Cincinnati Reds vs Milwaukee Brewers Prediction and Picks - September 27, 2025
Use Code WWWC National League West Central action on Saturday evening, we have a Cincinnati Reds vs Milwaukee Brewers Prediction ready to go. This is a HUGE series for the Reds as they are currently in a battle with the NY Mets for the Final NL Wildcard slot, while the Brewers come in as the top Seed in the National League. Read on to see our Reds vs Brewers prediction.
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The Reds Keep Their Playoff Hopes Alive
Cincinnati opened the series with a vital 3–1 win on Friday, keeping their postseason push on track. The Reds scratched out nine hits and did their damage late: a sixth-inning rally featured an infield knock by Elly De La Cruz, a run-scoring single from Miguel Andújar, and a sacrifice fly by Tyler Stephenson. Cincinnati’s staff combined to hold Milwaukee to three hits; Connor Phillips earned the win in relief and Emilio Pagán finished it with his 31st save.
That result moved the Reds to 82–78 and into a tie for the final NL Wild Card spot, with Cincinnati holding the tiebreaker edge. With two games left this weekend, every inning matters: the bullpen has been sharp in leverage, and the lineup’s mix of speed and contact—De La Cruz, TJ Friedl, Gavin Lux—has been manufacturing runs when power is scarce. The path is simple: match or beat the Mets’ results and keep stacking outs.
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Saturday’s probable for Cincinnati is left-hander Andrew Abbott, who enters at 9–7 with a 2.80 ERA. Abbott’s ability to change eye levels and limit free passes has kept him deep into games, and his success against left-handed hitters pairs well with a defense that’s converting balls in play. With the Reds needing every edge, expect aggressive baserunning and early-count swings to pressure Milwaukee’s starter.
Brewers Look To Wrap Up Top Seed In National League
Milwaukee dropped the opener 3–1, limited to three hits and a lone third-inning run. Quinn Priester took the loss after allowing three runs across five frames, and the offense couldn’t generate a late push against Cincinnati’s bullpen. The Brewers put a few runners on in the middle innings but couldn’t find the extra-base swing to flip the game.
Even with the setback, Milwaukee sits at 96–64 and has the NL Central wrapped up; the remaining focus is seeding and getting the lineup timed up for next week. William Contreras and Christian Yelich have been steady anchors, but the broader order has cooled, especially in run-scoring spots. The pitching has largely carried the load at home, and the club’s run prevention remains a strength heading into October.
Left-hander Robert Gasser is listed to start Saturday. With a limited MLB sample this year, the emphasis will be on strike throwing and keeping the Reds off balance with his breaking stuff. Milwaukee will look to sharpen situational hitting ahead of the postseason—quality at-bats from Yelich, Contreras, and Brice Turang at the top could set the tone, while the bullpen lines up to cover high-leverage spots if needed.
Cincinnati Reds vs Milwaukee Brewers Giants Pick
Reds vs Brewers Moneyline Pick
- Brewers -147 (4 Units)
The Brewers may have dropped the opener, but they have a favorable spot to respond with Robert Gasser taking the mound. Cincinnati’s lineup has been streaky, and in a must-win scenario the pressure shifts heavily to the young Reds hitters. Milwaukee’s offense, led by Christian Yelich and William Contreras, has been steady enough to generate scoring opportunities, and facing a Reds pitching staff that has struggled with consistency down the stretch should give them chances to cash in.
Milwaukee also has the luxury of a deep bullpen that can shorten games, which pairs well with their strong home-field performance all season. With the NL Central already locked up, the Brewers are free to focus on sharpening their approach heading into October, while the Reds are carrying the weight of their playoff chase. That combination of pitching depth, lineup experience, and situational comfort sets up Milwaukee to take control of Saturday’s contest.
Reds vs Brewers Over/Under Pick
- Under 7.5 (5 Units)
With the total set at 7.5, the Under looks strong given how both teams pitched in Friday’s 3-1 game and the arms lined up for Saturday. Robert Gasser has shown the ability to keep hitters off balance, while Andrew Abbott has been one of Cincinnati’s most reliable starters. Both offenses have been inconsistent in recent weeks, and Milwaukee’s bullpen has been steady at home. With playoff pressure tightening every at-bat, another low-scoring, grind-it-out game is the most likely outcome.
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