Cleveland Guardians vs. Minnesota Twins - Game 1 Picks and Prediction for Saturday, September 20, 2025
Use Code WWWC It’s the second game of a weekend series on the diamond and the first game of a doubleheader between a pair of American League Central teams in the Twin Cities as the Cleveland Guardians square off with the Minnesota Twins Saturday afternoon and we have you covered with our Guardians vs. Twins prediction. Cleveland swept Detroit on the road in their previous series, winning the finale 3-1 on Thursday. Minnesota dropped the rubber game of a three-game road set with the Yankees, falling 10-5 on Wednesday. This article was published prior to the conclusion of the opening game of the set at Target Field Friday night. Read more about this Guardians vs. Twins prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Guardians Trying to Chase Down Playoff Spot
Cleveland won their seventh straight and 12th in 13 games as it swept Detroit by winning the finale on Thursday. The Guardians entered Friday 81-71 and stood second in the AL Central, 3.5 games behind the Tigers for the top spot. They were 1.5 games behind Boston for the final wild card spot in the American League playoff picture. Against Detroit Thursday, Cleveland finished with 10 hits as Jose Ramirez (run, two RBI), Jhonkensy Noel (run, RBI) and Bryan Rocchio each had two. Ramirez (his 29th) and Noel (his fifth) each went deep in the win for the Guardians. Tanner Bibee (11-11) earned the win as he threw six innings, allowing one run on four hits with two walks and eight strikeouts. Hunter Gaddis threw a scoreless ninth, allowing one hit with no walks or strikeouts, for his third save.
Logan Allen gets the ball for the Guardians as he makes his 29th career appearance, 28th start, of the season in this contest. He is 7-11 with a 4.36 ERA, a 1.434 WHIP, 59 walks and 111 strikeouts over 144.1 innings of work on the year. Allen didn’t factor in the decision in his last start, which came against the Royals on September 10. He threw five innings, allowing two runs (one earned) on six hits with no walks and two strikeouts in a game the Guardians dropped 4-3. In his last three starts, Allen is 0-1 with a 4.50 ERA, a 1.44 WHIP, five walks, and 11 strikeouts over 16 innings of work. Allen makes his fifth career start against the Twins in this contest. He is 2-0 with a 2.61 ERA, a 1.403 WHIP, six walks and 17 strikeouts over 20.2 innings of work against them. Allen is 1-0 with a 4.00 ERA, a 1.556 WHIP, three walks and seven strikeouts over nine innings in two career starts at Target Field.
Minnesota Playing Out the String
Minnesota dropped its second straight and fourth in the last five games as it dropped the rubber game of their three-game set with the Yankees on Wednesday. The Twins entered Friday fourth in the AL Central with a 66-86 mark, leaving them 18.5 games behind the Tigers for the top spot. They have been eliminated from playoff contention. Against New York on Wednesday, the Twins banged out 11 hits with Brooks Lee (run, two RBI) leading the way with three. The Twins were four of 12 with runners in scoring position while leaving seven runners on base in the contest. Taj Bradley (6-8) took the loss as he allowed seven runs on eight hits with three walks and four strikeouts over four innings of work.
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Joe Ryan is on the mound for the Twins as he makes his 30th appearance, 29th start, of the season. He is 13-8 with a 3.35 ERA, a 1.019 WHIP, 36 walks, 180 strikeouts and 12 hit batters over 161 innings of work on the year. Ryan didn’t factor in the decision in his last start, which came at home against the Diamondbacks last Saturday. He threw four innings, allowing two runs on four hits with two walks and four strikeouts in a game the Twins dropped 5-2 in 10 innings. In his last three starts, Ryan is 1-1 with a 4.85 ERA, a 1.54 WHIP, seven walks and 14 strikeouts over 13 innings of work. Ryan makes his 12th career appearance, 11th start, against the Guardians in this contest. He threw six innings, allowing four runs on six hits with no walks and five strikeouts in a game the Twins dropped 5-4. Ryan is 26-16 with a 3.61 ERA, a 1.028 WHIP, 77 walks and 385 strikeouts over 327 innings in 58 career appearances, 57 starts, at Target Field.
Guardians vs. Twins Pick
Moneyline Pick for Guardians vs. Twins
- Guardians (4 units)
Cleveland has been scorching of late, with 12 wins in their last 13 games, and has charged into playoff contention. The Guardians come in off the sweep of the Tigers on the road to give them a world of momentum. Minnesota has been disappointing all season and Ryan has struggled of late on the mound, posting a 1-3 record and a 7.36 ERA over 22 innings in his last five starts. The Twins are at home but that isn’t anything to write home about as they are 37-40 at Target Field. Look for Cleveland to take care of business as they stay hot, dealing the sinking Twins another defeat.
Over/Under Pick for Guardians vs. Twins
- Under (4 units)
Cleveland entered Friday having stayed under the total in 79 of their 152 games, with five pushes, on the season. The Guardians are 27th in the majors with 3.91 runs per game, a number that climbs to 3.99 runs per game on the road. Cleveland has an average total of 7.97 runs per game and that moves slightly to eight runs per game on the road this season. Minnesota entered Friday with the over posting a 73-70-9 mark in their opening 152 games of the year. The Twins are 18th by averaging 4.30 runs per game, a number that bumps up to 4.48 runs per game at home. Minnesota has an average total of 9.17 runs per game on the season and that climbs to 9.58 runs per game at Target Field. While the Twins have struggled in run prevention, the Guardians aren’t a prolific offensive attack. Lean toward the under here as a result.
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