Detroit Tigers vs Cleveland Guardians Picks and Prediction for Tuesday, September 23, 2025
Use Code WWWC The Detroit Tigers (85-71, 1st AL Central) open a three-game series on the road Tuesday against American League Central division rival the Cleveland Guardians (84-72, 2nd). Detroit lost to the Atlanta Braves 6-2 on Sunday. The Tigers have been in a free fall the last two weeks, losing six straight and nine of the last 10. Detroit's lead in the AL Central has been reduced to one game over Cleveland. Cleveland lost to the Minnesota Twins 6-2 on Sunday, snapping a 10-game winning streak by the Guardians. Cleveland currently holds the third and final AL wild card. Both Detroit and Cleveland have 6 games remaining on the regular season schedule. Detroit will play without 6 pitchers as well as position players Franyerber Montilla, Matt Vierling, and Colt Keith. Cleveland will play without seven pitchers as well as position players Will Brennan, Lane Thomas, Tommy Hawke, and Justin Boyd. Make sure to read this in-depth Detroit Tigers vs Cleveland Guardians prediction. Chasing wins? Get the edge with our MLB picks for the Detroit Tigers at the Cleveland Guardians prediction right now.
Detroit is at risk of falling out of first place in the AL Central
The Detroit Tigers have held first place for nearly the entire season, but have lost six straight and 9 of the last 10. Detroit’s lead has been cut to just one game with six games remaining on the regular season schedule. Detroit's bats have gone quiet as the Tigers have been held to two runs or less in four of the last five games, and the Detroit pitching staff has given up four runs or more in five of the last six games.
Riley Greene has been the steady bat at the plate all season for Detroit, leading the Tigers in home runs (34), RBI (109), and hits (151). Spencer Torkelson is second in home runs with 31 and a distant second in RBI with 78. Detroit has four players with 62 or more RBI. The Tigers have hit 239 doubles, 36 triples, and 193 home runs for 468 extra-base hits in 156 games. Detroit is 12th in WHIP, 13th in batting average against, 16th in ERA, and 19th in Quality Starts. Tarik Skubal, who will start on the mound for Detroit on Tuesday, leads the Tigers in strikeouts with 233 and ERA for starts with 2.23. Casey Mize is the leader in wins with 14. Skubal is 13-5 with a 0.88 WHIP.
Cleveland is on the verge of clinching a postseason berth
The Cleveland Guardians have won 10 of the last 11 and 15 of the last 17. Cleveland was several games behind Detroit in the AL Central in early September, but has trimmed that lead to just one game. The Guardians are third in the AL wildcard chase, tied with Houston, but hold the tiebreaker between the two.
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Jose Ramirez has been Cleveland’s most productive hitter all season, leading the Guardians in home runs (30), RBI (81), on-base percentage (.359), and batting average (.282). Kyle Manzardo is second in both home runs with 26 and RBI with 68. The Guardians have hit 231 doubles, 17 triples, and 163 home runs for 411 extra-base hits in 156 games. The Tigers are 4th in ERA, 10th in batting average against, 15th in WHIP, and 16th in Quality Starts. Tanner Bibee leads the Guardians in wins with 11. Gavin Williams, who will start on the mound Tuesday for Cleveland, leads the Guardians in strikeouts with 161 and ERA for starters with 3.06. Williams is 11-5 with a 1.28 WHIP.
Detroit Tigers vs. Cleveland Guardians Pick
Spread Pick for Tigers vs. Guardians
- Cleveland Guardians (4 units)
Detroit has lost six straight and 9 of the last 10, while Cleveland has won nine of its last 10 and 15 of the last 17. Both starting pitchers have fared well in this matchup this season, but Cleveland’s starter has performed slightly better against the Tigers. Detroit starter Tarik Skubal is coming off a strong outing in which the left-hander gave up seven hits and one run in six innings when beating Cleveland 3-1 last Thursday for Detroit's only win in the last 10 games. In each of Skubal’s three starts against Cleveland this season, the Tigers won with Skubal allowing a total of 12 hits and one earned run in 21 innings, including a complete-game 5-0 victory on May 25. Cleveland starter Gavin Williams beat Detroit last Wednesday 4-0, allowing three hits and no runs in 5.0 innings. Cleveland is 1-1 in Williams’ two starts this season against Detroit. The right-hander allowed just 4 hits and no runs in 11 innings, but the bullpen gave up seven runs in the loss.
Over/Under Pick for Tigers vs. Guardians
- Under (5 units)
The two starting pitchers have excellent ERAs, with Detroit’s Skubal at 2.23 and Cleveland’s Gavin Williams at 3.06. The total has been under in 11 of Cleveland’s last 13 games, all of Cleveland’s last six games at home, and five of Cleveland’s last 7 head-to-head versus Detroit. Last week, when Skubal was on the mound, just four runs were scored, and when Williams was on the mound for Cleveland, just four runs were scored as well. The total finished under in two of three games last week between the two.
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