Cincinnati Reds vs. St. Louis Cardinals Prediction, Tuesday, September 16, 2025
Use Code WWWC In this Reds at Cardinals prediction, the Reds and Cardinals get set for the middle game of their three-game series in St. Louis. Both teams are out of playoff contention with just two weeks left in the regular season. The pitching matchup in game two will be Reds’ lefty Andrew Abbott (9-6, 2.79) taking on Cardinals’ righty Michael McGreevy (6-3, 4.44). The first pitch is scheduled for 7:45 PM EST. Read on for more in this Reds/Cardinals prediction, and grab our top MLB predictions to increase your bankroll!
Cincinnati will try again in 2026
The Cincinnati Reds are on the verge of another playoff-less season, their fifth straight season out of the playoffs, dating back to 2020. The Reds still have a shot at a winning record but must turn around their current fortunes, losers of three straight games heading into Monday night’s series opener in St. Louis. The Reds were swept by the Athletics in Sacramento this weekend, including a 7-4 loss on Sunday afternoon. Noelvi Marte and Will Benson each homered for the Reds in the loss.
*This article was written before the completion of Monday night’s Reds/Cardinals game.
The Reds are now left to shoot for a winning record with just under two weeks left in the regular season. They’ll try to claim a win on Tuesday night with lefty Andrew Abbott on the hill. Abbott is 9-6 this season in 26 starts, including 11 quality starts. He has allowed 130 hits, including 17 home runs, in 151.2 innings of work. He has an ERA of 2.79 and a WHIP of 1.13 this season. Abbott has walked 42 batters and struck out 136. The Reds have lost three of Abbott’s last five starts. He is 5-2 on the road with an ERA of 3.14 in 11 starts.
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Key Injuries: SP Rhett Lowder, RP Ian Gibaut, SP Brandon Williamson, and LF Tyler Callihan are out.
Cardinals will try to close strong
The St. Louis Cardinals have dropped under .500 and are likely looking at a fourth-place finish in the NL Central Division this season. They went just 13-15 in August and have gone 5-7 in September, heading into Monday night’s series opener against the Reds. The Cardinals ended a five-game skid on Sunday in Milwaukee with a 3-2 win over the Brewers. Jose Fermin went 2-for-3 with an RBI to pace the Cardinals’ offensive attack.
*This article was written before the completion of Monday night’s Reds/Cardinals game.
The Cardinals have a chance to make up some ground on the Reds with a solid series. They’ll go for a win on Tuesday night with right-hander Michael McGreevy on the mound. He is 6-3 in 14 appearances this season, including six quality starts. McGreevy has allowed just 55 hits in 79 innings pitched. He has allowed eight home runs on the season. McGreevy’s ERA is 4.44, and he has a WHIP of 1.23. He has walked 12 batters and struck out 47 on the season. The Cardinals have won three of McGreevy’s last five starts. He is 2-3 at home this season with an ERA of 6.07 in eight games.
Key Injuries: RP Zack Thompson, SS Masyn Winn, and RP Packy Naughton are out.
Reds vs. Cardinals Pick
Money line Pick for Reds at Cardinals
- Reds ML (4 units)
The Reds are in a good position to claim victory on Tuesday night with lefty Abbott on the mound. Abbott is 5-2 on the road this season with an ERA of 3.14. Abbott also has an ERA of just 1.67 in three starts against the Cardinals this season. The Cardinals’ McGreevy has an ERA over 6.00 in eight home starts this season. Teams generally put the ball in play off of him, with 47 strikeouts in just under 80 innings of work. The Reds will get some good swings on Tuesday night and pick up a win.
Take the Reds with the money line.
Over/Under Pick for Reds at Cardinals
- Over (4 units)
The Reds have gone over the number in each of their last two games. They have also gone over the number in five of the last seven games against the Cardinals. The Cardinals have gone over the total in three of McGreevy’s last five starts. The Cardinals have also gone over the number in two of three games heading into the series opener on Monday night.
Take the Over.
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