Los Angeles Dodgers vs. Arizona Diamondbacks Picks and Prediction, Wednesday, September 24, 2025
Use Code WWWC On Wednesday, the Los Angeles Dodgers will play the Arizona Diamondbacks at Chase Field, and we have you ready to go with our Dodgers vs. Diamondbacks prediction. First pitch from Phoenix is at 7:40 p.m. MT.
The Dodgers are -150 moneyline favorites, and the game total is 8.5 runs scored.
LA and Arizona have split their first ten matchups this season. The under was 7-2-1 in those ten games. If you want the Dodgers vs. Diamondbacks prediction, read on and check out our MLB Predictions to beat the sportsbooks!
*Article published before the conclusion of Tuesday's game.
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Los Angeles' Snell may be turning a corner
Los Angeles (88-68 SU, 66-88 RL, and 72-76-8 O/U) won three of four games against San Francisco in its previous series. The Dodgers are 6-4 in their last ten games (the over was 5-4-1).
LA will turn to left-hander Blake Snell tomorrow against Arizona. In his last start, the 32-year-old held Philadelphia to two hits and zero runs, fanning 12 Phillies in a seven-inning win. He is 5-4 with a 2.44 ERA and 1.28 WHIP in ten starts (55.1 IP) this season, including 0-3 with a 5.29 ERA and 1.47 WHIP in three road starts (17.0 IP).
The Dodgers are fresh off a World Series title with the biggest payroll in baseball, but with a 30-29 record in the second half, they are in a tight race to win the NL West. Los Angeles has all the talent in the world, but making it back to the top of the mountain will still be a challenge. Can they hold off San Diego in the division title race?
Los Angeles Dodgers Baseball Injury Report: No new injuries for Wednesday's game versus the D-Backs.
Diamondbacks must fight for every inch
Arizona (79-77 SU, 76-80 RL, and 75-72-9 O/U) won two of three against Philadelphia in its previous series. The Diamondbacks are 7-3 in their last ten games (the over/under was split 5-5).
Arizona will turn to righty Ryne Nelson tomorrow against Los Angeles. In his last start, the 27-year-old allowed two runs on five hits and two walks in five innings against the Phillies. He is 7-3 with a 3.34 ERA and 1.07 WHIP in 32 appearances (22 starts) this year, including 5-1 with a 2.58 ERA and 0.96 WHIP in 17 games at Chase Field (80.1 IP).
The Diamondbacks had a solid year in 2024, winning 89 games, but the ballclub couldn't build off of 2023's World Series appearance. With Los Angeles leading the pack and San Diego and San Francisco eager to stay competitive, the competition in the NL West has been as fierce as ever. Arizona has turned it on recently, sneaking back into the NL Wild Card picture. Can they chase down the final spot in the postseason?
Arizona Diamondbacks Injury Report: No injuries to report for Wednesday's game against the Dodgers.
Dodgers vs. Diamondbacks Pick
Moneyline Pick for Dodgers vs. Diamondbacks
- Arizona ML (5 Units)
The Diamondbacks are attractively priced on the moneyline at nearly +140 odds. I see value in their side, as both starting pitchers have momentum and both have fared well against Wednesday's opponent. Nelson has limited current Dodgers hitters to a .200 BA (88 combined plate appearances), allowing one run and three hits in two outings (7.0 IP) this season. Snell has held his last two opponents scoreless, but wasn't sharp in his previous start (five runs on nine hits and three walks vs. Pittsburgh on September 4). Arizona has fared well against southpaws this year (11th in both wRC+ and wOBA), and ranks 6th in wRC+ at Chase Field.
Every game is a must-win for the D-Backs, and considering that neither team has a significant starting pitching or bullpen edge, I recommend a wager on the home team's side tomorrow.
Over/Under Pick for Dodgers vs. Diamondbacks
- Over 8.5 (5 Units)
I'm not sold that Snell will have another dominant outing. He always offers up two or three free passes, and if he's not striking out ten-plus batters, he can find himself in too many jams. Arizona has struck out in just 19.1 percent of its ABs against left-handers, the third-lowest K% in MLB. If he's in more jams, he's unlikely to pitch past the fifth inning, too, which pressures an unreliable LA bullpen. As for Arizona, I believe Nelson can be trusted to limit the Dodgers' high-powered lineup, but I don't feel the same way about the home team's relief unit (28th in ERA).
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