Kansas City Royals vs Athletics Picks and Prediction for Friday, September 26, 2025

By: Kevin V. Published 09/26/2025, 10:26 AM ET
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The Kansas City Royals (79-79, 3rd AL Central) play the opening game of a three-game series on the road Friday against the Athletics (75-83, 4th AL West). Kansas City lost to the Los Angeles Angels 3-2 on Wednesday. The Royals have lost two of the last three and have been eliminated from postseason contention. The Athletics beat the Houston Astros 6-0 on Wednesday. The Aโ€™s have won four of the last six but have also been eliminated from postseason contention. Kansas City will play without 10 pitchers, as well as position players Connor Scott, Jack Pineda, and Kyle Isbel. The Athletics will play without 8 pitchers as well as position players Austin Wynns and Zack Gelof. Make sure to read this in-depth Kansas City Royals vs Athletics prediction. Hit a home run with our top MLB picks for the Kansas City Royals at Athletics Athletics prediction today!

Kansas City struggles at the plate but is better on the mound

The Kansas City Royals are 16th in batting average, 17th in slugging percentage, 22nd in on-base percentage, and 26th in runs scored. Vinnie Pasquantino leads Kansas City in home runs with 31 and RBI with 108. Bobby Witt Jr has been very productive at the plate with 44 doubles (1st), six triples (1st), 23 home runs (3rd), and 84 RBI (3rd). Kansas City has four players with 72 or more RBI. The Royals have hit 283 doubles, 22 triples, and 154 home runs for 459 extra-base hits in 158 games.

Kansas City has performed well on the mound. The Royals are 6th in ERA, 8th in Quality Starts, 11th in WHIP, and 13th in batting average against. Michael Wacha leads Kansas City in wins with nine and ERA, for starters, with 4.00. Seth Lugo is the leader in strikeouts with 125. On Friday, Kansas City will hand the ball to Noah Cameron. This season, the left-hander is 9-7 with a 2.90 ERA, 1.08 WHIP, and 108 strikeouts

The Athletics are strong at the plate but need help on the mountains

The Athletics are 5th in both batting average and slugging percentage, while 12th in runs scored, and 13th in on-base percentage. Nick Kurtz has been the power supply for the Athletics, leading the team in home runs with 33, and is third in RBI with 81, in just 113 games. Tyler Soderstrom is the leader in RBI with 93. The Athletics have three players with 30 or more home runs and three players with 81 or more RBI. The Aโ€™s have hit 287 doubles, 16 triples, and 216 home runs for 519 extra base hits in 158 games.

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On the mound, the Athletics have struggled, sitting 24th in batting average allowed, 25th in both WHIP and Quality Starts, while 27th in ERA. Jeffrey Springs leads the Aโ€™s in wins with 11, strikeouts with 138, and in ERA for starters of 4.11. On Friday, the Aโ€™s will hand the ball to Luis Morales. This season, the right-hander is 4-2 with a 3.07 ERA, 1.11 WHIP, and 38 strikeouts.

Kansas City Royals vs. Athletics Athletics Pick

Spread Pick for Kansas City Royals vs. Athletics

  • ย Athletics (4 units)

Kansas City starter Noah Cameron has had three consecutive strong outings, allowing 13 hits and five runs in 20.2 innings, resulting in Kansas City winning two of the three. Athleticsโ€™ starter Luis Morales has performed below average in each of his last three outings, allowing 15 hits and 10 runs in 15.2 innings, with the Athletics losing two of the three. Despite Kansas City having a slight advantage on the mound in this matchup, the Athletics have performed well of late, winning nine of their last 12 overall and each of their last six played at home. The Aโ€™s have won two straight over Houston, which is battling for a postseason berth. The Aโ€™s have produced well at the plate, with three players hitting 30 or more home runs and three players with 81 or more RBI. Kansas City has performed better on the mound than the Aโ€™s, but the Athletics sluggers will be the difference in this game.

Over/Under Pick for Kansas City Royals vs. Athletics

  • Underย  (4 units)

Kansas City has the sixth-best ERA in baseball at 3.75. The total has finished under in five of the Athletics' last six games, eight of the Athletics' last nine games against the team from the American League four of the Athletics' last five games played during September. Thirteen of Kansas City's last 20 games have finished under against teams from the American League.

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