Colorado Rockies vs San Diego Padres Picks and Prediction for Friday, September 12, 2025
On Friday, the Colorado Rockies (40-106, 5th NL West) play game two of a four-game series on the road in Southern California versus the San Diego Padres (79-67, 2nd NL West). Colorado lost to the Los Angeles Dodgers 9-0 on Wednesday and was swept in its three-game series with LA. The Rockies have lost five straight and have been eliminated from playoff contention. San Diego lost to the Cincinnati Reds 2-1 on Wednesday. San Diego lost two out of three to Cincinnati. The Padres trail first-place Los Angeles by three games in the NL West and currently hold the second of three NL wild card places. Colorado will play without seven pitchers as well as position players Warming Bernabel, Kris Bryant, and Thairo Estrada. San Diego will play without five pitchers and shortstop Xander Bogaerts. Make sure to read this in-depth Colorado Rockies vs San Diego Padres prediction. Chasing wins? Get the edge with our MLB picks for the Colorado Rockies vs. San Diego Padres prediction right now.
This article was written before these two played on Thursday.
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Colorado is poor at the plate and even worse on the mound
The Colorado Rockies are 23rd in batting average at .239, 24th in slugging percentage at .390, 29th or next to last in runs scored with 545, and 30th or last in on-base percentage at .296. Hunter Goodman has been Colorado's most productive hitter all season, leading the Rockies in home runs (30), RBI (87), hits (135, and batting average (.282). Mickey Moniak is second in both home runs with 19 and RBI with 57. Colorado has hit 234 doubles, 35 triples, and 144 home runs for 413 extra base hits in 146 games.
On the mound, Colorado is 29th in Quality Starts with 31, while 30th in each of the following: ERA at 6.01, WHIP at 1.60, and batting average against at .299. Tanner Gordon, who will start on the mound Friday for Colorado, leads the Rockies with five wins, and Kyle Freeland is the leader in strikeouts with 112. Gordon is 5-6 with a 6.60 ERA, 1.60 WHIP, and 46 strikeouts
San Diego is above average at the plate and even better on the mound
The San Diego Padres are 9th in both batting average at .251 and on-base percentage with .321, while 23rd in runs scored with 617 and 26th in slugging percentage at .386. Manny Machado leads San Diego in both home runs with 23 and RBI with 84. Fernando Tatis Jr is second in home runs with 21, and Gavin Sheets is second in RBI with 64. San Diego has six players with 52 or more RBI. The Padres have hit 238 doubles, 18 triples, and 128 home runs for 384 extra base hits and 146 games
On the mound, San Diego is first in batting average against at .226, third in ERA with 3.65, 4th in WHIP with 1.21, and 21st in Quality Starts at 45. Nick Pivetta leads San Diego in wins with 13 and ERA for starters at 2.73. On Friday, San Diego will hand the ball to Dylan Cease. This season, the right-hander is 7-11 with a 4.71 ERA, 1.34 WHIP, and 195 strikeouts. Cease’s 195 strikeouts lead the Padres.
Colorado Rockies vs. San Diego Padres Pick
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Earle Sports Bets | +2,298.00 |
| 2 |  Ross Benjamin | +1,840.00 |
| 3 |  Rob Vincilleti | +1,757.00 |
| 4 |  David Hess | +1,745.00 |
| 5 |  Dan Kaiser | +987.00 |
Spread Pick for Colorado Rockies vs. San Diego Padres
- San Diego Padres -1.5 (5 units)
Colorado is the worst in baseball against the runline at 60-86, while San Diego is 5th at 80-66. Colorado has lost each of the last five, eight of the last nine played on the road, and seven of the last nine head-to-head against San Diego. The Padres have won five straight at home versus Colorado, and last week won two of three on the road versus the Rockies. San Diego’s pitching will shut down the poor-hitting lineup for Colorado, as the Padres are 3rd in ERA and 4th in WHIP, while Colorado is 23rd in batting average and 29th in runs scored. Colorado starting pitcher Tanner Gordon was roughed up last time out, allowing six hits and six runs in 3.2 innings, resulting in an 8-1 loss last Sunday to San Diego. Padres’ starter Dylan Cease has had two consecutive strong outings, allowing nine hits and three runs across four Innings, including giving up four hits and one run in five innings last Sunday when defeating Colorado 8-1.
Over/Under Pick for Colorado Rockies vs. San Diego Padres
- Under (4 units)
The total has finished under in seven of Colorado's last eight games played on the road, five of San Diego's last six games overall, and four of San Diego's last five games against a team from the National League. Last week, in three games between these two, the total finished under in two of the three, including an 8-1 victory by San Diego last Sunday, with both of the starting pitchers in that game starting on Friday.
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