Cincinnati Reds vs. Milwaukee Brewers Picks and Prediction for Friday, September 26, 2025
Use Code WWWC A pair of National League Central teams open up a three-game weekend series on the diamond to close the regular season in search of a win in Cream City when the Cincinnati Reds travel to take on the Milwaukee Brewers Friday night and we break it down for you with our Reds vs. Brewers prediction. Cincinnati avoided a sweep at home to the Pirates as they won the finale 2-1 on Thursday afternoon. Milwaukee avoided being swept on the road by San Diego as they took the finale 3-1 on Wednesday. In the season series between the teams, the Brewers own a 7-3 edge, including taking two of three on the road August 15-17 in the most recent series between the teams. Read more about this Pirates vs. Reds prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Reds Trying to Battle Into Playoff Field
Cincinnati avoided a sweep at the hands of the Pirates by prevailing on Thursday, but if they miss the playoffs, they’ll lament the two losses to Pittsburgh this week. The Reds went into Thursday night 81-78 and stood third in the NL Central, 15 games behind the Brewers for the top spot. They were one game behind the Mets for the final wild card spot in the National League playoff picture. Against Pittsburgh Thursday, Cincinnati had 10 hits with TJ Friedl (run), Gavin Lux (RBI), Miguel Andujar and Ke’Bryan Hayes each recording two. Nick Lodolo (9-8) earned the win as he threw 6.1 scoreless innings, allowing two hits with one walk and 12 strikeouts. Emilio Pagan worked a 1-2-3 ninth, helped by Noelvi Marte’s robbery of Bryan Reynolds, for his 30th save of the year.
Zack Littell is on the bump for the Reds as he makes his 32nd start of the season overall, 10th with Cincinnati, in this contest. He is 10-8 with a 3.86 ERA, a 1.104 WHIP, 30 walks, 127 strikeouts and 30 homers allowed over 182 innings of work this season. Littell earned the win in his last start, which came at home against the Cubs Saturday night. He threw five innings, allowing two runs on three hits with one walk and four strikeouts in a 6-3 Reds victory. In his last three starts, Littell is 1-0 with a 4.32 ERA, a 0.84 WHIP, two walks and 11 strikeouts over 16.2 innings of work. Littell makes his 12th career appearance, third start, against the Brewers in this contest. He is 0-1 with one save, a 1.71 ERA, a 1.048 WHIP, five walks and 15 strikeouts over 21 innings of work against them. Littell is 0-1 with one save, a 1.93 ERA, a 1.071 WHIP, three walks and five strikeouts over 4.2 innings of work in five career appearances, all in relief, at American Family Field.
Milwaukee Trying to Stay Healthy for Postseason
Milwaukee had dropped three straight and four of their last five games before taking the finale of their set with the Padres on the road Wednesday. The Brewers entered Thursday 96-63 and have clinched the NL Central crown. They held a two-game lead over Philadelphia in the race for home-field advantage in the NL playoffs. Against San Diego in the series finale on Wednesday, Milwaukee finished with 10 hits as Brice Turang (run, RBI) had three while Danny Jansen (run, RBI) added two. Jansen (his 13th) homered in the game for the Brewers. Chad Patrick threw three scoreless innings, allowing two hits with two walks and six strikeouts, but didn’t factor in the decision. Aaron Ashby (5-2) fanned the only hitter he faced to end the sixth inning to pick up the win in relief. Alex Uribe worked a 1-2-3 ninth inning, striking out two, for his sixth save.
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Quinn Priester is on the mound for Milwaukee as he makes his 29th appearance, 24th start, of the year in the middle game of the set. He is 13-2 with a 3.25 ERA, a 1.214 WHIP, 49 walks and 128 strikeouts over 152.1 innings of work this season. Priester didn’t factor in the decision in his last start, which came against the Angels at home Thursday. He threw 5.2 innings, allowing two runs on three hits with two walks and 10 strikeouts in a 5-2 Brewers victory. In his last three starts, Priester is 2-0 with a 3.00 ERA, a 1.00 WHIP, four walks and 21 strikeouts over 18 innings of work. Priester makes his fourth career appearance, third start, against the Reds in this contest. He is 1-0 with a 2.76 ERA, a 1.163 WHIP, nine walks and 13 strikeouts over 16.1 innings of work against them. Priester is 8-2 with a 3.97 ERA, a 1.261 WHIP, 28 walks and 75 strikeouts over 81.2 innings of work in 15 career appearances, 11 starts, at American Family Field.
Reds vs. Brewers Pick
Moneyline Pick for Reds vs. Brewers
- Reds +145 (4 units)
This is more a lean on desperation for the Reds, who stand one game behind the Mets for the final wild card spot in the National League as the season reaches its final weekend. Milwaukee has won just two of their last six entering this one. With Jose Quintana and Brandon Woodruff already on the IL, one has to think that the Brewers will play it safe with Priester and avoid any potential injuries that could take another arm out of the mix. Milwaukee is trying to lock down home-field advantage but Pat Murphy likely prioritizes health over anything at this stage. Cincinnati has a tough staff and Littell has been solid since coming over at the deadline. Look for the Reds to find a way to scratch out the win here.
Over/Under for Reds vs. Brewers
- Under 8.5 (4 units)
Cincinnati entered Friday tied for 14th in the majors, averaging 4.43 runs per game on the season. The Reds allow an average of 4.23 runs per game, giving them an average total of 8.66 runs per contest on the year. They have averaged 4.32 runs per game on the road while allowing an average of 4.30 runs per contest, giving them a total of 8.62 runs per game away from the Great American Ball Park. Cincinnati has seen the under post a 91-58-9 mark in their 159 games in relation to the total on the year. Milwaukee has seen the under post a 78-76-5 mark in their 159 games in relation to the total this season entering Friday. The Brewers are 3rd in the majors in runs per game with 5.01 and that number drops to 4.78 runs per game at home. Milwaukee has seen an average total of 8.92 runs per game this season and that number drops to 8.54 runs per game at American Family Field on the year. With both pitchers solid at run prevention, while the bats aren’t as prolific in their respective home/road splits, take the under here.
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