Cincinnati Reds vs. St. Louis Cardinals Picks and Prediction for Saturday July 25 2026

The Cincinnati Reds visit the St. Louis Cardinals on Saturday at 7:15 PM ET at Busch Stadium in St. Louis, Missouri. Cincinnati is 47-54 and sits fifth in the NL Central, 16.5 games behind Milwaukee. The Reds have won three of their last five games, including back-to-back victories over Seattle, and are looking to keep that momentum going. St. Louis is 52-50 and sits fourth in the NL Central, 12 games behind the Brewers. The Cardinals have dropped four of their last five games after a 10-6 loss to Arizona and hold a 4-1 lead in the season series entering this matchup. Cash in a winning ticket with our free MLB picks.

Cincinnati Reds Looking to Build on Recent Success

Cincinnati is batting .230 while scoring 423 runs with 777 hits, 134 home runs, a .309 on-base percentage, and a .400 slugging percentage. Sal Stewart leads the offense with 21 home runs and 74 RBIs, while Elly De La Cruz is batting .276 with a .351 on-base percentage and 17 home runs. Spencer Steer has added 16 home runs, and JJ Bleday has contributed 17 home runs with 44 RBIs. The Reds have relied on their power throughout the season, even as consistent contact has been harder to find.

The Reds have posted a 4.56 ERA and a 1.43 WHIP while allowing opponents to hit .248 against them. Hunter Greene gets the start with a 2-1 record, a 6.06 ERA, and a 1.16 WHIP across 16.1 innings. Greene has allowed 14 hits while striking out 26 batters, showing plenty of swing-and-miss ability despite limited innings this season. Cincinnati will need him to miss bats early against a Cardinals lineup that has had success in this matchup.

Injuries: Matt McLain (10-Day IL), Nick Lodolo (15-Day IL), Brandon Williamson (60-Day IL), Blake Dunn (10-Day IL), Tony Santillan (15-Day IL).

St. Louis Cardinals Looking to Stay Above .500

St. Louis is batting .241 while scoring 454 runs with 823 hits, 110 home runs, a .317 on-base percentage, and a .384 slugging percentage. Jordan Walker leads the Cardinals with a .291 batting average, 22 home runs, and 77 RBIs. Alec Burleson is hitting .284 with 15 home runs and 69 RBIs, while JJ Wetherholt has added 15 home runs and Ivan Herrera owns a .366 on-base percentage. St. Louis has received balanced production throughout the lineup and has already won four of the first five meetings with Cincinnati.

The Cardinals have recorded a 4.18 ERA and a 1.34 WHIP while opponents are batting .253 against them. Andre Pallante takes the mound with a 10-6 record, a 4.02 ERA, and a 1.26 WHIP across 105.1 innings. He has allowed 102 hits while striking out 75 batters. Pallante has consistently worked deep into games and gives St. Louis another dependable starter in this divisional matchup.

Injuries: Pedro Pages (Day-to-Day), JoJo Romero (15-Day IL), Ramon Urias (60-Day IL), Max Rajcic (60-Day IL).

Pitching Matchup

Cincinnati Reds – Hunter Greene

Greene is 2-1 with a 6.06 ERA and a 1.16 WHIP over 16.1 innings. He has struck out 26 batters while allowing only 14 hits, showing electric stuff despite the higher ERA. Cincinnati will need Greene to limit free baserunners and work deeper into the game against a familiar division opponent.

St. Louis Cardinals – Andre Pallante

Pallante is 10-6 with a 4.02 ERA and a 1.26 WHIP across 105.1 innings. He has surrendered 102 hits while recording 75 strikeouts and has provided steady innings throughout the season. His durability and experience give the Cardinals an advantage heading into Saturday's game.

Cincinnati Reds vs. St. Louis Cardinals Game Pick

• St. Louis Cardinals

St. Louis has the advantage with the stronger overall record, home-field edge, and success in the season series after winning four of the first five meetings. Pallante has also been more dependable over a much larger workload than Greene, whose limited innings make him more difficult to trust. The Cardinals have received consistent production from Jordan Walker and Alec Burleson, and that balanced offense should create enough scoring chances. Expect St. Louis to win another divisional matchup.

Cincinnati Reds vs. St. Louis Cardinals Over/Under Pick

• Over

Cincinnati has hit 134 home runs this season, while St. Louis has scored 454 runs and has already produced strong offensive performances against the Reds in the season series. Greene's elevated ERA and Cincinnati's 4.56 team ERA could create scoring opportunities for the Cardinals, while the Reds have enough power to answer with runs of their own. With both lineups capable of producing extra-base hits, this matchup will cash above the total by the late innings.