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Colorado Rockies vs. San Diego Padres Picks and Prediction for Thursday, September 11th, 2025

By: Adam Rauzino Published 09/11/2025, 10:18 AM ET
Colorado Rockies vs. San Diego Padres prediction.

The Colorado Rockies (40-105, 60-85 RL, 62-78-5 O/U) take on the San Diego Padres (79-66, 80-65 RL, 61-78-7 O/U) as the rivals begin a three-game series on Thursday evening, and we have the prediction. The Rockies are sending McCade Brown to the mound. The Padres will answer with Randy Vasquez. The Padres lead the season series 7-2.

Can the Padres win this home game in a blowout on Thursday? Keep reading for the Rockies vs. Padres prediction. Nobody does it better when it comes to MLB Picks!

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Brown Seeks First Career Win

McCade Brown will get the nod for the Rockies. Brown was pelted again in his recent effort, squandering six runs in only 1.2 innings against this San Diego team. The rookie has struggled in all three outings this season, surrendering 13 runs in only 9.1 innings, resulting in a 12.54 ERA, a putrid 2.36 WHIP, and an 0-3 record. Brown did have success in the minor leagues, delivering a sharp 2.47 ERA and a 1.07 WHIP in 76.2 innings this season.

The Colorado Rockies continue to struggle on the mound and rarely win games. The offense has been decent and has improved in the second half, but there are no signs of improvement on the mound heading into next season. They dropped two of three against the Padres last week and dropped the opening two games of their series against the Dodgers this week, entering Wednesday's game. They conceded 10 runs in the first two games. The Rockies are 17-53 on the road.

Mickey Moniak is having the best season of his career. The 27-year-old outfielder has 19 homers with 57 RBIs and a .795 OPS. He has two RBIs in September. Hunter Goodman continues to have a monster season. The 25-year-old catcher already has 11 RBIs this month. Goodman has bashed 30 bombs with 87 RBIs on the season. Brenton Doyle has been quiet, posting a .536 OPS this month. The veteran has 55 RBIs and a .679 OPS. Jordan Beck has been a tough out against the Padres, amassing five RBIs and a .910 OPS. Beck has managed 50 RBIs and a .771 OPS on the season.

Colorado is averaging 3.76 runs per game, ranking them 29th. The pitching is horrid, posting a 6.00 ERA, pegging them 30th.

Vasquez Gets the Nod to Begin Series

Randy Vasquez is on the rubber on Thursday. Vasquez was sharp in his recent outing, conceding two runs in six innings pitched against the Rockies, and secured the win. The veteran has spent time in Triple-A and with the big club. He has been mediocre, sporting a 3.91 ERA and a 1.38 WHIP in 117.1 innings of work on the season. Vasquez has kept Colorado to five runs in 12 innings this season but has issued a weak 5.40 ERA with a 2-1 record in 23.1 career innings against the rivals.

The San Diego Padres have been hit or miss this month. They remain two games behind the Dodgers atop the division. San Diego recently dropped five games in a row. They ended the slide by winning a series in Colorado last weekend. The Padres earned one win in the two opening home meetings against the Reds this week, entering Wednesday evening. The squad is a dominant 44-26 at home.

Jake Cronenworth is slumping, yielding a .543 OPS this month. The veteran second baseman has recorded 52 RBIs and a .754 OPS. Ryan O’Hearn has yet to register an RBI in September. The 32-year-old first baseman has clubbed 16 homers along with 54 RBIs on the year. Manny Machado has five RBIs this month. The veteran third baseman has 23 bombs with 84 RBIs on the year. Fernando Tatis Jr. has nine RBIs and a sharp .957 OPS against the Rockies this season. The star outfielder has smashed 20 big flies with 62 RBIs.

San Diego is scoring an average of 4.25 runs on the year, marking them 22nd. The pitching is a strength, reporting a 3.66 ERA, good for third.

Rockies vs. Padres Pick

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Spread Pick for Rockies vs. Padres

  • San Diego Padres -1.5 (5 units)

The Colorado Rockies have dropped five of their past six road games. The Rockies have been completely dominated by the rival San Diego Padres this season. The Padres have won seven of the nine meetings. These are huge games for the Padres, who are only two games out of first in the division and also hoping to hold onto the 2nd wildcard spot.

Furthermore, Rockies pitcher McCade Brown has been horrendous. The rookie just pitched against the Padres last week and gave up six in 1.2 innings in a 10-8 defeat. Brown has surrendered 13 runs in his three outings on the season, equating to a horrendous 12.54 ERA. Padres pitcher Randy Vasquez just pitched against Colorado last week and kept them to just two runs.  I recommend the run line, considering all of the Padres' wins against the Rockies this season have been by two or more runs.

Over/Under Pick for Rockies/Padres

  • Over (5 units)

I expect a barrage of runs. Colorado is scoring runs. They recorded 12 runs in three games against San Diego last week. They have averaged a decent 4.0 runs in their past 10 games. Vasquez has reported a weak 5.40 ERA in his career against Colorado.

In addition, San Diego has scored a stunning 70 runs in the nine meetings against the Rockies this season. Brown won’t pitch deep into the game. The rookie has yet to pitch into the fifth inning in his three outings. The Padres will have plenty of chances against a Rockies' bullpen that has a weak 5.26 ERA on the year, ranking 29th. The Rockies have conceded an average of 6.0 runs in their past ten games entering Wednesday evening.

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