Houston Astros vs Toronto Blue Jays Picks, Prediction, Odds, and Line Movement for Monday June 22 2026

By: Al MacMillan Published 06/22/2026, 01:29 PM ET
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Houston visits Toronto for a pitching duel featuring updated picks and top MLB player props for Monday night.

Best Available Odds

Best Moneyline Odds: Houston Astros (+108 at FanDuel) / Toronto Blue Jays (-125 at BetMGM)

Best Spread Odds: Houston Astros +1.5 (-200 at BetMGM) / Toronto Blue Jays -1.5 (+170 at Caesars)

Best Total Odds: Over 7.5 (+105 at Caesars) / Under 7.5 (+100 at BetMGM)

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Game Info

Date: June 22, 2026

Time: 7:07 PM EDT

Location: Rogers Centre, Toronto, ON

TV: Sportsnet, Space City Home Network, TVA Sports

Houston Astros vs Toronto Blue Jays Preview

The Houston Astros enter Monday at 37-42 after winning four of their last five games and securing three consecutive series victories. Houston closed its weekend series against Cleveland with a 2-1 win behind another home run from Yordan Alvarez and six strong innings from Kai-Wei Teng.

Houston remains below .500, but the club has moved back into the congested American League Wild Card race. The Astros have gone 17-11 since May 21 and have received considerably stronger pitching during that stretch.

The Astros have scored 356 runs, an average of approximately 4.51 per game. Their lineup is batting .243 with a .317 on-base percentage and .413 slugging percentage while producing 103 home runs.

Alvarez remains the centre of the offense. He enters batting .322 with a .428 on-base percentage, .640 slugging percentage, 25 home runs, and 56 RBIs. He leads the majors in slugging and ranks among the league leaders in nearly every major offensive category.

Alvarez hit his 25th home run Sunday, launching a first-inning shot against Cleveland before scoring Houston's second run later in the game. He has collected 14 hits, three home runs, and eight RBIs across his last 10 appearances.

Christian Walker adds 18 home runs and 52 RBIs, while Jeremy Peña, Isaac Paredes, Jose Altuve, Yainer Díaz, Cam Smith, and Joey Loperfido provide additional production throughout the order.

Houston's bullpen has become one of its greatest strengths. The Astros have ranked near the top of the American League in relief ERA, WHIP, and opponent batting average since the middle of May, helping them protect several narrow leads during their recent improvement.

The pitching staff remains depleted despite Hunter Brown's return. Ronel Blanco, Cristian Javier, Lance McCullers Jr., Hayden Wesneski, and Bennett Sousa remain unavailable, although several are progressing through rehabilitation assignments.

Houston is also without Carlos Correa for the season following ankle surgery. LaMonte Wade Jr., Nick Allen, and Braden Shewmake remain on the injured list, reducing the club's position-player depth.

The Toronto Blue Jays enter at 38-39 and one game below .500. Their scheduled Sunday game against the Chicago Cubs was postponed, giving Toronto an additional day of rest after an 8-6 comeback victory Saturday.

The Blue Jays have scored 316 runs, an average of approximately 4.10 per game. Toronto is batting .249 with a .311 on-base percentage and .391 slugging percentage while hitting 77 home runs.

Ernie Clement has been one of Toronto's most consistent hitters, batting .292 with 28 extra-base hits. Vladimir Guerrero Jr. enters batting .279 with a .365 on-base percentage, while Kazuma Okamoto leads the club with 16 home runs and 45 RBIs.

George Springer has begun producing more consistently after an injury-disrupted start to the season. He hit his 300th career home run during Toronto's June 16 victory in Boston and has shown improved power and plate discipline during his recent appearances.

Andrés Giménez, Davis Schneider, Alejandro Kirk, Daulton Varsho, Nathan Lukes, and Jesús Sánchez give the Blue Jays several secondary offensive options. Kirk and Varsho have recently returned from the injured list, strengthening a lineup that spent much of the season without multiple regulars.

Toronto remains without Addison Barger, Anthony Santander, Lenyn Sosa, and several pitchers. Max Scherzer is on the injured list with back spasms, while José Berríos underwent Tommy John surgery and will not return this season.

The Blue Jays bullpen has generally pitched well, but it was worked heavily during the series against Chicago. Toronto required extensive relief coverage Friday and Saturday after its starters completed only 5.2 combined innings.

Starting Pitchers and Pitching Matchup

The Astros will start right-hander Hunter Brown, who enters at 1-0 with a 1.10 ERA, 1.04 WHIP, and 24 strikeouts across 16.1 innings.

Brown made two starts at the beginning of the season before suffering a Grade 2 shoulder strain. He missed more than two months before being activated from the 60-day injured list on June 16.

His return against Detroit was encouraging. Brown allowed one run on three hits and three walks across 5.2 innings while striking out seven. His fastball reached the upper 90s, and he generated enough swing-and-miss production to resemble the pitcher who finished third in the 2025 American League Cy Young voting.

Brown has recorded at least seven strikeouts in all three of his starts this season. His 24 strikeouts across 16.1 innings translate to more than 13 strikeouts per nine innings.

Command was the primary concern in his return. Brown threw a lower percentage of pitches in the strike zone than usual and began fewer than half of the batters he faced with a first-pitch strike.

He nevertheless prevented Detroit from converting those command issues into damage. Brown allowed only three hits, avoided the home run, and escaped several counts by using his breaking pitches outside the zone.

Brown has also performed well against Toronto's current roster. Blue Jays hitters have combined for a .184 batting average and .294 weighted on-base average across 42 plate appearances against him.

Guerrero and Kirk are both hitless in six career at-bats against Brown. Those samples remain small, but his velocity and breaking-ball combination has created problems for Toronto's contact-oriented lineup.

The Blue Jays counter with right-hander Dylan Cease, who enters at 4-3 with a 2.71 ERA, 1.19 WHIP, and an American League-leading 110 strikeouts across 73 innings.

Cease has averaged approximately 13.6 strikeouts per nine innings. His 36.3% strikeout rate ranks among the highest in baseball, giving him the ability to escape innings without depending on Toronto's defense.

The right-hander returned from a left hamstring strain earlier in June. He delivered five scoreless innings against Boston in his latest start, allowing four hits and four walks while recording seven strikeouts.

Cease needed 108 pitches to complete those five innings. The strikeout production remained elite, but the four walks and extended at-bats prevented him from working deeper into the game.

His command remains the primary source of risk. Cease has issued 31 walks and averages approximately 3.8 per nine innings. Houston's lineup has enough patience to force him into deep counts and create opportunities even without generating a large number of hits.

Current Astros hitters have batted only .204 with a .272 weighted on-base average across 108 plate appearances against Cease. He has struck out 24.1% of those batters while limiting them to a .357 expected slugging percentage.

Alvarez presents the most dangerous matchup. He has punished right-handed pitching throughout the season and can convert one Cease mistake into immediate extra-base damage.

Game Thesis: This matchup does not contain the clear Toronto pitching advantage described by the moneyline. Cease has the stronger full-season workload, but Brown has allowed only two earned runs in three starts and looked effective in his return. Both pitchers can create strikeouts and prevent home runs, while Houston and Toronto possess capable bullpens. Houston offers greater moneyline value, but the most dependable angle is a low-scoring game.

⭐ Best Bet - Total Pick: Under 7.5 (+100)

The Under 7.5 is the strongest game wager. Brown and Cease have combined for 134 strikeouts across 89.1 innings and have allowed only seven home runs.

Brown's limited workload is a concern, but Houston should be comfortable allowing him to approach six innings after he completed 5.2 in his first start back. His velocity, strikeout production, and previous success against Toronto give him a realistic path to limiting the Blue Jays to two or three runs.

Cease has recorded at least seven strikeouts in five consecutive starts. His command can create baserunners, but Houston must still convert those opportunities against a pitcher holding opponents to a .192 batting average.

The current Astros roster has produced a .204 average against Cease, while Toronto's current hitters have managed a .184 average against Brown. Those matchup samples support the broader expectation of difficult contact on both sides.

Houston's bullpen has pitched at an elite level since the middle of May. Josh Hader, Bryan King, Steven Okert, and the rest of the relief staff protected a one-run lead Sunday and should be available after a manageable weekend workload.

Toronto's bullpen was worked more heavily in Chicago, but the postponed Sunday game provided a full day of recovery. Louis Varland and the Blue Jays' primary late-inning relievers should be available.

A final score around 4-2, 4-3, or 3-2 would remain below the listed total. The plus-money price offers strong value in a matchup featuring two of the league's highest-strikeout starters.

Moneyline Pick: Houston Astros (+108)

Houston is the preferred moneyline side because Brown reduces the starting-pitching gap implied by the market. He has allowed only two earned runs this season and recorded seven strikeouts in his first start after a long absence.

The Astros have also entered stronger overall form. Houston has won four of its last five games and three consecutive series while receiving excellent bullpen work.

Alvarez gives Houston the most dangerous hitter in the matchup. He leads the majors in slugging percentage and enters after homering Sunday, giving the Astros a realistic path to generating the decisive run even if Cease controls most of the lineup.

Toronto has home-field advantage and the more established 2026 starter, but Cease's command issues create opportunities for Houston to produce traffic. Four walks against Boston pushed him to 108 pitches through only five innings.

The Blue Jays also lack a major offensive advantage. Houston has scored 40 more runs despite playing only two additional games and possesses substantially more home-run power.

At plus money, the Astros provide better value than laying a favourite price with Toronto in a matchup that projects close to even.

Spread Pick: Houston Astros +1.5 (-200)

Houston +1.5 is the preferred run-line side because the matchup projects as a low-scoring, one-run game. The protection is valuable when both starting pitchers can limit opponents through five or six innings.

Brown's strikeout ability gives Houston a realistic opportunity to remain tied or within one run when the game reaches the bullpens. The Astros' recent relief performance also lowers the risk of Toronto pulling away late.

The Blue Jays have enough power through Okamoto, Guerrero, Springer, Giménez, and Varsho to win, but they have averaged only approximately 4.10 runs for the season. A large offensive performance is not the most likely outcome against Brown.

The primary drawback is the -200 price. The run line offers safety but limited value compared with the Houston moneyline and Under.

A projected score in the range of 4-3 or 3-2 makes Houston +1.5 the logical spread position, while the plus-money moneyline remains more attractive for bettors comfortable with the additional risk.

Top Player Prop Picks

Dylan Cease Over 6.5 Strikeouts (-124 at FanDuel) Cease leads the American League with 110 strikeouts and averages 8.5 per start. He has recorded at least seven strikeouts in five consecutive outings.

He reached seven against Boston despite completing only five innings and issuing four walks. His slider and high-velocity fastball allow him to generate strikeouts even when his overall command is inconsistent.

Houston's lineup has become more vulnerable to strikeouts during the last month. Walker, Paredes, Díaz, and several supporting hitters can produce power but also give Cease opportunities to reach two-strike counts.

Current Houston hitters have struck out in 24.1% of their plate appearances against Cease. Six innings at his season-long rate would project him above the listed number.

Hunter Brown Over 5.5 Strikeouts (-122 at FanDuel) Brown has cleared this number in all three of his starts, recording at least seven strikeouts each time. He enters with 24 strikeouts across only 16.1 innings.

Toronto is one of baseball's more difficult teams to strike out, making this a challenging matchup. The Blue Jays make consistent contact and rank near the top of the league in avoiding strikeouts.

Brown's individual stuff can overcome part of that matchup disadvantage. He struck out seven Tigers in his return despite working with inconsistent first-pitch command and making his first major-league appearance in more than two months.

His history against Toronto's current roster is also encouraging. Brown has struck out 26.2% of the Blue Jays hitters he has faced while limiting them to a .184 average.

Brown should receive enough workload to approach six innings if he remains effective. Six strikeouts is attainable at his current swing-and-miss rate.

Yordan Alvarez Over 0.5 Hits (-235 at BetMGM) Alvarez enters batting .322 with 91 hits, 25 home runs, and a major-league-leading .640 slugging percentage. He has recorded 14 hits across his last 10 games.

The matchup against Cease is difficult, but Alvarez remains the most dependable Houston hitter against elite right-handed pitching. His plate discipline prevents him from expanding the zone, while his power forces pitchers to work carefully throughout every plate appearance.

Alvarez homered Sunday and has reached base consistently for more than a month. He should receive at least three opportunities against Cease before facing Toronto's bullpen.

The price is expensive and offers less upside than the two strikeout props. However, Alvarez's contact quality, current form, and central lineup role support at least one hit.

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