Houston Astros vs. Athletics Picks and Prediction for Wednesday, September 24, 2025
Use Code WWWC Houston Astros (84-72) vs. Athletics (73-83)
The 2025 Major League Baseball season is nearing its end, and the ultimate week is full of exciting matchups with playoff implications, including Wednesday’s clash at Sutter Health Park in Sacramento, California, so we have prepared the Astros vs. Athletics prediction to get you covered.
The Astros and the Athletics continue their three-game series in Sacramento, and Tuesday’s opener has been excluded from this preview. The Athletics have won six of their first 10 contests against the Astros in 2025, but Houston is in a must-win situation, with the postseason just around the corner.
Read more about this Astros vs. A’s prediction, and check out all our MLB picks for Wednesday’s slate. The first pitch at Sutter Health Park is set at 10:05 PM ET.
The Astros need a gem from Hunter Brown
The Houston Astros were tied with the Cleveland Guardians for the final wild-card spot in the American League on Tuesday morning. The Astros trailed the AL West-leading Seattle Mariners by three games, so winning the Athletics series looked like a must.
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Houston was swept by Seattle in a three-game series over the weekend. The Astros have gone 5-5 in their previous 10 games overall while scoring 44 runs on an underwhelming .229/.286/.352 slash line. Their bullpen has amassed a 3.16 ERA, 1.15 WHIP, and a .222 batting average against during that stretch.
Hunter Brown is projected to toe the slab at Sutter Health Park on Wednesday night. The 27-year-old right-hander has been nothing short of spectacular this season, going 12-8 with a 2.30 ERA and 1.01 WHIP in 30 starts (180.1 innings pitched). He’s allowed two or fewer runs in nine of his last 10 starts.
Brown is 4-2 with a strong 2.54 ERA and 1.11 WHIP in eight career starts against the Athletics. He’s met them twice this season and yielded just two earned runs on 10 hits and two walks through 11 innings of work. The current A’s are 22-for-76 with three doubles and two home runs against Brown.
The Athletics lean on their bullpen
The Athletics dropped a three-game road series against the Pittsburgh Pirates over the weekend. After taking the opener 4-3, the Athletics failed to score in the next two games, 2-0 and 11-0. The Athletics were fourth in the AL West on Tuesday morning, trailing the final wild card by 11 games.
The A’s have nothing to play for. Yet, they’ve won seven of their previous 10 games overall on the back of their bullpen. The Athletics’ relief pitching has been outstanding during that stretch, notching a 1.71 ERA, 1.10 WHIP, and a .203 batting average against.
J.T. Ginn is expected to take the mound on Wednesday night, and the 26-year-old righty carries a 4-6 record with a 4.57 ERA and 1.31 WHIP in 15 starts and seven relief appearances (86.2 IP) in 2025. He’s done a great job over his previous three showings, allowing just three earned runs on 12 hits and five walks through 15.1 frames of work.
Ginn has already met the Astros three times this season (one start). Across 10.2 innings, he’s yielded two earned runs on six hits and a walk. The last time they met, Ginn threw six scoreless frames in a 7-1 victory over the Astros in Houston on July 27.
Astros vs. Athletics Pick
Moneyline Pick for Astros vs. Athletics
- Houston Astros (4 units)
J.T. Ginn dominated the Astros in July. He’s pitched very well over his last three starts, but I have to back Hunter Brown to outpitch Ginn in this game. Ginn has been way more effective on the road this season. He’s 1-4 with a pedestrian 5.98 ERA and 1.56 WHIP at Sutter Health Park.
Brown is having a wonderful season. He’s been one of the best starting pitchers in baseball all season, and I expect him to torture the Athletics, who have recorded an underwhelming .650 OPS and 79 wRC+ against the righties in the past 10 days (216 plate appearances).
Houston has been slightly better against the righties during that span, tallying a .675 OPS and 89 wRC+ in 243 plate appearances. The Astros ‘pen has been solid in the past 10 days, posting a 3.43 ERA, 1.19 WHIP, and a .232 batting average against.
Over/Under Pick for Astros vs. Athletics
- Under (4 units)
I don’t trust J.T. Ginn despite his strong run of form in September. As I noted above, Ginn has struggled at home this season. However, should Hunter Brown and the bullpens continue to impress, we won’t see a lot of runs in this game.
I’ve mentioned how good Brown has been thus far. The Astros bullpen is full of dangerous arms, and the A’s bullpen has pitched lights out lately. The Athletics’ relievers boast the lowest ERA in baseball in September (2.58). Give me the under.
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