Los Angeles Angels vs. Seattle Mariners Picks and Prediction, Saturday, September 13, 2025 

By: Michael Briggs Published 09/13/2025, 04:16 AM ET
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On Saturday, the Los Angeles Angels will visit the Seattle Mariners at T-Mobile Park, and we have you ready to go with our Angels vs. Mariners prediction. First pitch is at 6:40 p.m. PT.

Seattle is a -220 moneyline favorite, and the game total is 7.5 runs scored.

This is the fourth series of the season between Anaheim and Seattle. The AL West ballclubs have split their last ten meetings, and the under was 5-4-1 in those ten games. If you want the Angels vs. Mariners prediction, read on and check out our MLB Predictions to beat the sportsbooks!

*Article published before the conclusion of Friday night's game.

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Los Angeles is coming off a series win

Los Angeles (69-77 SU, 78-68 RL, and 79-64-3 O/U) won two of three against Minnesota in its previous series. The Angels are 5-5 in their last ten games (the over/under was split 5-5).

The Halos will start southpaw Mitch Farris on Saturday against Seattle. In his last outing, the 24-year-old surrendered two runs and three hits, fanning four batters in six frames against the Athletics. The rookie has only made one other MLB appearance, a five-inning win at Kansas City on September 2. Farris was a 14th-round pick of Atlanta in the 2023 MLB draft out of Wingate.

Los Angeles lost 99 games last season, the most in franchise history. The club has made significant strides in 2025, flirting with .500 at various points in the season. They're also ten games over .500 against the run line. While it will take a serious push for LA to make the postseason, progress has been made.

Los Angeles Angels Baseball Injury Report: No new injuries for tomorrow's game against the Mariners.

Mariners are breathing down Houston's neck

Seattle (78-68 SU, 62-84 RL, and 79-61-6 O/U) swept St. Louis in its previous series. The Mariners are 6-4 in their last ten games (the over was 6-4).

Seattle will turn to righty Bryan Woo tomorrow against Los Angeles. In his last outing, the third-year MLB pro allowed two runs on three hits with nine strikeouts in six innings against the Cardinals. He is 13-7 with a 3.02 ERA and 0.95 WHIP in 28 starts (175.2 IP) this season, including 9-2 with a 2.40 ERA and 0.81 WHIP in 13 appearances at home (82.2 IP).

Seattle was among the most disappointing baseball teams last year, as it wasted a fantastic pitching rotation (2.85 ERA and a .205 OBA) with an inability to provide run support. The Mariners ranked 20th in runs scored in 2024, averaging 4.1 per game. Close losses were too common for M's fans, but they appear to have turned it around this year. Seattle has been more productive at the plate in 2025, ranking 11th in MLB in runs scored (4.66 per game), and has stayed competitive on the mound. Can they hunt down Houston and win the AL West?

Seattle Mariners Baseball Injury Report: No new injuries for Saturday's game against the Angels.

Angels vs. Mariners Pick

Run Line Pick for Angels vs. Mariners

  • Seattle Run Line -1.5 (5 Units)

The Mariners have never faced Farris, but they have been strong against southpaws this year, ranking sixth in wRC+. They have been a hot offensive team recently, too, ranking second in wOBA and wRC+ in the last week. I believe they'll score enough to win and cover the run line with Woo on the hill. The Mariners' starter is dominant at pitcher-friendly T-Mobile Park and has held current Halos hitters to a .151 BA and .203 wOBA in 55 plate appearances. He held Los Angeles to two runs in six innings earlier this season. Furthermore, Seattle's bullpen is reliable (8th in ERA), and the Angels' relief unit is not (28th in ERA).

Over/Under Pick for Angels vs. Mariners

  • Under 7.5 (4 Units)

Seattle's strength is against left-handers, but LA starter Farris has been excellent in his first two MLB outings. The 24-year-old may not dominate, but the Mariners' lack of previous experience against him could work in his favor. He should give the Angels decent length, too, which would take some pressure off their bullpen. With Woo starting for Seattle, that should result in a low-scoring game. He has a sub-2.5 ERA at home and in night games this season. This is a low total, but I recommend a wager on the under.

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