Detroit Tigers vs. Cleveland Guardians, Picks and Prediction, Thursday, September 25, 2025
Use Code WWWC Detroit (85-72) will be trying to retake sole possession of first place in the AL Central when they visit Progressive Field on Thursday night to face Cleveland (85-72) in the final game of their three-game series at 6:40 PM. ET.
Parker Messick, 3-0, 2.08 ERA, will get the start for the Tigers. The Guardians have not announced their starter for the game.
Cleveland is 6-4 in its last 10 games against Detroit.
Detroit Trying To End Slump
The Tigers had a big lead in the AL Central, but they struggled in recent weeks, losing 10 of their last 11 games. They are now tied with Cleveland for the AL Central lead, and will try to retake the division lead with a win on Thursday.
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Detroit averages 4.75 runs per game, which is 10th in the league. Their .247 batting average is 16th in the league. Their .316 on base percentage is 14th, while their .416 slugging percentage is 11th.
Riley Greene has been the big bat for the Tigers. He leads the team with a .261 batting average, 35 home runs, and 110 RBI.
Detroit is giving up 4.30 runs per game, which is 16th in the league. Opponents have a .242 batting average against the Tigers, which is 16th in the league. Their 3.98 ERA is 16th, while their 1.25 WHIP is 12th.
Cleveland Going For Series Win
The Guardians have been one of the hottest teams in the league over the past couple of weeks, and they’ve won their last five series. They will try to keep the momentum going and pick up the season series win when they play on Thursday.
Cleveland averages 3.96 runs per game, which is 27th in the league. Their .266 batting average is 29th in the league. Their .297 on base percentage is also 29th, while their .373 slugging percentage is 28th.
Jose Ramirez has been the big bat for Cleveland. He leads the team with a .282 batting average, 30 home runs, and 82 RBI.
Cleveland is giving up 3.99 runs per game, which is fifth in the league. Opponents have a .239 batting average, which is 10th in the league. Their 3.69 ERA is fourth, while their 1.27 WHIP is 15th.
In his last start, Messick gave up five hits and two runs in 5.1 innings, leading to a 6-2 win over Minnesota.
Tigers vs. Guardians Pick
Money Line Pick for Tigers vs. Guardians
- Cleveland Guardians ML (4 Units)
The Guardians have won 11 of their last 12 games, while the Tigers have lost 10 of their last 11 games. Cleveland has the edge here because they’re hitting the ball well and Detroit’s pitching staff has struggled in recent games, giving up 27 runs in their last four games, so expect the Guardians to play well offensively in this game.
Detroit won’t be as successful offensively because they didn’t hit the ball well in recent games, and they’re going up against Messick, who has done a good job on the mound, giving up four runs in his last three starts. He gave up one run in two home starts and will keep Detroit’s offense in check. Take Cleveland to cover the money line.
Over/Under Pick for Tigers vs. Guardians
- Under (4 Units)
The Tigers played under the total in their last two games, while the Guardians played under the total in their last four games. Detroit averages 4.75 runs per game and averaged three runs per game in their last three games. They’re batting .266 against left-handers, and they’re facing a starter who gave up one run in two home starts. The Guardians average 3.96 runs per game and five runs per game in their last three games. They’re batting .226 for the season, and they’re facing a pitching staff that gave up 4.75 runs per game in their last four games against Cleveland. Don’t expect these teams to score enough runs to push the score over the total. The Guardians and Tigers played under the total in two of their last three meetings.
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