Kansas City Royals vs Seattle Mariners Picks and Prediction for Wednesday, September 17, 2025

By: Kevin V. Published 09/17/2025, 04:50 AM ET
Kansas City Royals vs Seattle Mariners Picks and Prediction
Use Code WWWC

On Wednesday, the Seattle Mariners (82-68, 1st AL West) play the middle game of a three-game series on the road against the Kansas City Royals (75-75, 3rd AL Central). Seattle defeated the Los Angeles Angels 11-2 on Sunday for their 9th consecutive win and leads the American League West by a half-game over the Houston Astros. Kansas City snapped a three-game losing streak with a 10-3 victory over the Philadelphia Phillies on Sunday, but the Royals have lost six of the last eight. Kansas City trails the 3rd and final American League wild card spot by 6.5 games with just 12 games remaining on the regular season schedule. Seattle will play without three pitchers and second baseman Ryan Bliss. Kansas City will play without 13 pitchers and right fielder Connor Scott. Make sure to read this in-depth Seattle Mariners vs Kansas City Royals prediction. Step up to the plate! Check out our free MLB picks for the Seattle Mariners at Kansas City Royals prediction and swing for the fences.

This article was written before these two played on Tuesday.

Seattle is baseball's hottest club

The Seattle Mariners have won 9 straight and climbed into first place in the American League West. Seattle has performed above average at the plate as the Mariners are 10th in runs scored, 11th in slugging percentage, 12th in on-base percentage, and 20th in batting average. Seattle's most productive hitter has been Cal Raleigh, who leads baseball in home runs with 54 and has 114 RBIs to lead the club. Trade deadline acquisition Eugenio Suarez has been a disappointment thus far, as the slugger is batting just .170 since being acquired. Julio Rodriguez has been very productive with 30 doubles, 4 triples, 30 home runs, and 91 RBIs. Seattle has hit 215 doubles, 8 triples, and 216 home runs for 439 extra-base hits in 150 games.

Seattle is tough on the mound, as the Mariners are fifth in Quality Starts, 8th in WHIP, 14th in ERA, and 15th in batting average against. Bryan Woo leads Seattle in wins with 14, ERA for starters with 3.02, and strikeouts with 191. On Wednesday, Seattle will hand the ball to Bryce Miller. This season, the right-hander is 4-5 with a 5.59 ERA, 1.37 ERA, and 64 strikeouts.

Get Free $30 Credit for Premium Picks + Exclusive Discounts

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Winners and Whiners may use third-party services to process my data.

Kansas City is weak at the plate but solid on the mound

The Kansas City Royals have had a hard time producing runs this season. Kansas City is 18th in batting average, 21st in slugging percentage, 25th in on-base percentage, and a disappointing 28th in runs scored. Vinnie Pasquantino leads Kansas City in both home runs with 30 and RBI with 104. Bobby Witt Jr has been very productive at the plate, leading the Royals in doubles with 41 and triples with six, while third in both home runs with 22 and RBI with 79. Kansas City has hit 263 doubles, 21 triples, and 144 home runs for 428 extra base hits in 150 games.

Kansas City has been much better on the mound than at the plate this season as the Royals are fourth in ERA, 10th in Quality Starts, 13th in WHIP, and 14th in batting average against. Michael Wacha has 9 wins to lead Kansas City and has the best ERA for starters at 3.45, while Seth Lugo is the leader in strikeouts with 125. Cole Ragans will make his first appearance on the mound since June 5. The left-hander is 2-3 with a 5.15 ERA, 1.29 WHIP, and 76 strikeouts.

Kansas City Royals vs. Seattle Mariners Pick

Pick for Royals vs. Mariners

  • ย Seattle Mariners (4 units)

Seattle has far more incentive to win as the Mariners lead the American League West by just a half game over Houston, while Kansas City trails the final wild card spot by 6.5 games in the American League with only 12 games remaining, and will find it almost impossible to leapfrog so many teams. Seattle has won 9 straight games, and the Mariners have won 11 of the last 16 against Kansas City. The Royals have lost six of the last eight games overall. Seattle starter Bryce Miller has not performed well over the last five outings. The right-hander, across 28 innings, has allowed 23 hits and 18 runs, but Seattle has managed to win four of those five games. Kansas City starter Cole Ragans is coming off the injured list to start for the first time since June 5. The left-hander gave up 17 hits and 13 runs in 13 innings across three starts before being placed on the IL.

Over/Under Pick for Royals vs. Mariners

  • Over (5 units)

Seattle starting pitcher Bryce Miller has a very high ERA and has struggled in his last few appearances, while Kansas City starter Cole Ragans is coming off the 60-day IL and will likely go very few innings. The total has finished over in 9 of Seattleโ€™s last 13 games, in five of the Marinersโ€™ last six games on the road, and in each of Seattleโ€™s last nine games on the road against Kansas City. The total has also been over in 14 of the last 19 games overall between the team AL rivals.

Never Tried Winners and Whiners? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code DOLLAR
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
  • Check out more MLB predictions
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users โ€“ Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users โ€“ Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright ยฉ 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.