Houston Astros vs Seattle Mariners Picks and Prediction for Saturday, April 11, 2026
Use Code WWWC It’s a big divisional clash early in the season on Saturday, April 11. Read our Houston Astros vs Seattle Mariners prediction along with our other Free MLB Picks on the night. The Mariners have struggled to start this season, as they have lost five straight games coming into this weekend. The Astros have also lost five of their last six games, too. Houston is set to start Lance McCullers Jr., while Luis Castillo gets the nod for the Mariners. These two teams will meet with first pitch is set for 9:40 P.M. EST.
Astros trying to get over losing skid
Houston is 6-7 overall entering this weekend’s slate of games. The Astros are in third-place currently in the American League West division. Coming into this series, the Astros have lost four straight games. They have also lost five of their last six outings, too.
Lance McCullers Jr. gets the start for the Astros on Saturday. The right-handed pitcher is 1-0 with a 3.27 ERA in two starts this season. McCullers threw four innings and he allowed three runs and five hits against the Athletics on Sunday, April 5. In his first game of the season, McCullers tossed seven innings against the Red Sox. He allowed one run and four hits in an 8-1 win over Boston. McCullers has a career ERA of 4.30 when playing on the road. In 20 starts, McCullers has a 3.11 ERA against the Mariners in his career.
Houston is hitting .271 this season, which ranks second-best in the league. The Astros have scored the most runs in the league. They have hit the fourth-most home runs, while they have also struck out the third-fewest times. The Astros have hit .274 during road games this year, too.
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The Mariners struggles continue
Seattle enters this weekend with a 4-9 record, which is the worst mark in the American League West so far. The Mariners come into this series losing five straight games. They have also lost seven of their last eight games.
On Saturday, Luis Castillo gets the nod for the Mariners. The right-handed pitcher has made two starts this year with a 2.79 ERA. In his last start, Castillo tossed 3.2 innings against the Angels, where he allowed three runs and five hits. Castillo threw six innings against the Yankees in his first start of the year. He allowed zero runs and three runs, while striking out seven batters.
The Mariners have the worst batting average in the league with .184. Seattle has scored the fewest runs and the least amount of hits. The Mariners rank 18th in home runs, while they have striked out the sixth most times. Seattle is hitting .205 when playing at home this year.
Houston Astros vs Seattle Mariners Picks
Astros vs Mariners Spread Pick
- Take the Astros to cover (5 units)
In a low scoring game, it’s all about taking the opportunities presented. Houston has the bats to take these chances and score the necessary runs. Houston's offense ranks second-best in the league, while they have also scored the most runs. They will score enough runs on the road to seal the win, as Seattle’s offense is extremely poor. The Mariners have the worst batting average and the least amount of runs. This is the key difference and a reason for Houston to take the win.
Take Houston to cover.
Astros vs Mariners Over/Under Pick
Take the under (5 units)
The Mariners have the worst offense in the league so far this season. Seattle ranks last in batting average and runs scored so far. Seattle’s offense isn’t going to have any sort of success going against Lance McCullers Jr. and his career 3.11 ERA versus Seattle. The Astros will face Luis Castillo, who has an ERA less than 3.00 in his opening two starts. Take the under on Saturday.
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