Houston Astros vs Athletics Picks and Prediction for Sunday, September 27, 2026

The Houston Astros visit the Athletics on Sunday at Sutter Health Park, with the opening pitch scheduled for 3:05 PM ET and televised on MLB.TV. This is the final regular-season game for both teams. Houston is 79-81 and tied with Texas atop the AL West, keeping the Astros in the division race. Houston’s most recent result was a 6-5 loss to the Athletics on Friday. The Athletics are 64-96, fourth in the AL West, and have been eliminated from playoff contention. Oakland’s latest result was Friday’s 6-5 victory over Houston. Let’s get into the matchup and our free MLB picks. 

Houston Astros Trying to Finish With a Road Victory

Houston has split its last four games, scoring at least five runs in each contest. Yordan Alvarez has driven the lineup throughout the season, batting .315 with 41 home runs, 102 RBI, 176 hits, and a .433 on-base percentage. Isaac Paredes is hitting .260 with 24 home runs and 93 RBI, while Christian Walker has 28 homers and 85 RBI. Jeremy Pena has added a .271 average, 20 home runs, 51 RBI, and 12 stolen bases in 110 games.

The Astros are batting .240 with 712 runs, 220 home runs, a .313 on-base percentage and .414 slugging percentage. Houston ranks 21st in MLB batting and 24th in pitching with a 4.51 ERA, 1.35 WHIP, and .238 opponent average. The staff has recorded 1,396 strikeouts but issued 645 walks. Houston has also allowed 764 runs while scoring 712. The Astros have played solid defense, ranking tied for seventh in MLB with 70 errors and a .987 fielding percentage.

Injuries: Mike Burrows (out), Steven Okert (out), Daulton Varsho (out), Brice Matthews (out), Enyel De Los Santos (out).

Athletics Coming Off a One-Run Win

The Athletics have won three of their last four games, including Friday’s 6-5 victory over Houston. Shea Langeliers is batting .263 with a team-high 23 home runs and 58 RBI, while Zack Gelof has 22 homers, 54 RBI and 16 stolen bases. Henry Bolte is hitting .277 with 11 home runs, 38 RBI and 21 steals. Tyler Soderstrom has added 19 home runs, 56 RBI and a .338 on-base percentage across 109 games.

The Athletics are batting .246 with 697 runs, 194 home runs, a .318 on-base percentage and .404 slugging percentage. The offense ranks 13th in MLB, but the pitching staff ranks 29th with a 5.44 ERA, 1.50 WHIP, and .271 opponent average. Athletics pitchers have surrendered 915 runs, 239 home runs, and 1,490 hits. The defense ranks tied for 13th with 75 errors and a .986 fielding percentage. The Athletics are 32-47 at Sutter Health Park this season.

Injuries: Alika Williams (questionable), J.T. Ginn (out), Max Muncy (out), Brent Rooker (out), Nick Kurtz (out).

Pitching Matchup

Houston Astros - Undecided

Houston had not yet announced its starting pitcher at the time this preview was written.

Athletics - Brady Basso

Brady Basso is 1-3 with a 5.36 ERA and 1.60 WHIP across 42 innings. He has allowed 58 hits and four home runs while recording 30 strikeouts and nine walks.

Houston Astros vs Athletics Game Pick

• Houston Astros

Houston is the pick with the Astros holding major advantages in power and pitching numbers. Houston has hit 220 home runs compared with 194 for the Athletics, while the Astros have a 4.51 team ERA against Oakland’s 5.44 mark. Basso has allowed 58 hits across only 42 innings with a 1.60 WHIP, creating a favorable matchup for an Astros lineup led by Alvarez, Paredes and Walker. Houston also has a .238 opponent average compared with Oakland’s .271 mark this season.

Houston Astros vs Athletics Over/Under Pick

• Over

The play is over with the Athletics carrying a 5.44 team ERA and 1.50 WHIP into the regular-season finale. Oakland has allowed 915 runs and 239 home runs, while Basso has a 5.36 ERA and has surrendered 58 hits in 42 innings. Houston has scored at least five runs in each of its last four games, including seven and five in its two latest meetings with Oakland. The Athletics have also scored five or more runs in four straight games.