Houston Astros vs. Athletics Picks and Prediction, Thursday, September 25, 2025
Use Code WWWC The regular season is coming to a close and the playoff race is on fire on Thursday, Sept. 25. Read our Houston Astros vs Athletics prediction along with our other MLB Predictions to beat the sportsbooks! The Astros are stumbling as they have fallen out of the division race and are just outside of the wild card spot. The Athletics are out of playoff contention, but they have the Astros' number this season as they look to play spoiler. The Astros are set to start Framber Valdez, while JT Ginn gets the nod for the Athletics. The first pitch is set for 3:35 P.M. EST.
Houston stumbling towards the finish line
There are only a few days left in the regular season and Houston is hanging on for dear life to reach the playoffs. They are close to losing the division to Seattle, while they hope for a playoff berth through the wild card. Entering Wednesday, the Astros are one game back of Detroit for the final wild card spot in the American League. They are .500 when playing on the road. But, Houston has lost four straight entering Wednesday’s game. Before Wednesday’s game, the Astros had a 4-7 record against the Athletics.
Houston is set to start Framber Valdez is this key game against the Athletics. He is 12-11 with a 3.75 ERA in 30 starts. Valdez’s last start saw him throw 4.2 innings against the Mariners on Sept. 20. He allowed five runs and six hits in a 6-4 loss. The Astros have lost four straight games that Valdez has started. They have also lost nine of his last 10 starts. Houston is 7-8 when Valdez has started on the road. He has an ERA of 4.96 in 15 games when pitching on the road. Since the All-Star break, Valdez has a 5.63 ERA. He has also made four starts in September, holding a 8.27 ERA.
The Astros are hitting .250 this season, which ranks 12th in the league. They have scored the seventh fewest runs while they rank 10th in hits. Houston has hit the 17th most home runs while they have also struck out the seventh fewest times, too. They are hitting .252 this season on the road and .238 since the All-Star break. In September, the Astros are hitting .23,9 while they are also hitting .261 in 11 games against the Athletics.
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Athletics looking to play spoiler
The Athletics are in fourth place in the National League West. They have been eliminated from playoff contention for the past several weeks. They are below .500 when playing at home this season. Coming into Wednesday’s game, the Athletics have won eight of their last 11 games. The Athletics do hold a 7-4 record over Houston before their game on Wednesday.
On Thursday, the Athletics are set to start JT Ginn. The right-handed pitcher is 4-6 with a 4.57 ERA in 15 starts and seven relief appearances. Ginn’s last start saw him throw six innings against the Red Sox on Sept. 18. He allowed two runs and five hits in a 5-3 win. The Athletics have won three straight games when Ginn has played. They have also won five of his last six starts. He has an ERA of 5.98 when pitching at home. In three starts, he has a 1.76 ERA in September.
The Athletics are hitting .253 this season, which ranks fifth in the league. They have scored the 13th most runs while they also rank fifth in hits. The Athletics do have the second most doubles while ranking sixth in home runs. The Athletics are hitting .262 at home and .261 since the All-Star break. They have a .258 batting average in September and a .259 average in 11 games against Houston.
Astros vs Athletics Picks
Houston Astros vs Athletics Spread Pick
- Athletics -1.5 (5 units)
It doesn’t matter if the Athletics are eliminated from playoff contention; they are playing some solid ball at the moment. They have clinched the season series over the Astros as they continue to beat them at every corner of the schedule, too. They are starting JT Ginn, who has been great with his 1.76 ERA in September. The Athletics have won three straight games that he has started, while the Astros haven’t fared so well. They have been out of form over the past week, losing key games as they have dropped out of the playoff picture at the moment. They are also starting Framber Valdez, who hasn’t been good recently. He has a 5.63 ERA in the second half of the season. Houston has lost four straight games when he has started. They have also lost nine of his previous 10 games.
Take the Athletics to cover.Â
Astros vs Athletics Over/Under Pick
- Over 8.5 runs (5 units)
Framber Valdez has truly struggled to find consistent outs in the second half of the season and in September. He has a 5.63 ERA since the All-Star break. He also has an 8.27 ERA in four starts this month. The Athletics are hitting .259 off of Houston and .258 this month. They will get their runs while they are also starting JT Ginn, who has a 5.98 ERA at home. The Astros are hitting .261 against the Athletics this year, too.
Take the over on Thursday.Â
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