Cleveland Guardians vs. Toronto Blue Jays Picks an Prediction for Saturday, April 25, 2026
Use Code WWWC A pair of American League teams take the field North of the border when the Cleveland Guardians face the Toronto Blue Jays Saturday afternoon in the middle game of a three-game set and we have you covered with our Guardians vs. Blue Jays prediction. Cleveland dropped the rubber game of their three-game set with the Astros Wednesday, 2-0, at home Wednesday in their previous contest. Toronto missed the chance to sweep the Angels on the road as they fell 7-3 in the finale Wednesday. This article was published prior to the conclusion of the opening game of the series at Rogers Centre Friday night. Read more about this Guardians vs. Blue Jays prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Guardians Look to Maintain Position in AL Central
Cleveland dropped two of three to Houston at home as they were blanked in the rubber game Wednesday. The Guardians entered Friday 14-12 and tied with the Tigers for the top spot in the AL Central race. Against Houston Wednesday, Cleveland finished with five hits as Chase DeLauter was the lone player with two. The Guardians went zero for six with runners in scoring position and left nine men on base in the contest. Tanner Bibee (0-3) took the loss despite a quality start as he threw six innings, allowing two runs on five hits with two walks and three strikeouts, before departing.
Joey Cantillo takes the ball and makes his sixth start of the season for the Guardians here. He is 1-0 with a 3.20 ERA, a 1.30 WHIP, 12 walks and 30 strikeouts over 25.1 innings of work this season. Cantillo didn’t factor in the decision in his last start, which came at home against the Orioles Sunday. He threw 4.2 innings, allowing four runs (three earned) on five hits with three walks and six strikeouts in a game the Guardians won 8-4. In his last three starts, Cantillo is 1-0 with a 3.31 ERA, a 1.286 WHIP, seven walks and 19 strikeouts over 16.1 innings of work. Cantillo didn’t factor in the decision in his lone career appearance against the Blue Jays, which came in relief on May 2, 2025. He retired the only hitter he faced in a 5-3 Guardians loss. Cantillo made that appearance at Rogers Centre, giving him a passing familiarity with the ballpark.
Toronto Trying to Climb in AL East
Toronto saw their three-game win streak snapped as they were downed in the finale of their set with the Angels Wednesday on the road. The Blue Jays entered Friday 10-14 and stood fourth in the AL East, 5.5 games behind the Yankees for the top spot. Against the Angels, Toronto rapped out 12 hits as Ernie Clement (RBI) had three. Nathan Lukes (run, RBI) and Andres Gimenez (run) each added a pair in the loss. Eric Lauer threw five innings, allowing three runs on seven hits with two walks and three strikeouts, but didn’t factor in the decision. Tommy Nance (0-2) took the loss in relief, allowing two runs on one hit with one walk and two strikeouts in 1.1 innings of work.
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Kevin Gausman is on the bump for his sixth start of the season for the Blue Jays in this contest. He is 1-1 with a 2.54 ERA, a 0.953 WHIP, six walks and 35 strikeouts over 28.1 innings of work on the year. Gausman picked up the win in his last start, which came Sunday at home against Arizona. He threw six innings, allowing two runs on seven hits with one walk and four strikeouts in a 10-4 Toronto win. In his last three starts, Gausman is 1-1 with a 3.86 ERA, a 1.47 WHIP, six walks and strikeouts over 16.1 innings of work. Gausman makes his 12th career appearance, 11th start, against Cleveland in this contest. He is 5-5 with a 2.30 ERA, a 0.975 WHIP, 16 walks and 65 strikeouts over 66.2 innings of work against them. Gausman is 23-26 with a 3.97 ERA, a 1.243 WHIP, 116 walks and 481 strikeouts over 442.1 innings of work in 79 career appearances, 76 starts, at Rogers Centre.
Guardians vs. Blue Jays Pick
Moneyline Pick for Guardians vs. Blue Jays
- Blue Jays -135 (4 units)
Neither team has been overwhelmingly good in the first month of the season and look to turn things around as we near the end of April. Both pitchers have been sound so far though Gausman has a better track record to lean on as far as sustained success. Gausman also is familiar with the Guardians’ lineup and has plenty of experience at Rogers Centre in his career. Cantillo has faced exactly one batter in a Toronto uniform in his career. Cleveland was 6-7 on the road entering Friday night. Expect Gausman to turn in a solid outing and deliver a win for the hosts here.
Over/Under Pick for Guardians vs. Blue Jays
- Under 8 (4 units)
Cleveland entered Friday having seen the under post a 13-13 mark in their 26 games on the year. The Guardians are 23rd by averaging 4.04 runs per game and that number slides to 3.92 runs per game on the road. Cleveland has an average total of 8.31 runs per game on the year, though that jumps to 9.07 runs a night as the visiting team. Toronto has seen the over post a 12-12 mark on the year entering Friday night. The Blue Jays are 23rd in the majors with 3.96 runs per game and that number edges up to 4.17 runs per game at Rogers Centre. Toronto has an average total of 8.96 runs per game but that number climbs to 9.84 runs per game at home. With that said, neither team is setting the world on fire at the plate. Lean toward the under here as a result.
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