Houston Astros vs. Los Angeles Angels Picks and Prediction for Saturday, September 27, 2025
Use Code WWWC It’s the continuation of a three-game weekend series between AL West foes on the diamond out in the Golden State as the Houston Astros travel to face the Los Angeles Angels Saturday night and we have you covered with our Astros vs. Angels prediction. Houston salvaged the finale of a three-game set on the road with the Athletics as they prevailed 11-5 on Thursday. Los Angeles was dropped 9-4 in the rubber game of a three-game home set by the Royals Thursday night. Which team comes up with the victory in this contest ahead of Sunday’s series finale? This article was published before the conclusion of the opening game of the series at Angel Stadium on Friday night. Read more about this Astros vs. Angels prediction! Don’t go down on strikes! Increase your bankroll with our MLB Betting Picks!
Astros Fighting for Their Playoff Lives
Houston snapped a five-game skid as they took down the Athletics on the road in the finale of that set Thursday. The Astros entered Friday night 85-74 and stood second in the AL West, five games behind the Mariners for the top spot. They were one game behind the Tigers for the final wild card spot in the AL playoff picture. Against the Athletics on Thursday, Houston finished with 12 hits as Christian Walker (run, three RBI), Jose Altuve (two runs, two RBI) and Isaac Paredes (run, two RBI) each had two. Walker (his 24th) went deep in the contest for the Astros. Framber Valdez (13-11) earned the win as he threw seven innings, allowing one run on seven hits with two walks and 10 strikeouts, before departing.
The Astros have not officially named a starter here but the expectation is that AJ Blubaugh will make his 11th appearance, third start, of the season in this contest. He is 3-1 with a 1.93 ERA, a 0.821 WHIP, seven walks, and 33 strikeouts over 28 innings of work. Blubaugh didn’t factor in the decision in his last outing, which came in relief against the Mariners at home Sunday. He threw three scoreless innings, allowing no hits with no walks and one strikeout in a 7-3 Astros loss. In his last three outings, one start, Blubaugh is 1-0 with a 0.00 ERA, a 0.571 WHIP, one walk and eight strikeouts over seven innings of work. Blubaugh didn’t factor in the decision in his lone career appearance against the Angels, which came at home on August 31. He worked a 1-2-3 inning, striking out one, in a 3-0 Astros defeat. Blubaugh, in his 11th career major league appearance, third start, pitches at Angel Stadium of Anaheim for the first time here.
Los Angeles Trying to Play Spoiler
Los Angeles lost for the 11th time in 13 games as they were downed in the rubber game of their home set with the Royals Thursday night. The Angels entered Friday 71-88 and stood last in the AL West, 19 games behind the Astros for the top spot. They have been eliminated from contention for the final wild-card spot in the American League playoff chase. Against Kansas City, Los Angeles totaled seven hits as Jo Adell (run, RBI) was the lone player with two in the game. Mike Trout (his 23rd), Adell (his 37th) and Nolan Schanuel (his 12th) all went deep in a losing effort for the Angels. Mitch Farris (1-3) took the loss as he allowed four runs on five hits with two walks and five strikeouts over five innings of work.
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Caden Dana gets the ball for his seventh appearance, fifth start, of the season for the Angels in this contest. He is 0-3 with a 6.39 ERA, a 1.658 WHIP, 17 walks, and 28 strikeouts over 25.1 innings of work on the year. Dana took the loss in his last start, which came against the Rockies on Sunday on the road. He threw six innings, allowing two runs on three hits with three walks and five strikeouts in a 3-1 Angels loss. In his last three starts, Dana is 0-3 with a 7.53 ERA, a 1.88 WHIP, 11 walks, and 18 strikeouts over 14.1 innings of work. Dana took the loss in his lone career start against the Astros, which came September 15, 2024, at home. He threw 3.1 innings, allowing five runs (four earned) on five hits with two walks and three strikeouts in a 6-4 Angels loss. Dana is 1-2 with a 7.20 ERA, a 1.75 WHIP, 16 walks, and 22 strikeouts over 20 innings of work in five career appearances, three starts, at Angel Stadium of Anaheim.
Astros vs. Angels Pick
Moneyline Pick for Astros vs. Angels
- Astros (4 units)
The Angels have fallen apart over the last couple of weeks and wasted another season of Mike Trout as they are poised to finish in the AL West cellar. Eleven losses in 13 games entering Friday doesn’t instill confidence in their chances. Houston had dropped five straight before winning Thursday and find itself in danger of missing the postseason for the first time since 2016. Blubaugh has pitched well since coming up and has been a useful arm for the Astros. Dana has control issues and has been roughed up in his last three starts. Houston is in must-win mode and that helps motivate them to earn the victory in this contest.
Over/Under for Astros vs. Angels
- Over 8.5 (4 units)
Houston has seen the under post an 80-73-6 mark in their 159 games this season entering Friday. The Astros are tied for 21st in the majors in runs per game with 4.22 per contest, a number that edges up to 4.51 runs per game on the road. Their average total this season is 8.31 runs per game, though that climbs to 8.50 runs per game away from Daikin Park. Los Angeles has seen the over hit in 87 of their 159 games, with three pushes, this season entering Friday. The Angels are tied for 24th in the majors by averaging 4.19 runs per game, though they allow 5.17 runs per game, giving them an average of 9.36 runs per game. Los Angeles puts up 4.35 runs per game at home, while allowing 5.19 runs per game, giving them an average total of 9.54 runs per contest. With Dana struggling and the Astros desperate to put runs on the board, take the over here.
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