Colorado Rockies vs Seattle Mariners Prediction and Picks - September 23, 2025

By: Dean Whitaker Published 09/23/2025, 07:00 AM ET
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Major League Baseball action on Tuesday evening, and we have a Colorado Rockies vs Seattle Mariners Prediction ready to rock and roll. The Rockies come in with the worst record in the league at 43-113. Seattle is red-hot as they have won 14 of their last 15 games and have grabbed hold of the American League West by three games over the Astros. Can the Mariners stay hot? Read on to see our Rockies vs Mariners prediction.

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Rockies Finish Weekend On A High Note

The Rockies closed out their home schedule with a rare bright spot, defeating the Angels 3–1 on Sunday behind six strong innings from Kyle Freeland and a two-RBI day from Blaine Crim. Crim homered in the fourth and added an RBI groundout in the eighth, while Victor Vodnik locked down his 10th save. The win improved Colorado to 43–113, narrowly avoiding a tie with the 1962 Mets for most losses in NL history. Despite the victory, the Rockies have dropped 7 of their last 8 and remain buried in last place in the NL West.

Now heading to Seattle, the Rockies begin their final road series of the season with little left to play for but pride and evaluation. Their road record sits at a brutal 18–57, and they’ve gone just 1–5 in interleague play this month. Still, the team has seen flashes from young contributors like Jordan Beck and Hunter Goodman, while Blaine Crim’s recent surge offers a glimmer of offensive hope. Defensively, Colorado has cleaned up some of its error issues, but the pitching staff continues to struggle with command and run prevention.

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McCade Brown will start Tuesday, entering with an 0–4 record and a 9.17 ERA across 23.1 innings. The rookie right-hander has shown strikeout potential (27 Ks) but has been plagued by walks and hard contact, allowing 28 hits and 15 walks in limited action. Brown will face a Mariners lineup that’s red-hot and aggressive early, so his ability to get ahead in counts and avoid the long ball will be critical. Colorado’s bullpen has been overworked, so length from Brown is a must if they hope to stay competitive.

Mariners Have Won 14 Of 15

The Mariners are surging at the perfect time, having completed a three-game sweep of the Astros with a 7–3 win on Sunday. J.P. Crawford launched a grand slam in the second inning, and Cal Raleigh added his MLB-leading 58th home run, breaking Ken Griffey Jr.’s franchise record. Logan Gilbert pitched six innings of one-run ball, and the bullpen closed it out cleanly. Seattle has now won 14 of its last 15 games, holds a three-game lead in the AL West, and sits two games ahead of Detroit for the second playoff seed.

Returning home for a three-game set against the league-worst Rockies, Seattle is in prime position to clinch its first division title since 2001. The Mariners are 48–27 at T-Mobile Park and have dominated interleague play, especially against bottom-tier opponents. Cal Raleigh’s power surge has been historic, while J.P. Crawford, Julio Rodríguez, and Josh Naylor continue to provide steady production. The bullpen, led by Andrés Muñoz and Matt Brash, has been nearly untouchable in high-leverage spots.

Bryce Miller will take the mound Tuesday, entering with a 9–7 record and a 4.12 ERA over 142.2 innings. The second-year righty has struck out 138 and walked just 32, relying on a high-spin fastball and tight slider to generate swings and misses. Miller has been especially sharp at home, and against a Rockies lineup that ranks near the bottom in OBP and slugging, he’ll look to pound the zone and work efficiently. With the division within reach, Miller’s start carries weight, and Seattle will be looking to strike early and often.

Colorado Rockies vs Seattle Mariners Pick

Rockies vs Mariners Moneyline Pick

  • Seattle -1.5 (5 Units)

The Mariners enter Tuesday’s matchup with every edge tilted in their favor—momentum, pitching, and opponent vulnerability. They’ve won 14 of their last 15 games and just swept the Astros, while Colorado limps in with a 43–113 record and a league-worst 6.02 team ERA. Bryce Miller has been solid at home and faces a Rockies lineup that ranks 29th in runs per game and 30th in fielding percentage. Seattle’s offense, led by Cal Raleigh’s record-breaking power and J.P. Crawford’s clutch hitting, has been punishing mistakes and jumping out early. Against McCade Brown, who owns a 9.17 ERA and a WHIP over 2.00, the Mariners should have no trouble building a multi-run cushion.

Backing Seattle on the runline (-1.5) is supported by both recent form and matchup data. The Mariners have covered the runline in five of their last six wins, and they’ve dominated Colorado in past meetings, including a 10–2 blowout last April. With the division title within reach and the Rockies offering little resistance, expect Seattle to stay aggressive, pile on early, and let their bullpen close the door. The runline play aligns with Seattle’s current urgency and Colorado’s inability to keep games close.

Rockies vs Mariners Over/Under Pick

  • Over (4 Units)

That read makes a lot of sense given the matchup dynamics. With the total currently set at 8.5, leaning toward the Over is supported by both team profiles and recent trends. The Rockies enter with a league-worst 6.02 ERA, and McCade Brown’s 9.17 mark over 23.1 innings suggests Seattle could do most of the heavy lifting themselves. Colorado’s bullpen has allowed 987 runs this season and ranks dead last in WHIP, FIP, and inherited runner scoring rate—a recipe for late-inning fireworks.

On the other side, the Mariners are averaging 4.74 runs per game and have hit 228 home runs this season. With Bryce Miller’s ERA sitting at 4.12 and Colorado’s lineup showing occasional pop from Hunter Goodman and Mickey Moniak, there’s potential for the Rockies to scratch across a few runs of their own. Seattle’s offense is red-hot, and if they jump out early, this game could easily push past nine runs before the seventh inning. The Over looks like a sharp angle, especially with playoff urgency driving aggressive plate approaches.

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