Cleveland Guardians vs Houston Astros Picks and Prediction for Saturday, June 20, 2026

By: Liam Keating Published 06/20/2026, 06:05 AM ET
Guardians vs Astros prediction
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Itโ€™s another big clash in the American League on Saturday, June 20. Read our Cleveland Guardians vs Houston Astros prediction along with our otherย Free MLB Picks on the night.

The Guardians are tied for first place in the American League Central division with a 40-36 record. Cleveland is set to start Joey Cantillo, while Houston is starting Spencer Arrighetti. The Astros are 36-41 and they are in third place in in the AL West. These two teams will meet with first pitch set for 7:15 P.M. EST.

Guardians struggles continue, losing 7 of last 10 games

Cleveland is 40-36 overall this season. They are tied with the White Sox for first place in the American League Central division. The Guardians are 21-19 when playing on the road. The Guardians have lost seven of their last 10 games, too.

Joey Cantillo gets the start for the Cubs. The left-handed pitcher is 5-3 with a 4.38 ERA in 15 starts. Cantillo threw five innings and allowed six hits and one run in a 3-1 win to the Tigers. The Guardians are 11-4 when Cantillo has pitched this season. They have won seven of his last nine appearances. He has a 4.93 ERA in eight road games. He owns a 4.02 ERA in 11 games against fellow American League teams.

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The Guardians are hitting .229 this season, which ranks 28th in the league. They rank 27th in runs scored and 28th in hits. The Guardians rank 25th in home runs, while they rank eighth in strikeouts. Cleveland is hitting .219 when playing on the road. They are hitting .215 in June. The Guardians are also hitting .228 against AL West opponents.

Astros finding form, winning four of last six games

Houston is 36-41 overall this season. The Astros are 3.5 games back of the Mariners for the top spot in the American League West division. Houston is also 19-20 when playing at home. The Astros have won four of their last six games coming into this matchup. Houston has won three of their last four games against the Guardians.

On Saturday, Spencer Arrighetti gets the start for the Astros. The right-handed pitcher is 7-2 with a 2.57 ERA in 11 starts. He threw six innings in his last start against the Royals on June 14. Arrighetti eight hits, four run and struck out seven batters in the teamโ€™s 4-0 loss to Kansas City. The Astros are 9-2 when Arrighetti has started. He owns a 2.22 ERA in four starts at home this season. He also has a 2.55 ERA against other American League clubs.

The Astros are hitting .243 this season, which ranks 17th in the sport. They rank 12th in runs scored, but they rank 12th in total hits. The Astros rank fifth in home runs hit, while they have struck out the 15th fewest times. Houston has a .233 batting average at home, while they have hit .240 in June.

Cleveland Guardians vs Houston Astros Picks

Guardians vs Astros Spread Pick

  • Take the Astros to cover (5 units)

This will be a pitcherโ€™s duel in Texas. The Astros are set to start Spencer Arrightetti, who has a 2.22 ERA at home. Joey Cantillo gets the nod for Cleveland, as the Guardians are 11-4 when pitches this season. With very few chances for either side, Iโ€™m going to take the team that has shown more offensive consistency and thatโ€™s the Astros. They rank 12th in runs credo and have hit the fifth most home runs. The Guardians rank third-worst in batting average and fourth-worst in runs scored.

Take the Astros to cover.

Guardians vs Astros Over/Under Pick

  • Take the under (5 units)ย 

The two pitchers have been excellent this season. Spencer Arrightetti has a 2.22 ERA at home and Joey Cantillo has a 4.02 ERA against the American League. Both offenses have not been good enough, which has led to records that are hoping to improve. But, the pitching has been excellent, which will be a low scoring game.

Take the under on Saturday.

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