season. The White Sox have the edge here because they played well offensively in recent games, and they’re going up against a Washington pitching staff that has struggled this season and gave up at least five runs in five straight home games. They gave up 10 runs in the first game of the series and will have a hard time slowing down the White Sox.
Washington won’t be as successful offensively because they struggled offensively in recent home games, and they’re going up against Smith, who did a good job on the mound in recent starts, giving up seven runs in his last three starts. He gave up five runs in his last two road starts and will keep Washington’s offense in check. Take Chicago on the money line.
Over/Under Pick for White Sox vs. Nationals
- Over (4 Units)
The White Sox played over the total in two of their last three games, while the Nationals played over the total in two of their last four games. Chicago averages 3.96 runs per game and averaged 4.67 runs per game in their last three games. They’re batting .232 for the season, and they’re facing a team that is giving up 5.81 runs per game at home. The Nationals average 4.26 runs per game and averaged five runs per game in their last three games. They’re batting .250 against right-handers, and they’re facing a starter who gave up nine runs in his last three road starts. Expect these teams to score enough runs to push the score over the total. The Nationals and White Sox played over the total in three of their last five meetings.
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